Anti-washout carboxymethyl chitosan modified tricalcium silicate bone cement: preparation, mechanical properties and in vitro bioactivity

Iron is one of the trace elements required by human body, and its deficiency can lead to abnormal bone metabolism. In this study, the effect of iron ions on the properties of tricalcium silicate bone cement (Fe/C3Ss) was investigated. It effectively solved the problems of high pH value and low biological activity of calcium silicate bone cement. The mechanical properties, in vitro mineralization ability and biocompatibility of the materials were systematically characterized. The results indicate that tricalcium silicate bone cement containing 5 mol% iron displayed good self-setting ability, mechanical properties and biodegradation performance in vitro. Compared with pure calcium silicate bone cement (C3Ss), Fe/C3Ss showed lower pH value (8.80) and higher porosity (45%), which was suitable for subsequent cell growth. Immersion test in vitro also confirmed its good ability to induce hydroxyapatite formation. Furthermore, cell culture experiments performed with Fe/C3Ss ion extracts clearly stated that the material had excellent cell proliferation abilities compared to C3Ss and low toxicity. The findings reveal that iron-doped tricalcium silicate bone cement is a promising bioactive material in bone repair applications.

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Study on physicochemical properties and in vitro bioactivity of tricalcium silicate–calcium carbonate composite bone cement

Journal of Materials Science Materials in Medicine ◽

10.1007/s10856-008-3423-4 ◽

2008 ◽

Vol 19 (8) ◽

pp. 2913-2918 ◽

Cited By ~ 33

Author(s):

Zhiguang Huan ◽

Jiang Chang

Keyword(s):

Calcium Carbonate ◽

Physicochemical Properties ◽

Bone Cement ◽

Tricalcium Silicate ◽

In Vitro Bioactivity ◽

Composite Bone

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Enhancing the mechanical properties and cytocompatibility of magnesium potassium phosphate cement by incorporating oxygen-carboxymethyl chitosan

Regenerative Biomaterials ◽

10.1093/rb/rbaa048 ◽

2020 ◽

Author(s):

Changtian Gong ◽

Shuo Fang ◽

Kezhou Xia ◽

Jingteng Chen ◽

Liangyu Guo ◽

...

Keyword(s):

Mechanical Properties ◽

Compressive Strength ◽

Physicochemical Properties ◽

Bone Cement ◽

Ph Value ◽

Setting Time ◽

Potassium Phosphate ◽

Carboxymethyl Chitosan ◽

Bioactive Substances ◽

Magnesium Potassium Phosphate Cement

Abstract Incorporating bioactive substances into synthetic bioceramic scaffolds is challenging. In this work, oxygen-carboxymethyl chitosan (O-CMC), a natural biopolymer that is nontoxic, biodegradable and biocompatible, was introduced into magnesium potassium phosphate cement (K-struvite) to enhance its mechanical properties and cytocompatibility. This study aimed to develop O-CMC/magnesium potassium phosphate composite bone cement (OMPC), thereby combining the optimum bioactivity of O-CMC with the extraordinary self-setting properties and mechanical intensity of the K-struvite. Our results indicated that O-CMC incorporation increased the compressive strength and setting time of K-struvite and decreased its porosity and pH value. Furthermore, OMPC scaffolds remarkably improved the proliferation, adhesion and osteogenesis related differentiation of MC3T3-E1 cells. Therefore, O-CMC introduced suitable physicochemical properties to K-struvite and enhanced its cytocompatibility for use in bone regeneration.

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Mixed phase bioceramics in the CaMgSi2O6 – MoO3 system: Mechanical properties and in-vitro bioactivity

Ceramics International ◽

10.1016/j.ceramint.2021.08.181 ◽

2021 ◽

Author(s):

Wen-Fan Chen ◽

Yu-Sheng Tseng ◽

Yu-Man Chang ◽

Ji Zhang ◽

Yun-Han Su ◽

...

Keyword(s):

Mechanical Properties ◽

Mixed Phase ◽

In Vitro Bioactivity

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Mechanical properties, corrosion behavior and in-vitro bioactivity of nanostructured Pd/PdO coating on Ti–6Al–7Nb implant

Materials & Design ◽

10.1016/j.matdes.2016.04.060 ◽

2016 ◽

Vol 103 ◽

pp. 10-24 ◽

Cited By ~ 24

Author(s):

A.R. Rafieerad ◽

A.R. Bushroa ◽

B. Nasiri-Tabrizi ◽

J. Vadivelu ◽

S. Baradaran ◽

...

Keyword(s):

Mechanical Properties ◽

Corrosion Behavior ◽

In Vitro Bioactivity

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The effect of calcinated hydroxyapatite and magnesium doped hydroxyapatite as fillers on the mechanical properties of a model BisGMA/TEGDMA dental composite initially and after aging

Metallurgical and Materials Engineering ◽

10.30544/403 ◽

2018 ◽

Vol 24 (4) ◽

Cited By ~ 2

Author(s):

Tamara Matic ◽

Maja Ležaja Zebić ◽

Ivana Cvijović-Alagić ◽

Vesna Miletić ◽

Rada Petrović ◽

...

Keyword(s):

Mechanical Properties ◽

Body Fluid ◽

Control Sample ◽

Dental Composite ◽

In Vitro Bioactivity ◽

Significant Difference ◽

Nanosized Hydroxyapatite ◽

Glass Fillers ◽

Mg Doped

The aim of this study was to investigate the possibility of modifying model BisGMA/TEGDMA dental composite by substituting 10 wt. % of conventional glass fillers with bioactive fillers based on calcinated nanosized hydroxyapatite (HAp) and Mg doped hydroxyapatite (Mg-HAp). HAp and Mg-HAp powders were synthesized hydrothermally. Mechanical properties: hardness by Vickers (HV) and flexural strength (Fs) were tested initially and after being stored for 28 days in simulated body fluid (SBF). The experimental composites with HAp and Mg-HAp particles showed no statistically significant difference in HV compared to the control (p>0.05) either initially or after storage. Although mean Fs values of modified composites tested initially were lower (62 MPa) than those of the control (72 MPa), after 28 days of storage in SBF Fs values were greater for modified composites (42 MPa control sample, 48 MPa HAp and Mg-HAp samples). In vitro bioactivity of BisGMA/TEGDMA composites with HAp and Mg-HAp particles after 28 days in SBF was not detected. Keywords: hydroxyapatite; magnesium; dental composite; mechanical properties;

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