Effects of Trigonella foenum-graecum (L.) on retinal oxidative stress, and proinflammatory and angiogenic molecular biomarkers in streptozotocin-induced diabetic rats

2013 ◽  
Vol 388 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Suresh Kumar Gupta ◽  
Binit Kumar ◽  
Tapas Chandra Nag ◽  
B. P. Srinivasan ◽  
Sushma Srivastava ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Molecular Biomarkers ◽  
Trigonella Foenum Graecum ◽  
Trigonella Foenum Graecum L

Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats

2017 ◽  
Vol 42 (8) ◽  
pp. 816-828 ◽  
Author(s):  
Seetur R. Pradeep ◽  
Krishnapura Srinivasan
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Allium Cepa ◽  
Diabetic Rats ◽  
Dietary Interventions ◽  
Fenugreek Seeds ◽  
Soluble Fibre ◽  
Trigonella Foenum Graecum ◽  
Allium Cepa L ◽  
Trigonella Foenum Graecum L

Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p < 0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p < 0.05), especially from low-density lipoprotein−associated fraction by 43%, 35%, and 54%, respectively. Elevated concentrations of cholesterol and triglycerides in the liver and heart under diabetic conditions were significantly counteracted by these dietary interventions, with the additive combination resulting in greater effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when consumed together.

scholarly journals Beneficial effects of Fenugreek seeds (Trigonella foenum graecum L) added in the diet of diabetic rats

2012 ◽  
Vol 8 (2) ◽  
pp. 1555-1565 ◽  
Author(s):  
Najla Hfaiedh ◽  
Sabah Dhibi ◽  
Sakria Mbarki ◽  
Jean-Claude Murat ◽  
Abdel Fattah Elfeki
Keyword(s):  
Oxidative Stress ◽  
Alkaline Phosphatase ◽  
Thyroid Dysfunction ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Fenugreek Seeds ◽  
Beneficial Effects ◽  
Trigonella Foenum Graecum ◽  
Trigonella Foenum Graecum L ◽  
And Oxidative Stress

Protective effects of Fenugreek seeds (Trigonella foenum graecum L), added in the diet, upon oxidative stress and dysfunctions in kidney, thyroid and liver of alloxan-diabetic rats were investigated.In our study, the alloxan-induced diabetes triggered 1) increased levels of glucose, total cholesterol and triglycerides in blood, 2) increased activities of alkaline phosphatase and transaminases in blood, 3) increased levels of creatinine, urea and protein in blood, 4) a decreased level of TSH and an increased level of free thyroxin in plasma.In addition, an oxidative stress, evidenced by an increase of lipids peroxidation level and superoxide dismutase activity associated with a decrease of glutathione peroxidase and catalase activities in hepatic and renal tissues, was observed.When Fenugreek seeds powder (100g/kg) was added in the food for 30 days, all this parameters were significantly shifted to more normal values.In conclusion, fenugreek seeds powder displays beneficial effects upon hepatotoxicity, nephropathy, thyroid dysfunction and oxidative stress in alloxan-diabetic rats. This property could be attributed to the presence of antioxidant components, such as complex polysaccharides and phenolic acids, as confirmed by analyses. 

scholarly journals Effect of Trigonella foenum graecum L on the Activities of Antioxidant Enzyme and Their Expression in Tissues of Alloxan-Induced Diabetic Rats

2015 ◽  
Vol 20 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Sapneh Sharma ◽  
Vibhuti Mishra ◽  
Shiv Kumar Jayant ◽  
Nalini Srivastava
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Superoxide Dismutase ◽  
Diabetic Rats ◽  
Control Treatment ◽  
Trigonella Foenum Graecum ◽  
Production Of Hydrogen ◽  
Life Threatening ◽  
Trigonella Foenum Graecum L ◽  
The Brain

Diabetes is a life-threatening metabolic disorder. This study was undertaken to evaluate the antihyperglycemic and antioxidative potential of seed powder of Trigonella foenum-graecum L in alloxan (55 mg/kg) induced diabetic rats. The results obtained showed that extensive oxidative stress is generated in tissues of diabetic rats as evidenced by increased production of hydrogen peroxide, increased accumulation of malondialdehyde (MDA) and 4-hydroxynonanal (4HNE) and decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in tissues of diabetic rats. It was observed that the transcription of genes of SOD, GPx, and CAT was also significantly decreased when compared with control. Treatment of Trigonella for 15 days to diabetic rats showed hypoglycemic effect and improved the altered levels of H2O2, MDA, and 4HNE, the activities of SOD, GPx, and CAT as well as transcription of these genes in the liver and the brain of diabetic rats.

scholarly journals P0991EFFECTS OF TRIGONELLA FOENUM GRAECUM AND SODIUM ORTHOVANADATE ON ALTERED RENAL MEMBRANE FUNCTIONS IN ALLOXAN DIABETIC RATS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Pardeep Kumar ◽  
Najma Baquer
Keyword(s):  
Oxidative Stress ◽  
Blood Glucose ◽  
Glucose Transporter ◽  
Combined Therapy ◽  
Renin Angiotensin System ◽  
Polyol Pathway ◽  
Diabetic Rats ◽  
Sodium Orthovanadate ◽  
High Blood Glucose ◽  
Trigonella Foenum Graecum

Abstract Background and Aims The present study was carried out to observe, the antihyperglycemic and renoprotective effect of sodium orthovanadate (SOV) and Trigonella foenum graecum seed powder (TSP) administration on blood glucose, renal functions, expression of glucose transporter, DNA fragmentation, inflammatory cytokines and oxidative stress markers in kidney tissues and to see whether the treatment with SOV and TSP was capable of reversing the diabetic effects. Method Diabetes was induced by administration of alloxan monohydrate (15 mg/100 g body weight.) and rats were treated with 2 IU insulin, 0.6mg/ml SOV, 5% TSP in the diet and a combination of 0.2 mg/ml SOV and 5% TSP separately for three weeks. Renal damage was assessed by measuring proteinuria, enzymuria, expression of glucose transporters, renin-angiotensin system, and activities of polyol pathway enzymes. Results Diabetic rats showed hyperglycemia with almost four fold high blood glucose levels. Activity of Na+K+ATPase decreased in diabetic kidney. Diabetic rats exhibited an increased level of lipid peroxidation, intracellular Ca2+ levels, and decreased membrane fluidity. Combined therapy of lower dose of SOV with TSP significantly reduced metabolites of polyol pathway, oxidative stress, nitric oxide, and N-acetyl-β-d-glucosaminidase activity with glucose transporter in kidney of alloxan diabetic rats. Markers of podocyte damage in kidney (nephrin, podocin, and podocalyxin) and their urinary excretion were normalized along with downregulation of the expression of kidney injury molecule-1 by SOV and TSP treatment. TSP treatment alone is partially effective in restoring the above diabetes induced alterations. Dietary combined SOV and TSP effectively countered the diabetes-induced structural abnormalities of renal tissue. Conclusion Our results showed that lower doses of SOV (0.2mg/ml) could be used in combination with TSP to effectively in normalization of altered metabolic parameters and membrane linked enzymes without any harmful side effect and renoprotective actions.

scholarly journals Comparison the Effects of Trigonella foenum-graecum L. Seed and Cordia myxa Fruit Extracts on DiabetesInduced Memory Impairment in Rats

2017 ◽  
Vol 2 (4) ◽  
pp. 184-188 ◽  
Author(s):  
Fatemeh Yousef nasab ◽  
Mohammad Reza Hajinezhad ◽  
Hadi Hashemi ◽  
Abdolhossein Miri
Keyword(s):  
Lipid Peroxidation ◽  
Cognitive Dysfunction ◽  
Memory Task ◽  
Memory Loss ◽  
Diabetic Rats ◽  
Fenugreek Seeds ◽  
Trigonella Foenum Graecum ◽  
Significant Difference ◽  
Cordia Myxa ◽  
Trigonella Foenum Graecum L

Introduction: Trigonella foenum-graecum L. (Fenugreek) seeds and Cordia myxa fruits have been known as agents with anti-diabetes effects in Iranian traditional medicine. We compared the effects of aqueous extracts of these plants on diabetes-induced cognitive dysfunction. Methods: In our study, rats were equally allocated to 4 groups (n=12/group) as follows: control; diabetic; diabetic rats treated with T. foenum graecum seeds extract (TE) (870 mg/kg BW); and diabetic rats treated with C. myxa fruit extract (CE) (500 mg/kg BW) for 30 days. Diabetes was induced by alloxan (120 mg/kg BW, ip). Cognitive dysfunction was determined through memory task and passive avoidance learning (PAL). Results: Diabetes resulted in cognitive impairment in PAL and memory task. CE and TE significantly reduced serum blood sugar (P<0.05) and brain lipid peroxidation (P<0.001). Moreover, treatment with both extracts prohibited learning and memory deficits in diabetic groups in comparison to the non-treated group; however, there was no significant difference between the groups that were treated with TE or CE. Conclusion: Aqueous extract of fenugreek seeds and C. myxa are effective in preventing diabetesinduced lipid peroxidation and memory loss in animal models of diabetes.

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