The 3′-untranslated region length and AU-rich RNA location modulate RNA–protein interaction and translational control of β2-adrenergic receptor mRNA

2011 ◽  
Vol 352 (1-2) ◽  
pp. 125-141 ◽  
Author(s):  
Kothandharaman Subramaniam ◽  
Karthikeyan Kandasamy ◽  
Kusumam Joseph ◽  
Eleanor K. Spicer ◽  
Baby G. Tholanikunnel
Keyword(s):  
Protein Interaction ◽  
Translational Control ◽  
Adrenergic Receptor ◽  
Untranslated Region ◽  
Receptor Mrna ◽  
Region Length ◽  
Β2 Adrenergic Receptor

scholarly journals Translational Control of β2-Adrenergic Receptor mRNA by T-cell-restricted Intracellular Antigen-related Protein

2004 ◽  
Vol 280 (3) ◽  
pp. 1931-1943 ◽  
Author(s):  
Karthikeyan Kandasamy ◽  
Kusumam Joseph ◽  
Kothandharaman Subramaniam ◽  
John R. Raymond ◽  
Baby G. Tholanikunnel
Keyword(s):  
T Cell ◽  
Translational Control ◽  
Adrenergic Receptor ◽  
Related Protein ◽  
Receptor Mrna ◽  
Β2 Adrenergic Receptor ◽  
Intracellular Antigen

scholarly journals The 3′-Untranslated Region of the β2-Adrenergic Receptor mRNA Regulates Receptor Synthesis

2004 ◽  
Vol 279 (26) ◽  
pp. 27108-27115 ◽  
Author(s):  
Kothandharaman Subramaniam ◽  
Kenneth Chen ◽  
Kusumam Joseph ◽  
John R. Raymond ◽  
Baby G. Tholanikunnel
Keyword(s):  
Adrenergic Receptor ◽  
Untranslated Region ◽  
Receptor Mrna ◽  
Β2 Adrenergic Receptor

Change in β1-adrenergic receptor protein concentration in adipose tissue correlates with diet-induced weight loss

2005 ◽  
Vol 108 (4) ◽  
pp. 323-329 ◽  
Author(s):  
Mads RASMUSSEN ◽  
Anita BELZA ◽  
Thomas ALMDAL ◽  
Søren TOUBRO ◽  
Palle BRATHOLM ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Adrenergic Receptor ◽  
Laser Scanning ◽  
Protein Concentration ◽  
Receptor Protein ◽  
Mrna Levels ◽  
Receptor Mrna ◽  
Β2 Adrenergic Receptor ◽  
Obese Subjects

The aim of the present study was to examine gene expression and protein concentrations of β1- and β2-adrenergic receptors in subcutaneous adipose tissue in obese subjects in response to weight loss. Eighteen obese subjects were studied during diet-induced weight loss. β-Adrenergic receptor mRNA levels were quantified by reverse transcription-PCR–HPLC. β-Adrenergic receptor protein concentrations were measured by Western blotting using fluorescence laser scanning for detection. Subjects lost 12.8±0.8 kg (mean±S.E.M.) during diet treatment. There was a 34% decrease in the β1-adrenergic receptor mRNA level (0.92±0.09 compared with 0.61±0.06 amol/μg of DNA; P<0.002). β2-Adrenergic receptor mRNA did not decrease significantly. β2-Adrenergic receptor protein concentration decreased 37% (25.5±7.1 compared with 16.0±5.6 arbitrary units/ng of DNA; P=0.008), whereas β1-adrenergic receptor protein concentration did not decrease significantly. The degree of weight loss was correlated with the concentration of β1-adrenergic receptor protein (r=0.65, P<0.003) and changes in receptor protein concentration (r=0.50, P=0.035) during the very-low-calorie diet. In conclusion, the present study demonstrates a relationship between β1-adrenergic receptor protein concentration in adipose tissue and the degree of weight loss. This relationship is not directly related to energy expenditure and deserves further investigation.

scholarly journals Distribution of β2-adrenergic receptor mRNA expression along the hamster nephron segments

FEBS Letters ◽  
1993 ◽  
Vol 318 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Shigeo Taniguchi ◽  
Tsuyoshi Watanabe ◽  
Akihide Nakao ◽  
George Seki ◽  
Shu Uwatoko ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Adrenergic Receptor ◽  
Nephron Segments ◽  
Receptor Mrna ◽  
Β2 Adrenergic Receptor
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