Therapeutic benefits of flavonoids against neuroinflammation: a systematic review

2022 ◽  
Author(s):  
Hamsalakshmi ◽  
Ann Maria Alex ◽  
Mahalakshmi Arehally Marappa ◽  
Suresh Joghee ◽  
Saravana Babu Chidambaram
Keyword(s):  
Systematic Review ◽  
Therapeutic Benefits

Effect of probiotics on the maintenance of intestinal homeostasis after chemotherapy: systematic review and meta-analysis of pre-clinical studies

2020 ◽  
Vol 11 (4) ◽  
pp. 305-318
Author(s):  
W.G. Lima ◽  
R.M. Pessoa ◽  
K.D. Vital ◽  
I.K.T.M. Takenaka ◽  
V.N. Cardoso ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Body Weight Loss ◽  
The Body ◽  
High Dose ◽  
Intestinal Homeostasis ◽  
Therapeutic Benefits ◽  
Potential Benefits ◽  
Gastrointestinal Mucositis ◽  
Pre Treatment

Gastrointestinal mucositis (GIM) is an inflammation caused by antitumor therapy, especially after chemotherapy and radiotherapy. Currently in the clinical practice, only palliative measures are taken to treat GIM, representing the main clinical limitation in the management of this condition. Several studies have highlighted the potential benefits of probiotics for the management of GIM, but the actual role of these microorganisms in the maintenance of intestinal homeostasis remains elusive. In this context, here we aimed to realise a systematic review with meta-analysis to evaluate the effect of probiotics on experimental GIM. The meta-analysis showed that probiotics significantly suppressed the body weight loss related to GIM in rodents (95% confidence interval (CI): -2.67 to -0.70; I2=98%, P<0.00). Subgroup analysis showed that pre-treatment (≥7 days before chemotherapy) (95% CI: -8.84 to -0.17; I2=98%, P<0.04) with a high dose of probiotics (≥ 109 cfu/day) (95% CI: -2.58 to -0.28; I2=98%, P<0.00) comprising two or more microorganism species (95% CI: -6.49 to -0.28; I2=96%, P=0.03) remedied GIM more effectively. It was also revealed that fungi (specifically Saccharomyces boullardii) are more effective in remedying GIM than bacteria (P=0.03 vs P<0.00), and the mouse models are more receptive than rats to the enteroprotective effects of probiotics (95% CI: -4.76, -0.69; I2=97%, P=0.01). Qualitative analyses highlighted that probiotics suppress GIM through several mechanisms; they reduce the intestinal permeability, suppress the pro-inflammatory cytokine production while stimulating production and secretion of anti-inflammatory cytokines, inhibit the signalling pathways coupled to inflammation and apoptosis, accelerate the proliferation of enterocytes, reduce the levels of reactive oxygen species, and help maintain the protective mucus layer. In conclusion, this review highlights the therapeutic benefits of probiotics in experimental GIM.

scholarly journals Exploring the therapeutic benefits of “Pranayama” (yogic breathing): A systematic review

2020 ◽  
Vol 13 (2) ◽  
pp. 99
Author(s):  
Ranil Jayawardena ◽  
Priyanga Ranasinghe ◽  
Himansa Ranawaka ◽  
Nishadi Gamage ◽  
Dilshani Dissanayake ◽  
...  
Keyword(s):  
Systematic Review ◽  
Therapeutic Benefits ◽  
Yogic Breathing

scholarly journals Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD

Diseases ◽  
2018 ◽  
Vol 6 (3) ◽  
pp. 80 ◽  
Author(s):  
Brandon Perumpail ◽  
Andrew Li ◽  
Umair Iqbal ◽  
Sandy Sallam ◽  
Neha Shah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fatty Liver Disease ◽  
Medical Literature ◽  
Therapeutic Option ◽  
Liver Function Tests ◽  
Safety And Efficacy ◽  
Nonalcoholic Fatty Liver ◽  
Therapeutic Benefits ◽  
Pubmed Database ◽  
Lobular Inflammation

Our aim is to review the efficacy of various herbs and supplements as a possible therapeutic option in the treatment and/or prevention of nonalcoholic fatty liver disease (NAFLD). We performed a systematic review of medical literature using the PubMed Database by searching the chemical names of many common herbs and supplements with “AND (NAFLD or NASH)”. Studies and medical literature that discussed the roles and usage of herbs and supplements in NAFLD and nonalcoholic steatohepatitis (NASH) from inception until 20 June 2018 were reviewed. Many studies have claimed that the use of various herbs and supplements may improve disease endpoints and outcomes related to NAFLD and/or NASH. Improvement in liver function tests were noted. Amelioration or reduction of lobular inflammation, hepatic steatosis, and fibrosis were also noted. However, well-designed studies demonstrating improved clinical outcomes are lacking. Furthermore, experts remain concerned about the lack of regulation of herbs/supplements and the need for further research on potential adverse effects and herb–drug interactions. In conclusion, preliminary data on several herbs have demonstrated promising antioxidant, anti-inflammatory, anti-apoptotic, and anti-adipogenic properties that may help curtail the progression of NAFLD/NASH. Clinical trials testing the safety and efficacy must be completed before widespread can be recommended.

The Effectiveness of Mirroring- and Rhythm-based interventions for children diagnosed with Autism Spectrum Disorder: A Systematic Review (Pre-print)

2020 ◽  
Author(s):  
Phoebe Morris ◽  
Ed Hope ◽  
Tom Foulsham ◽  
John Paul Mills
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Social Development ◽  
Communication Skills ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Beneficial Effects ◽  
Therapeutic Benefits ◽  
Autistic Population

Autism Spectrum Disorder (ASD) is characterised as a neurodevelopmental disorder that has continuing deficits in communication skills and social development. Utilising techniques known as mirroring and rhythm, Dance and Movement Therapy (DMT) has shown beneficial effects in the autistic population reducing these deficits. However, no review to date has investigated these individual techniques outside the practice of DMT. This systematic review of studies published between 1975 - 2020 aims to evaluate the effectiveness of both mirroring and rhythm as interventions that target communication skills and social development in children with ASD. Out of 1369 relevant articles, 11 of these met the inclusion criteria. All studies showed beneficial effects of mirroring and rhythm on communication skills and social development in children diagnosed with ASD. Therefore, incorporating these into new interventions and practices may offer substantial therapeutic benefits for children diagnosed with ASD.

scholarly journals Targeted Therapies for Skeletal Muscle Ion Channelopathies: Systematic Review and Steps Towards Precision Medicine

2020 ◽  
pp. 1-25
Author(s):  
Jean-François Desaphy ◽  
Concetta Altamura ◽  
Savine Vicart ◽  
Bertrand Fontaine
Keyword(s):  
Systematic Review ◽  
Skeletal Muscle ◽  
Sodium Channel ◽  
Precision Medicine ◽  
Human Studies ◽  
Channel Blockers ◽  
Preclinical Studies ◽  
Sodium Channel Blockers ◽  
Congenital Myopathies ◽  
Therapeutic Benefits

Background: Skeletal muscle ion channelopathies include non-dystrophic myotonias (NDM), periodic paralyses (PP), congenital myasthenic syndrome, and recently identified congenital myopathies. The treatment of these diseases is mainly symptomatic, aimed at reducing muscle excitability in NDM or modifying triggers of attacks in PP. Objective: This systematic review collected the evidences regarding effects of pharmacological treatment on muscle ion channelopathies, focusing on the possible link between treatments and genetic background. Methods: We searched databases for randomized clinical trials (RCT) and other human studies reporting pharmacological treatments. Preclinical studies were considered to gain further information regarding mutation-dependent drug effects. All steps were performed by two independent investigators, while two others critically reviewed the entire process. Results: For NMD, RCT showed therapeutic benefits of mexiletine and lamotrigine, while other human studies suggest some efficacy of various sodium channel blockers and of the carbonic anhydrase inhibitor (CAI) acetazolamide. Preclinical studies suggest that mutations may alter sensitivity of the channel to sodium channel blockers in vitro, which has been translated to humans in some cases. For hyperkalemic and hypokalemic PP, RCT showed efficacy of the CAI dichlorphenamide in preventing paralysis. However, hypokalemic PP patients carrying sodium channel mutations may have fewer benefits from DCP compared to those carrying calcium channel mutations. Few data are available for treatment of congenital myopathies. Conclusions: These studies provided limited information about the response to treatments of individual mutations or groups of mutations. A major effort is needed to perform human studies for designing a mutation-driven precision medicine in muscle ion channelopathies.

scholarly journals Comparing Mindful and Non-Mindful Exercises on Alleviating Anxiety Symptoms: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 17 (22) ◽  
pp. 8692
Author(s):  
Wendy Wing Yan So ◽  
Erin Yiqing Lu ◽  
Wai Ming Cheung ◽  
Hector Wing Hong Tsang
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Relative Effectiveness ◽  
Anxiety Symptoms ◽  
Clinical Population ◽  
Clinical Samples ◽  
Healthcare Intervention ◽  
Significant Group ◽  
The Public ◽  
Therapeutic Benefits

Background: In recent years, studies and reviews have reported the therapeutic benefits of both mindful and non-mindful exercises in reducing anxiety. However, there have not been any systematic reviews to compare their relative effectiveness for therapeutic application, especially among the non-clinical population. Thus, the aim of this review is to compare the effectiveness between mindful and non-mindful exercise on treating anxiety among non-clinical samples. Methods: Potential articles were retrieved from PubMed, Embase, Academic Search Premier, and PsycInfo. Randomized controlled trials, which involved both mindful and non-mindful exercises as intervention, and the use of anxiety outcome measures were included. Results: Twenty-four studies fulfilled the inclusion criteria and were included in our systematic review. In addition, 14 studies provided sufficient data to be included in the meta-analysis. For studies that reported significant group differences at post-assessment, results showed that mindful exercise was more beneficial in reducing anxiety than non-mindful exercise. The meta-analysis reported that yoga was more effective in reducing anxiety than non-mindful exercise. Conclusions: Compared to non-mindful exercise, yoga is shown to be more effective in alleviating anxiety symptoms. It is recommended that yoga could be used as a primary healthcare intervention to help the public reduce anxiety.

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