Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time

In this paper, I undertake a novel approach to uncover the forecasting interconnections in the international housing markets. Using a dynamic model averaging framework that allows both the coefficients and the entire forecasting model to dynamically change over time, I uncover the intertwined forecasting relationships in 23 leading international housing markets. The evidence suggests significant forecasting interconnections in these markets. However, no country holds a constant forecasting advantage, including the United States and the United Kingdom, although the U.S. housing market's predictive power has increased over time. Evidence also suggests that allowing the forecasting model to change is more important than allowing the coefficients to change over time.

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Detection of Acetaminophen and Its Glucuronide in Fingerprint by SALDI Mass Spectrometry Using Zeolite and Study of Time-Dependent Changes in Detected Ion Amount

Analytica ◽

10.3390/analytica2030008 ◽

2021 ◽

Vol 2 (3) ◽

pp. 66-75

Author(s):

Toshiki Horikoshi ◽

Chihiro Kitaoka ◽

Yosuke Fujii ◽

Takashi Asano ◽

Jiawei Xu ◽

...

Keyword(s):

Mass Spectrometry ◽

Glucuronic Acid ◽

Laser Desorption ◽

The Body ◽

Time Dependent ◽

Laser Desorption Ionization ◽

Fingerprint Analysis ◽

Desorption Ionization ◽

Acid Conjugate ◽

Over Time

The ingredients of an antipyretic (acetaminophen, AAP) and their metabolites excreted into fingerprint were detected by surface-assisted laser desorption ionization (SALDI) mass spectrometry using zeolite. In the fingerprint taken 4 h after AAP ingestion, not only AAP but also the glucuronic acid conjugate of AAP (GAAP), caffeine (Caf), ethenzamide (Eth), salicylamide (Sala; a metabolite of Eth), and urea were detected. Fingerprints were collected over time to determine how the amounts of AAP and its metabolite changed with time, and the time dependence of the peak intensities of protonated AAP and GAAP was measured. It was found that the increase of [GAAP+H]+ peak started later than that of [AAP+H]+ peak, reflecting the metabolism of AAP. Both AAP and GAAP reached maximum concentrations approximately 3 h after ingestion, and were excreted from the body with a half-life of approximately 3.3 h. In addition, fingerprint preservation was confirmed by optical microscopy, and fingerprint shape was retained even after laser irradiation of the fingerprint. Our method may be used in fingerprint analysis.

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Online Route Planning over Time-Dependent Road Networks

2021 IEEE 37th International Conference on Data Engineering (ICDE) ◽

10.1109/icde51399.2021.00035 ◽

2021 ◽

Author(s):

Di Chen ◽

Ye Yuan ◽

Wenjin Du ◽

Yurong Cheng ◽

Guoren Wang

Keyword(s):

Road Networks ◽

Route Planning ◽

Time Dependent ◽

Over Time

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The time-dependent angular analysis of Bd → KSℓℓ, a new benchmark for new physics

Journal of High Energy Physics ◽

10.1007/jhep02(2021)129 ◽

2021 ◽

Vol 2021 (2) ◽

Author(s):

Sébastien Descotes-Genon ◽

Martín Novoa-Brunet ◽

K. Keri Vos

Keyword(s):

Time Evolution ◽

Form Factors ◽

New Physics ◽

Time Dependent ◽

Angular Analysis ◽

Time Dependent Analysis ◽

Tensor Operators

Abstract We consider the time-dependent analysis of Bd→ KSℓℓ taking into account the time-evolution of the Bd meson and its mixing into $$ {\overline{B}}_d $$ B ¯ d . We discuss the angular conventions required to define the angular observables in a transparent way with respect to CP conjugation. The inclusion of time evolution allows us to identify six new observables, out of which three could be accessed from a time-dependent tagged analysis. We also show that these observables could be obtained by time-integrated measurements in a hadronic environment if flavour tagging is available. We provide simple and precise predictions for these observables in the SM and in NP models with real contributions to SM and chirally flipped operators, which are independent of form factors and charm-loop contributions. As such, these observables provide robust and powerful cross-checks of the New Physics scenarios currently favoured by global fits to b → sℓℓ data. In addition, we discuss the sensitivity of these observables with respect to NP scenarios involving scalar and tensor operators, or CP-violating phases. We illustrate how these new observables can provide a benchmark to discriminate among the various NP scenarios in b → sμμ. We discuss the extension of these results for Bs decays into f0, η or η′.

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General Anaesthesia Shifts the Murine Circadian Clock in a Time-Dependant Fashion

Clocks & Sleep ◽

10.3390/clockssleep3010006 ◽

2021 ◽

Vol 3 (1) ◽

pp. 87-97

Author(s):

Nicola M. Ludin ◽

Alma Orts-Sebastian ◽

James F. Cheeseman ◽

Janelle Chong ◽

Alan F. Merry ◽

...

Keyword(s):

Circadian Clock ◽

General Anaesthesia ◽

Wheel Running ◽

Phase Shifts ◽

Time Dependent ◽

Suprachiasmatic Nuclei ◽

Response Curves ◽

Inhalational Anaesthetic ◽

Locomotor Rhythms ◽

Time Dependent Analysis

Following general anaesthesia (GA), patients frequently experience sleep disruption and fatigue, which has been hypothesized to result at least in part by GA affecting the circadian clock. Here, we provide the first comprehensive time-dependent analysis of the effects of the commonly administered inhalational anaesthetic, isoflurane, on the murine circadian clock, by analysing its effects on (a) behavioural locomotor rhythms and (b) PER2::LUC expression in the suprachiasmatic nuclei (SCN) of the mouse brain. Behavioural phase shifts elicited by exposure of mice (n = 80) to six hours of GA (2% isoflurane) were determined by recording wheel-running rhythms in constant conditions (DD). Phase shifts in PER2::LUC expression were determined by recording bioluminescence in organotypic SCN slices (n = 38) prior to and following GA exposure (2% isoflurane). Full phase response curves for the effects of GA on behaviour and PER2::LUC rhythms were constructed, which show that the effects of GA are highly time-dependent. Shifts in SCN PER2 expression were much larger than those of behaviour (c. 0.7 h behaviour vs. 7.5 h PER2::LUC). We discuss the implications of this work for understanding how GA affects the clock, and how it may inform the development of chronotherapeutic strategies to reduce GA-induced phase-shifting in patients.

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