n-3 fatty acids modulate adipose tissue inflammation and oxidative stress

2013 ◽  
Vol 16 (2) ◽  
pp. 124-132 ◽  
Author(s):  
Chaonan Fan ◽  
Hylde Zirpoli ◽  
Kemin Qi
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
And Oxidative Stress

Adipose Tissue Inflammation and Oxidative Stress: the Ameliorative Effects of Vitamin D

Inflammation ◽  
2017 ◽  
Vol 40 (5) ◽  
pp. 1688-1697 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mehran Mesgari-Abbasi ◽  
Ghazaleh Hajiluian ◽  
Ghazaleh Nameni ◽  
Parviz Shahabi
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
And Oxidative Stress

scholarly journals Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase

Toxins ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 502
Author(s):  
Shoma Tanaka ◽  
Hiroshi Watanabe ◽  
Takehiro Nakano ◽  
Tadashi Imafuku ◽  
Hiromasa Kato ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Nadph Oxidase ◽  
Organic Anion ◽  
Indoxyl Sulfate ◽  
Epididymal Adipose Tissue ◽  
Ros Production ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Anion Transporter

Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. IS induces monocyte chemoattractant protein-1 (MCP-1) expression and reactive oxygen species (ROS) production in the differentiated 3T3L-1 adipocyte. An organic anion transporter (OAT) inhibitor, an NADPH oxidase inhibitor or an antioxidant suppresses the IS-induced MCP-1 expression and ROS production, suggesting the OAT/NADPH oxidase/ROS pathway is involved in the action of IS. Co-culturing 3T3L-1 adipocytes and mouse macrophage cells showed incubating adipocytes with IS increased macrophage infiltration. An IS-overload in healthy mice increased IS levels, oxidative stress and MCP-1 expression in epididymal adipose tissue compared to unloaded mice. Using 5/6-nephrectomized mice, the administration of AST-120 suppressed oxidative stress and the expression of MCP-1, F4/80 and TNF-α in epididymal adipose tissue. These collective data suggest IS could be a therapeutic target for the CKD-related inflammatory response in adipose tissue, and that AST-120 could be useful for the treatment of IS-induced adipose tissue inflammation.

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance, and adipose tissue inflammation through PPARγ-dependent and PPARγ-independent actions

2015 ◽  
Vol 59 (5) ◽  
pp. 957-967 ◽  
Author(s):  
Thiago Belchior ◽  
Vivian A. Paschoal ◽  
Juliana Magdalon ◽  
Patricia Chimin ◽  
Talita M. Farias ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Glucose Intolerance ◽  
Adipose Tissue Inflammation ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Tissue Inflammation ◽  
Diet Induced Obesity

scholarly journals Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis

2017 ◽  
Vol 58 (9) ◽  
pp. 1797-1807 ◽  
Author(s):  
Patricia Chimin ◽  
Maynara L. Andrade ◽  
Thiago Belchior ◽  
Vivian A. Paschoal ◽  
Juliana Magdalon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Nlrp3 Inflammasome ◽  
De Novo ◽  
Inflammasome Activation ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Nlrp3 Inflammasome Activation ◽  
Ceramide Synthesis

scholarly journals Adipose Tissue Remodeling as Homeostatic Inflammation

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Michiko Itoh ◽  
Takayoshi Suganami ◽  
Rumi Hachiya ◽  
Yoshihiro Ogawa
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Inflammatory Responses ◽  
Saturated Fatty Acids ◽  
Tissue Remodeling ◽  
Low Grade ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Adipose Tissue Remodeling ◽  
Novel Therapeutic Strategies

Evidence has accumulated indicating that obesity is associated with a state of chronic, low-grade inflammation. Obese adipose tissue is characterized by dynamic changes in cellular composition and function, which may be referred to as “adipose tissue remodeling”. Among stromal cells in the adipose tissue, infiltrated macrophages play an important role in adipose tissue inflammation and systemic insulin resistance. We have demonstrated that a paracrine loop involving saturated fatty acids and tumor necrosis factor-α derived from adipocytes and macrophages, respectively, aggravates obesity-induced adipose tissue inflammation. Notably, saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 complex, thereby activating macrophages. Such a sustained interaction between endogenous ligands derived from parenchymal cells and pathogen sensors expressed in stromal immune cells should lead to chronic inflammatory responses ranging from the basal homeostatic state to diseased tissue remodeling, which may be referred to as “homeostatic inflammation”. We, therefore, postulate that adipose tissue remodeling may represent a prototypic example of homeostatic inflammation. Understanding the molecular mechanism underlying homeostatic inflammation may lead to the identification of novel therapeutic strategies to prevent or treat obesity-related complications.

scholarly journals Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

2019 ◽  
Vol 2019 ◽  
Author(s):  
Lucia Conti ◽  
Manuela Del Corn�� ◽  
Beatrice Scazzocchio ◽  
Rosaria Var�� ◽  
Massimo D��Archivio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Dietary Fatty Acids ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation

scholarly journals (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

2011 ◽  
Vol 2 (4) ◽  
pp. 304-316 ◽  
Author(s):  
Nishan S. Kalupahana ◽  
Kate J. Claycombe ◽  
Naima Moustaid-Moussa
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation
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