scholarly journals Determinants and Reference Ranges of Serum Immunoglobulins in Middle-Aged and Elderly Individuals: a Population-Based Study

2021 ◽  
Author(s):  
Samer Raza Khan ◽  
Layal Chaker ◽  
Mohammad Arfan Ikram ◽  
Robin Patrick Peeters ◽  
Petrus Martinus van Hagen ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Heavy Drinking ◽  
Serum Levels ◽  
Population Based ◽  
Community Dwelling ◽  
Specific Reference ◽  
Reference Ranges ◽  
Middle Aged ◽  
Higher Alcohol ◽  
Elderly Individuals

Abstract Purpose In clinical practice, currently one reference range for serum immunoglobulin (Ig) A, G, and M is applied to all adults, although various factors may influence Ig serum levels. Population-based data on determinants of IgA, IgG, and IgM and recommendations for subgroup specific reference ranges are lacking. We aimed to provide an overview of determinants of IgA, IgG, and IgM in community-dwelling middle-aged and elderly individuals and explore determinants that influence Ig reference ranges. Methods Within the Rotterdam Study, we performed linear regression analyses for the association of demographic, lifestyle, and cardiovascular factors with serum IgA, IgG, and IgM. We furthermore calculated Ig reference ranges (based on percentiles), both overall and within relevant subgroups. Results We included 8768 participants (median age 62 years). IgA and IgG increased non-linearly with higher age (P < .0001 for both). Women had lower IgA (beta: − 0.24; 95% confidence interval [95% CI]: − 0.29; − 0.20) and IgG (beta: − 0.33; 95% CI: − 0.44; − 0.23), but higher IgM levels (beta: 0.08; 95% CI: 0.04;0.13) than men. Former and particularly current smoking were associated with lower IgA and IgG (betas between − 0.07 and − 1.03). Higher alcohol consumption was associated with lower IgG (beta for heavy drinking: − 0.70; 95% CI: − 0.91; − 0.48). Corticosteroid use was associated with lower IgG (beta: − 1.12; 95% CI: − 1.58; − 0.66). Associations with cardiovascular factors were heterogeneous and differed between sexes. Conclusion Age, sex, smoking, alcohol consumption, corticosteroid use, and cardiovascular factors are determinants that should be considered when interpreting serum Ig levels in middle-aged and elderly individuals and may require adjusted reference ranges.

scholarly journals Development of reference ranges of handgrip strength among healthy adults 65+ in Northwest Russia: a prospective population-based cohort Crystal study

2017 ◽  
Vol 21 (4) ◽  
pp. 29-35 ◽  
Author(s):  
Anna V Turusheva ◽  
Elena V Frolova ◽  
Jean-Marie Degryse
Keyword(s):  
Cohort Study ◽  
Grip Strength ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Polynomial Regression ◽  
Population Based ◽  
Community Dwelling ◽  
Normative Values ◽  
Specific Reference ◽  
Reference Ranges

Objectives. This paper sought to provide normative values for grip strength among older adults 65+ across different age groups in northwest Russia. Methods. A population-based prospective cohort study of 611 community-dwelling individuals 65+. Grip strength was measured using the standard protocol applied in the Groningen Elderly Tests. The cut-off thresholds for grip strength were defined separately for men and women of different ages using a weighted polynomial regression. Results and conclusions. 1. This study presents age- and sex-specific reference values for grip strength in the 65+ Russian population derived from a prospective cohort study. 2. The grip strength values obtained in the current study were lower than those reported in other population-based studies in Europe and USA.

Sociodemographic Correlates of Health Beliefs among Black and White Community Dwelling Elderly Individuals

1994 ◽  
Vol 38 (4) ◽  
pp. 339-350 ◽  
Author(s):  
Anthony N. Galanos ◽  
Ronald P. Strauss ◽  
Carl F. Pieper
Keyword(s):  
Socioeconomic Status ◽  
Health Beliefs ◽  
Statistical Significance ◽  
Population Based ◽  
Community Dwelling ◽  
Bivariate Analysis ◽  
Elderly Individuals ◽  
Race And Gender ◽  
Black And White ◽  
And Gender

This study examined the hypothesis that sociodemographic characteristics such as age, education, race, and gender would be predictive of Multidimensional Health Locus of Control Subscale scores in a population-based sample of 342 community dwelling elderly individuals. Bivariate analysis revealed associations between black race, lower socioeconomic status, and lower education on the Chance and Powerful Others Subscales. While the multivariate analysis revealed no predictors for the Internal Subscale, a higher socioeconomic status, white race, and a higher level of education continued to predict low scores on the Chance Subscale when controlling for all other variables. Scores on the Powerful Others Subscale appeared to be a function of socioeconomic status and gender. Of note, the higher the education level for both men and women, the lower the scores on the Chance and Powerful Others Subscales. This sex by education interaction term reached statistical significance for the Chance Subscale. The results demonstrate the measurable influence of sociodemographic variables on the health beliefs of community dwelling elderly individuals.

Abstract P137: Association Of Equol Producing Capacity With Aortic Calcification In Middle-aged Japanese Men

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Xiao Zhang ◽  
Akira Fujiyoshi ◽  
Aya Kadota ◽  
Vasudha Ahuja ◽  
Abhishek Vishnu ◽  
...  
Keyword(s):  
Serum Levels ◽  
Population Based ◽  
Aortic Calcification ◽  
Inverse Association ◽  
Middle Aged ◽  
Cross Sectional ◽  
Japanese Men ◽  
The Us ◽  
Multivariable Analyses ◽  
20 Nm

Background: Soy isoflavones (ISFs) are regularly consumed in Japan and other Asian countries where some studies showed a significant inverse association of ISFs intake with incident coronary heart disease (CHD). However, a US randomized clinical trial did not find ISFs as anti-atherogenic. This discrepancy may be due to the higher capacity of people in Japan than in the US to produce equol, a metabolite of ISF by the gut microbiome. Equol may have greater anti-atherogenic properties than ISFs. It is unknown whether equol producers (EP), people who produce equol after consuming ISF, have lower aortic calcification (AC), a biomarker of atherosclerosis, as compared to non-EP. Aim: To determine the association between equol producing status and AC in Japanese men. Method: This cross-sectional, population-based study included 302 Japanese men aged 40-49, free of CHD. EP was defined as participants with serum levels of equol ≥20 nM. AC was measured in the entire aorta and quantified by the Agatston method. The presence of AC was defined as AC score ≥10. We analyzed the association between equol producing status and AC using the Tobit and the logistic regressions. Result: We observed 125 participants as EP. In multivariable analyses, EP had non-significantly lower AC score by 147 (95% confidence interval (CI): -386, 92) units and an odds ratio of 0.71 (95% CI: 0.40, 1.26) for the AC presence as compared to non-EP. As significant interaction of equol producing status with age was present, we stratified the analyses by the median age. In men aged 45-49 years, EP had non-significantly lower AC score by 246 units and a non-significant 0.62 times the odds of AC presence as compared to non-EP; the corresponding values in men aged 40-44 were 12 units and 0.91 times (Table). Such an association was not observed with serum ISFs (data not shown). Conclusion: Japanese middle-aged men who were EP had non-significantly lower AC than non-EP and such association was stronger in men aged 45-49 than 40-44 years. Further study with much larger sample size is warranted.

scholarly journals Age-Specific Reference Ranges of Prostate-Specific Antigen among Saudi Men as a Representation of the Arab Population

2019 ◽  
Vol 28 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Danny Munther Rabah ◽  
Karim Hamda Farhat ◽  
Mohamed Abdullah Al-Atawi ◽  
Mostafa Ahmed Arafa
Keyword(s):  
Prostate Specific Antigen ◽  
Sharp Increase ◽  
Specific Antigen ◽  
Serum Levels ◽  
Specific Reference ◽  
Reference Ranges ◽  
Arab Population ◽  
Blood Samples ◽  
Younger Men ◽  
Sugar Levels

Objective: To describe the reference ranges of serum prostate-specific antigen (PSA) in Saudi men. Materials/Subjects and Methods: Saudi males, aged 30 and above, were invited to participate in the study. Blood samples were taken from each subject to determine serum levels of PSA. Blood sugar levels, lipid profile, and anthropometric measurements were also obtained. Results: Our cohort consisted of 7,814 men; their mean PSA level was 1.24 ng/mL. The majority (90.5%) had PSA values between 0 and 2.5 ng/mL. The median PSA and the 95th percentile increased steadily with age. There was a sharp increase in the 95th percentile, from 3.8 ng/mL in men between 60 and 70 years old to 6.9 ng/mL in men over 71 years old. The 95th percentiles of PSA serum levels were lower in Saudi men than in the general population. Conclusions: PSA serum levels in Saudi men are lower than in other communities. Creating age-specific reference ranges could improve the sensitivity of the PSA tests by allowing the detection of treatable tumors in younger men if the threshold of 4.0 ng/mL is lowered. Furthermore, unnecessary biopsies among older men may be avoided if the threshold is increased.

Alcohol Consumption among Middle-Aged Women: A Population-Based Study of Swedish Women

2003 ◽  
Vol 10 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Jenny Cederfjäll ◽  
Jonas Lidfeldt ◽  
Christina Nerbrand ◽  
Göran Samsioe ◽  
Agneta Öjehagen
Keyword(s):  
Alcohol Consumption ◽  
Population Based ◽  
Middle Aged ◽  
Population Based Study
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