Indices of Efficiency of Multicomponent Separation in Cascades with Assigned External Concentrations of the Target Component

2020 ◽  
Vol 93 (3) ◽  
pp. 489-496
Author(s):  
V. A. Palkin ◽  
E. V. Maslyukov
Keyword(s):  
Target Component ◽  
Multicomponent Separation

Theory of Multicomponent Separation Potential

2015 ◽  
Vol 2 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Oleg Evgen’evich Aleksandrov ◽  
Vadim Maratovich Gadelshin
Keyword(s):  
Separation Potential ◽  
Multicomponent Separation

scholarly journals PAT for Continuous Chromatography Integrated into Continuous Manufacturing of Biologics towards Autonomous Operation

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 472
Author(s):  
Florian Lukas Vetter ◽  
Steffen Zobel-Roos ◽  
Jochen Strube
Keyword(s):  
Molecular Weight ◽  
Zero Point ◽  
Test System ◽  
Target Component ◽  
Array Detector ◽  
Continuous Manufacturing ◽  
Fluorescence Detector ◽  
Autonomous Operation ◽  
Side Component ◽  
Process Disturbances

This study proposes a reliable inline PAT concept for the simultaneous monitoring of different product components after chromatography. The feed for purification consisted of four main components, IgG monomer, dimer, and two lower molecular weight components of 4.4 kDa and 1 kDa molecular weight. The proposed measurement setup consists of a UV–VIS diode-array detector and a fluorescence detector. Applying this system, a R2 of 0.93 for the target component, a R2 of 0.67 for the dimer, a R2 of 0.91 for the first side component and a R2 of 0.93 for the second side component is achieved. Root mean square error for IgG monomer was 0.027 g/L, for dimer 0.0047 g/L, for side component 1 0.016 g/L and for the side component 2 0.014 g/L. The proposed measurement concept tracked component concentration reliably down to 0.05 g/L. Zero-point fluctuations were kept within a standard deviation of 0.018 g/L for samples with no IgG concentration but with side components present, allowing a reliable detection of the target component. The main reason inline concentration measurements have not been established yet, is the false-positive measurement of target components when side components are present. This problem was eliminated using the combination of fluorescence and UV–VIS data for the test system. The use of this measurement system is simulated for the test system, allowing an automatic fraction cut at 0.05 g/L. In this simulation a consistent yield of >99% was achieved. Process disturbances for processed feed volume, feed purity and feed IgG concentration can be compensated with this setup. Compared to a timed process control, yield can be increased by up to 12.5%, if unexpected process disturbances occur.

Solution space reduction of disassembly sequences generated automatically via computer aids

2014 ◽  
Vol 229 (16) ◽  
pp. 2977-2986 ◽  
Author(s):  
Louisa Issaoui ◽  
Nizar Aifaoui ◽  
Abdelmajid Benamara
Keyword(s):  
Solution Space ◽  
Target Component ◽  
Cad Model ◽  
Simulation Tool ◽  
Sequence Generation ◽  
Space Solution ◽  
Space Reduction ◽  
Automatic Sequence ◽  
Selective Disassembly

To develop a simulation tool for automatic disassembly in computer aid design (CAD) environment two difficulties are found: the huge space of generated sequences and their feasibility especially in combinatory generation. This article deals with automatic sequence generation for selective disassembly of mechanical product. Starting from a CAD model a new appropriate connection tree of a target component is constructed. This tree aims at reducing space solution by eliminatory rules. The generation of sequence is based on reading of connection tree branches and eliminatory tests of feasibility. The feasibility is checked by updating the disassembly mobility of each sequence’s element. A case study is presented to prove the effectiveness of the proposed approach.

Analysis for understanding and standardization of additive manufacturing processes

2021 ◽  
Author(s):  
Alexander Matschinski ◽  
Tim Osswald ◽  
Klaus Drechsler
Keyword(s):  
Additive Manufacturing ◽  
High Performance ◽  
Manufacturing Systems ◽  
Polymer Melt ◽  
Thermal Shrinkage ◽  
Target Component ◽  
Associated Functions ◽  
Cooling Mechanism ◽  
Characteristic Values ◽  
As Stress

The market segment of additive manufacturing is showing an annual growth of more than ten percent, with extrusion-based processes being the larger segment of the market. The scope of use is limited to secondary structures. Equipment manufacturers try to guarantee constant material characteristics by closed systems. The characteristic values are up to 50% below the ones from injection molding. The processing of high-performance polymers with reinforcing fibers is an additional challenge. Further development requires an opening of the material and manufacturing systems. The guidelines and standardization for this are still missing. For this reason, a functional analysis (FA) according to TRIZ ("theory of the resolution of invention-related tasks") is performed within this study. This identifies the undesired functions and quantifies their coupling with process components and parameters. In the FA, the manufactured part is the target component in order to address its quality. This way the FA identifies five undesirable functions in the process. These are: deform, cool, weaken, swell and shape. For hightemperature thermoplastics, thermal shrinkage is the primary cause of geometric tolerance. Therefore, the deformation is largely dependent on the cooling mechanism. For a detailed analysis, the polymer melt is further disassembled. The results are six sub-components. The weakening is mainly due to the physical phase of the voids, which exists during the entire processing. The breakdown comprises physical fields such as stress, temperature and flow. These determine the output properties as well as the bonding between the layers. The associated functions are the swelling and shaping. In order to generate broadly applicable standardizations, research questions for further investigation are derived from this study.

CONCEPTUAL MODEL OF IMPROVING THE EFFICIENCY OF PROJECT ACTIVITY AT THE LOCAL LEVEL

2018 ◽  
Author(s):  
Oleksandra Bazko ◽  
◽  
Nataliia Yushchenko ◽  
Keyword(s):  
Conceptual Model ◽  
Communicative Competence ◽  
Local Level ◽  
Organizational Factors ◽  
Target Component ◽  
Group Project ◽  
Project Activity ◽  
Proposed Model ◽  
Basic Approaches ◽  
Effective Use

The article proposes a conceptual model for improving the efficiency of project activities at the local level. The essence of project activity efficiency is determined and the basic approaches to the analysis of criteria and factors of project activity success in general are analyzed. The factors during the organization of group project activities are generalized and analyzed, including social-psychological, external-organizational factors and the level of readiness of territorial communities for project activities. It is determined that the level of readiness of territorial communities to carry out project activities is a set of motives, knowledge, skills, abilities, methods of project actions, personal qualities that ensure the successful interaction of its subjects. It is substantiated that the concept of the offered model consists in the most effective use of possibilities of group project activity for maintenance of qualitative formation of communicative competence of territorial communities, their personal and professional development. The key components of the proposed model are: conceptual-target, functional, structural, diagnostic. It is determined that the main purpose of the conceptual-target component is to form communicative competence, mastering the methods of solving problem-oriented tasks by means of project activities. The functional component of the model includes the identification of the entities on which the effectiveness of the project activity depends, and which carry out its evaluation. It was found that the structural component of the model contains the stages according to which project activities should be organized at the local level. The diagnostic component of the model contains criteria and indicators, levels, means of evaluating the effectiveness of project activities. Within this component, three levels of project activity efficiency (low, medium, high) are defined on the basis of taking into account the results achieved in the project activity process.

Simulation of Multicomponent Separation in Internally Heat Integrated Distillation Column using the Compact Heat Exchanger System

2008 ◽  
Vol 34 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Keigo Matsuda ◽  
Koichi Iwakabe ◽  
Masaru Nakaiwa ◽  
Hitoshi Kosuge ◽  
Sho Kataoka ◽  
...  
Keyword(s):  
Heat Exchanger ◽  
Distillation Column ◽  
Compact Heat Exchanger ◽  
Multicomponent Separation

scholarly journals WEAR RESISTANCE OF EPOXY COATINGS FILLED WITH SYNTHETIC WOLLASTONITE BASED ON RICE HUSK

2021 ◽  
Vol 6 (1) ◽  
pp. 66-73
Author(s):  
E. Gotlib ◽  
Phuong Ha ◽  
A. Hasanova ◽  
E. Galimov
Keyword(s):  
Wear Resistance ◽  
Silicon Dioxide ◽  
Calcium Silicate ◽  
Raw Materials ◽  
Synthesis Temperature ◽  
Chain Structure ◽  
Target Component ◽  
Epoxy Coatings ◽  
Synthetic Wollastonite ◽  
Natural And Synthetic

The extraction of natural wollastonite in the world is limited, so it is relevant to synthesize it on the basis of available calcium and silicon-containing raw materials, and it is promising to use rice husks as a source of silicon dioxide, as a waste of rice processing. Due to the needle shape of the particles, natural wollastonite increases the wear resistance of epoxy coatings, which arouses interest to study the influence of the phase composition and properties of synthetic wollastonite on this property. The calcium silicate synthesized by authors contains β-wollastonite, which is the target component. Its maximum content is achieved at a synthesis temperature not higher than 950 °C, approximately at the level of natural Mivall 10–97. Larnite is found as an impurity in the composition of synthetic wollastonite, it is an island silicate with a chain structure and therefore cannot provide such a modifying effect as fillers with anisodiametric particle shape. The nature of the particle size distribution curves of both natural and synthetic volastonite has two maxima, regardless of the filler synthesis temperature, with the exception of calcium silicate obtained at 900 °C, the particle distribution is narrower than in synthesized fillers, and they are smaller. The wear resistance of epoxy compositions, when filled with both natural and synthetic wollastonite, increases. The greatest increase in this indicator is achieved when using synthetic wollastonite, obtained at a ratio of calcium oxide and silicon dioxide 1: 1 and temperatures of 900-1000 °C. Thus, epoxy materials filled with both natural and synthetic wollastonium obtained at optimal ratios of the initial components and synthesis temperatures can be effectively and economically used as wear-resistant coatings.

scholarly journals Application of NEAT for the Simulation of Liquid-liquid Extraction Processes with Poorly Specified Feeds

2021 ◽  
Author(s):  
Fabian Jirasek ◽  
Jakob Burger ◽  
Hans Hasse
Keyword(s):  
Liquid Extraction ◽  
Target Component ◽  
Test Cases ◽  
Separation Processes ◽  
Nmr Spectrum ◽  
Liquid Liquid Extraction ◽  
Full Knowledge ◽  
Extraction Processes ◽  
Chemical Groups ◽  
Fluid Separation

The conceptual design of fluid separation processes is particularly challenging if the considered mixtures are poorly specified, since classical thermodynamic models cannot be applied when the composition is unknown. We have recently developed a method (NEAT) to predict activity coefficients in such mixtures. It combines the thermodynamic group contribution concept with the ability of NMR spectroscopy to quantify chemical groups. In the present work, we describe how NEAT can be applied to equilibrium stage simulations of liquid–liquid extraction processes with poorly specified feeds. Only a single 13C NMR spectrum of the feed is needed for predicting the distribution of a target component for different process parameters, such as temperature or extracting agent. The predictions from several test cases are compared to results that are obtained using the full knowledge on the composition of the feed and surprisingly good agreement is found.

Sign in / Sign up

Export Citation Format

Share Document