Study of the Anticancer Activity of a New Nanosize Bismuth(V)-Based Coordination Complex Against Human Bone Tumor Cells

2021 ◽  
Author(s):  
Lei Pan ◽  
Yang Liu ◽  
Ming Bian ◽  
Dong Zhen ◽  
Zhi-Fang Zhang ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Human Bone ◽  
Coordination Complex

Anticancer Activity of Diosgenin and its Semi-synthetic Derivatives: Role in Autophagy Mediated Cell Death and Induction of Apoptosis

2021 ◽  
Vol 21 ◽  
Author(s):  
Nivedita Bhardwaj ◽  
Nancy Tripathi ◽  
Bharat Goel ◽  
Shreyans K. Jain
Keyword(s):  
Cell Death ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Tumor Cells ◽  
Cancer Progression ◽  
Rational Approach ◽  
Potential Candidate ◽  
Potential Implication ◽  
Apoptosis Protein ◽  
Synthetic Derivatives

: During cancer progression, the unrestricted proliferation of cells is supported by the impaired cell death response provoked by certain oncogenes. Both autophagy and apoptosis are the signaling pathways of cell death, which are targeted for cancer treatment. Defects in apoptosis result in reduced cell death and ultimately tumor progression. The tumor cells lacking apoptosis phenomena are killed by ROS- mediated autophagy. The autophagic programmed cell death requires apoptosis protein for inhibiting tumor growth; thus, the interconnection between these two pathways determines the fate of a cell. The cross-regulation of autophagy and apoptosis is an important aspect to modulate autophagy, apoptosis and to sensibilise apoptosis-resistant tumor cells under metabolic stress and might be a rational approach for drug designing strategy for the treatment of cancer. Numerous proteins involved in autophagy have been investigated as the druggable target for anticancer therapy. Several compounds of natural origin have been reported, to control autophagy activity through the PI3K/Akt/mTOR key pathway. Diosgenin, a steroidal sapogenin has emerged as a potential candidate for cancer treatment. It induces ROS-mediated autophagy, inhibits PI3K/Akt/mTOR pathway, and produces cytotoxicity selectively in cancer cells. This review aims to focus on optimal strategies using diosgenin to induce apoptosis by modulating the pathways involved in autophagy regulation and its potential implication in the treatment of various cancer. The discussion has been extended to the medicinal chemistry of semi-synthetic derivatives of diosgenin exhibiting anticancer activity.

Therapy and regeneration-combined bone cements for minimally invasive treatment of neoplastic bone defects

2021 ◽  
Author(s):  
Yu Qu ◽  
Hui Zhuang ◽  
Meng Zhang ◽  
Yufeng Wang ◽  
Dong Zhai ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Minimally Invasive ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Tumor Resection ◽  
Bone Defects ◽  
Bone Cements ◽  
Invasive Treatment ◽  
Calcium Phosphate Cements ◽  
Bone Tumor Resection

Although calcium phosphate cements (CPC) have been clinically used to repair bone defects caused by bone tumor resection, traditional CPC cannot kill the remaining tumor cells after surgery and prevent...

scholarly journals Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Targeted Delivery ◽  
Metastatic Tumor

Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin

2004 ◽  
Vol 113 (2) ◽  
pp. 179-188 ◽  
Author(s):  
Rochelle Bagatell ◽  
Jason Beliakoff ◽  
Cynthia L. David ◽  
Marilyn T. Marron ◽  
Luke Whitesell
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Solid Tumor ◽  
Hsp90 Inhibitors ◽  
Pediatric Solid Tumor ◽  
Apoptotic Proteins

Cryopreservation of Human Bone Marrow after Purging T-Cells or Tumor Cells

Cryobiology ◽  
1994 ◽  
Vol 31 (5) ◽  
pp. 478-482
Author(s):  
Zhong-Xing Zhang ◽  
Yuan-Ji Xu ◽  
Yuen Chen ◽  
Yan Li ◽  
Bei-Fen Shen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Tumor Cells ◽  
Human Bone ◽  
Human Bone Marrow

Induction of new-bone formation in the host bed by human bone-tumor transplants in athymic nude mice.

1979 ◽  
Vol 61 (8) ◽  
pp. 1207-1216 ◽  
Author(s):  
M R Urist ◽  
T T Grant ◽  
T S Lindholm ◽  
J M Mirra ◽  
H Hirano ◽  
...  
Keyword(s):  
Bone Formation ◽  
Nude Mice ◽  
Bone Tumor ◽  
Human Bone ◽  
New Bone Formation ◽  
Athymic Nude Mice

Two ho(III) metal-organic complexes constructed from two similar organic ligands: Anticancer activity against human spinal tumor cells

2019 ◽  
Vol 18 (2) ◽  
pp. 161-168
Author(s):  
Yi-Fu Sun ◽  
Li-Wei Shao ◽  
Qi Chen ◽  
Xu Gao ◽  
Fang Li ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Tumor Cells ◽  
Spinal Tumor ◽  
Organic Ligands ◽  
Organic Complexes ◽  
Metal Organic

Rolling of Human Bone-Metastatic Prostate Tumor Cells on Human Bone Marrow Endothelium under Shear Flow Is Mediated by E-Selectin

2004 ◽  
Vol 64 (15) ◽  
pp. 5261-5269 ◽  
Author(s):  
Charles J. Dimitroff ◽  
Mirna Lechpammer ◽  
Denise Long-Woodward ◽  
Jeffery L. Kutok
Keyword(s):  
Bone Marrow ◽  
Shear Flow ◽  
Tumor Cells ◽  
Prostate Tumor ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Prostate Tumor Cells

scholarly journals Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy

2020 ◽  
Vol 8 ◽  
Author(s):  
Hongshi Ma ◽  
Zhenjiang Ma ◽  
Qufei Chen ◽  
Wentao Li ◽  
Xiangfei Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Checkpoint Inhibitors ◽  
Tumor Therapy ◽  
Residual Tumor ◽  
Bone Defects ◽  
Silica Nanosphere ◽  
Large Bone ◽  
Large Bone Defects

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology via 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.

Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells

Bone ◽  
2013 ◽  
Vol 55 (1) ◽  
pp. 198-207 ◽  
Author(s):  
Isabella W.Y. Mak ◽  
Robert E. Turcotte ◽  
Michelle Ghert
Keyword(s):  
Parathyroid Hormone ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Migration And Invasion ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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