Crystal engineering and physicochemical properties of l-cysteine cadmium chloride (LCC) for frequency-doubling and optical limiting applications

2022 ◽  
Author(s):  
S. E. Allen Moses ◽  
J. Johnson ◽  
P. Nagaraju ◽  
Y. Raghu ◽  
R. Shanmugavalli ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Crystal Engineering ◽  
Cadmium Chloride ◽  
Frequency Doubling ◽  
Optical Limiting

Pharmaceutical Co-Crystals - Design, Development and Applications

2020 ◽  
Vol 10 (3) ◽  
pp. 169-184
Author(s):  
Rachna Anand ◽  
Arun Kumar ◽  
Arun Nanda
Keyword(s):  
Physicochemical Properties ◽  
Crystal Engineering ◽  
Pharmacological Action ◽  
Physicochemical Characteristics ◽  
Research Area ◽  
Dissolution Profile ◽  
Design Development ◽  
Drug Molecule ◽  
Wide Range ◽  
Major Factors

Background: Solubility and dissolution profile are the major factors which directly affect the biological activity of a drug and these factors are governed by the physicochemical properties of the drug. Crystal engineering is a newer and promising approach to improve physicochemical characteristics of a drug without any change in its pharmacological action through a selection of a wide range of easily available crystal formers. Objective: The goal of this review is to summarize the importance of crystal engineering in improving the physicochemical properties of a drug, methods of design, development, and applications of cocrystals along with future trends in research of pharmaceutical co-crystals. Co-crystallization can also be carried out for the molecules which lack ionizable functional groups, unlike salts which require ionizable groups. Conclusion: Co-crystals is an interesting and promising research area amongst pharmaceutical scientists to fine-tune the physicochemical properties of drug materials. Co-crystallization can be a tool to increase the lifecycle of an older drug molecule. Crystal engineering carries the potential of being an advantageous technique than any other approach used in the pharmaceutical industry. Crystal engineering offers a plethora of biopharmaceutical and physicochemical enhancements to a drug molecule without the need of any pharmacological change in the drug.

scholarly journals Cocrystallization of gliclazide with improved physicochemical properties

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Shivarani Eesam ◽  
Jaswanth S. Bhandaru ◽  
Raghuram Rao Akkinepally ◽  
Ravi Kumar Bobbala
Keyword(s):  
Physicochemical Properties ◽  
Crystal Engineering ◽  
Relative Bioavailability ◽  
Sem Analysis ◽  
Water Soluble ◽  
Spectral Studies ◽  
Pharmacokinetic Studies ◽  
Therapeutic Effects

Abstract Background Cocrystallization is one of the crystal engineering strategies used to alter the physicochemical properties of drugs that are poorly water-soluble. Gliclazide (GLZ), an antidiabetic drug, belongs to Biopharmaceutical Classification System class-II (low solubility and high permeability) and has low bioavailability, resulting in poor therapeutic effects in patients. Therefore, to impart better solubility and bioavailability of GLZ, the study was carried out by preparing GLZ cocrystals using liquid-assisted grinding method with three coformers [3,5-dinitrosalicylic acid (DNS), 2,6-pyridine dicarboxylic acid (PDA), and L-proline (LPN)], and these were characterized using Differential Scanning Colorimetry (DSC), Powder X-ray diffraction (PXRD), Fourier Transform Infra-red spectroscopy (FTIR), and Raman spectral studies. Further, Scanning electron microscopy (SEM) analysis, accelerated stability, solubility, in vitro dissolution studies, and in vivo pharmacokinetic studies were performed in male Wistar rats. Results DSC and PXRD analysis confirmed the formation of the GLZ cocrystals. Hydrogen bonding between pure GLZ and its coformers was demonstrated based on FTIR and Raman analysis. SEM data showed morphological images for GLZ cocrystals differed from those of pure GLZ. In comparison with pure GLZ, these GLZ cocrystals have greatly improved solubility, in vitro dissolution, and in vivo profiles. Among the three, GLZ–DNS cocrystals outperformed the pure drug in terms of solubility (6.3 times), degradation (1.5 times), and relative bioavailability (1.8 times). Conclusion Hence, cocrystallization of GLZ leads to improved physicochemical properties of poorly soluble drug gliclazide.

Crystal Engineering to Design of Solids: From Single to Multicomponent Organic Materials

2020 ◽  
Vol 17 (5) ◽  
pp. 518-538
Author(s):  
Andrea Mariela Araya-Sibaja ◽  
Cinira Fandaruff ◽  
Krissia Wilhelm ◽  
José Roberto Vega-Baudrit ◽  
Teodolito Guillén-Girón ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Physicochemical Properties ◽  
Dissolution Rate ◽  
Crystal Engineering ◽  
Organic Molecules ◽  
Organic Materials ◽  
Crystal Packing ◽  
Physical Stability ◽  
Bioactive Molecules ◽  
Crystal Lattices

Primarily composed of organic molecules, pharmaceutical materials, including drugs and excipients, frequently exhibit physicochemical properties that can affect the formulation, manufacturing and packing processes as well as product performance and safety. In recent years, researchers have intensively developed Crystal Engineering (CE) in an effort to reinvent bioactive molecules with well-known, approved pharmacological effects. In general, CE aims to improve the physicochemical properties without affecting their intrinsic characteristics or compromising their stability. CE involves the molecular recognition of non-covalent interactions, in which organic materials are responsible for the regular arrangement of molecules into crystal lattices. Modern CE, encompasses all manipulations that result in the alteration of crystal packing as well as methods that disrupt crystal lattices or reduce the size of crystals, or a combination of them. Nowadays, cocrystallisation has been the most explored strategy to improve solubility, dissolution rate and bioavailability of Active Pharmaceutical Ingredients (API). However, its combinatorial nature involving two or more small organic molecules, and the use of diverse crystallisation processes increase the possible outcomes. As a result, numerous organic materials can be obtained as well as several physicochemical and mechanical properties can be improved. Therefore, this review will focus on novel organic solids obtained when CE is applied including crystalline and amorphous, single and multicomponent as well as nanosized ones, that have contributed to improving not only solubility, dissolution rate, bioavailability permeability but also, chemical and physical stability and mechanical properties.

scholarly journals The Lisbon Supramolecular Green Story: Mechanochemistry towards New Forms of Pharmaceuticals

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2705
Author(s):  
João Luís Ferreira da Silva ◽  
M. Fátima Minas da Piedade ◽  
Vânia André ◽  
Sofia Domingos ◽  
Inês C. B. Martins ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Physicochemical Properties ◽  
Mechanochemical Synthesis ◽  
Crystal Engineering ◽  
Short Review ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Polymorphic Forms ◽  
Derivatives Of

This short review presents and highlights the work performed by the Lisbon Group on the mechanochemical synthesis of active pharmaceutical ingredients (APIs) multicomponent compounds. Here, we show some of our most relevant contributions on the synthesis of supramolecular derivatives of well-known commercial used drugs and the corresponding improvement on their physicochemical properties. The study reflects, not only our pursuit of using crystal engineering principles for the search of supramolecular entities, but also our aim to correlate them with the desired properties. The work also covers our results on polymorphic screening and describes our proposed alternatives to induce and maintain specific polymorphic forms, and our approach to avoid polymorphism using APIs as ionic liquids. We want to stress that all the work was performed using mechanochemistry, a green advantageous synthetic technique.

Structural diversity of hydrogen-bonded complexes comprising phenol-based and pyridine-based components: NLO properties and crystallographic and spectroscopic studies

CrystEngComm ◽  
2020 ◽  
Vol 22 (27) ◽  
pp. 4552-4565
Author(s):  
Iwona Bryndal ◽  
Marek Drozd ◽  
Tadeusz Lis ◽  
Jan K. Zaręba ◽  
Henryk Ratajczak
Keyword(s):  
Physicochemical Properties ◽  
Harmonic Generation ◽  
Crystal Engineering ◽  
Nonlinear Optical ◽  
Second Harmonic ◽  
Structural Diversity ◽  
Spectroscopic Studies ◽  
Nlo Properties ◽  
Optical Phenomena ◽  
Nonlinear Optical Phenomena

Synthesis of compounds with improved physicochemical properties, including nonlinear optical phenomena such as second harmonic generation, might be considered as one of the most challenging aspects of crystal engineering.

scholarly journals Cocrystals: A Review of Recent Trends in Pharmaceutical and Material Science Applications

2017 ◽  
Vol 14 (1) ◽  
pp. 09-18 ◽  
Author(s):  
Manjunath Javoor ◽  
Pradip Mondal ◽  
Deepak Chopra
Keyword(s):  
Charge Transfer ◽  
Physicochemical Properties ◽  
Supramolecular Chemistry ◽  
Crystal Engineering ◽  
Material Science ◽  
Molecular Crystals ◽  
Short Review ◽  
Pharmaceutical Cocrystals ◽  
Promising Area ◽  
Recent Trends

Over the last two decades, the design of multicomponent molecular crystals or cocrystals has grown out to be an interesting and promising area of research in pharmaceuticals and material science. Cocrystallization is at the interface of crystal engineering and supramolecular chemistry and allows us to vary the physicochemical properties of solids according to the need, through manipulation of various intermolecular interactions. In this short review, we focus on some recent reports on pharmaceutical cocrystals and emerging subclasses of cocrystals, namely: Charge transfer cocrystals, Energetic cocrystals, and Ternary cocrystals and discuss about their methods of characterization and applications of importance in the industry.

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