scholarly journals Beneficial effects of Fenugreek seeds (Trigonella foenum graecum L) added in the diet of diabetic rats

2012 ◽  
Vol 8 (2) ◽  
pp. 1555-1565 ◽  
Author(s):  
Najla Hfaiedh ◽  
Sabah Dhibi ◽  
Sakria Mbarki ◽  
Jean-Claude Murat ◽  
Abdel Fattah Elfeki
Keyword(s):  
Oxidative Stress ◽  
Alkaline Phosphatase ◽  
Thyroid Dysfunction ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Fenugreek Seeds ◽  
Beneficial Effects ◽  
Trigonella Foenum Graecum ◽  
Trigonella Foenum Graecum L ◽  
And Oxidative Stress

Protective effects of Fenugreek seeds (Trigonella foenum graecum L), added in the diet, upon oxidative stress and dysfunctions in kidney, thyroid and liver of alloxan-diabetic rats were investigated.In our study, the alloxan-induced diabetes triggered 1) increased levels of glucose, total cholesterol and triglycerides in blood, 2) increased activities of alkaline phosphatase and transaminases in blood, 3) increased levels of creatinine, urea and protein in blood, 4) a decreased level of TSH and an increased level of free thyroxin in plasma.In addition, an oxidative stress, evidenced by an increase of lipids peroxidation level and superoxide dismutase activity associated with a decrease of glutathione peroxidase and catalase activities in hepatic and renal tissues, was observed.When Fenugreek seeds powder (100g/kg) was added in the food for 30 days, all this parameters were significantly shifted to more normal values.In conclusion, fenugreek seeds powder displays beneficial effects upon hepatotoxicity, nephropathy, thyroid dysfunction and oxidative stress in alloxan-diabetic rats. This property could be attributed to the presence of antioxidant components, such as complex polysaccharides and phenolic acids, as confirmed by analyses. 

Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats

2017 ◽  
Vol 42 (8) ◽  
pp. 816-828 ◽  
Author(s):  
Seetur R. Pradeep ◽  
Krishnapura Srinivasan
Keyword(s):  
Oxidative Stress ◽  
Beneficial Effect ◽  
Allium Cepa ◽  
Diabetic Rats ◽  
Dietary Interventions ◽  
Fenugreek Seeds ◽  
Soluble Fibre ◽  
Trigonella Foenum Graecum ◽  
Allium Cepa L ◽  
Trigonella Foenum Graecum L

Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats. These dietary interventions lowered oxidative stress, the combination producing a higher beneficial effect (p < 0.05), although not additive. Dietary fenugreek, onion, or fenugreek+onion countered hypercholesterolemia (p < 0.05), especially from low-density lipoprotein−associated fraction by 43%, 35%, and 54%, respectively. Elevated concentrations of cholesterol and triglycerides in the liver and heart under diabetic conditions were significantly counteracted by these dietary interventions, with the additive combination resulting in greater effect. These findings were also corroborated by restoration of histopathological abnormalities of heart and liver tissues along with lowered heart and liver weights. It is inferred that an alleviation of oxidative stress contributes further to the antidiabetic influence and this nutraceutical potential of fenugreek seeds and onion was higher when consumed together.

Protective effects of vitamins (C and E) and melatonin co-administration on hematological and hepatic functions and oxidative stress in alloxan-induced diabetic rats

2014 ◽  
Vol 70 (3) ◽  
pp. 713-723 ◽  
Author(s):  
Mohamed Salah Allagui ◽  
Anouer Feriani ◽  
Zouhour Bouoni ◽  
Hichem Alimi ◽  
Jean Claud Murat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Protective Effects ◽  
And Oxidative Stress

scholarly journals Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Maryem Ben Salem ◽  
Rihab Ben Abdallah Kolsi ◽  
Raouia Dhouibi ◽  
Kamilia Ksouda ◽  
Slim Charfi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Disorders ◽  
Diabetic Rats ◽  
Protective Effects ◽  
Cynara Scolymus ◽  
And Oxidative Stress

The Protective Effects of Vitamin E on Urinary Bladder Apoptosis and Oxidative Stress in Streptozotocin-induced Diabetic Rats

Urology ◽  
2010 ◽  
Vol 75 (4) ◽  
pp. 902-906 ◽  
Author(s):  
Mehmet C. Ustuner ◽  
Sahin Kabay ◽  
Hilmi Ozden ◽  
Gul Guven ◽  
Mehmet Yucel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Urinary Bladder ◽  
Diabetic Rats ◽  
Protective Effects ◽  
And Oxidative Stress

scholarly journals Effect of Trigonella foenum graecum L on the Activities of Antioxidant Enzyme and Their Expression in Tissues of Alloxan-Induced Diabetic Rats

2015 ◽  
Vol 20 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Sapneh Sharma ◽  
Vibhuti Mishra ◽  
Shiv Kumar Jayant ◽  
Nalini Srivastava
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Superoxide Dismutase ◽  
Diabetic Rats ◽  
Control Treatment ◽  
Trigonella Foenum Graecum ◽  
Production Of Hydrogen ◽  
Life Threatening ◽  
Trigonella Foenum Graecum L ◽  
The Brain

Diabetes is a life-threatening metabolic disorder. This study was undertaken to evaluate the antihyperglycemic and antioxidative potential of seed powder of Trigonella foenum-graecum L in alloxan (55 mg/kg) induced diabetic rats. The results obtained showed that extensive oxidative stress is generated in tissues of diabetic rats as evidenced by increased production of hydrogen peroxide, increased accumulation of malondialdehyde (MDA) and 4-hydroxynonanal (4HNE) and decreased activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) in tissues of diabetic rats. It was observed that the transcription of genes of SOD, GPx, and CAT was also significantly decreased when compared with control. Treatment of Trigonella for 15 days to diabetic rats showed hypoglycemic effect and improved the altered levels of H2O2, MDA, and 4HNE, the activities of SOD, GPx, and CAT as well as transcription of these genes in the liver and the brain of diabetic rats.

scholarly journals Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Anoja Priyadarshani Attanayake ◽  
Kamani Ayoma Perera Wijewardana Jayatilaka ◽  
Lakmini Kumari Boralugoda Mudduwa ◽  
Chitra Pathirana
Keyword(s):  
Oxidative Stress ◽  
Plant Extracts ◽  
Positive Control ◽  
Diabetic Rats ◽  
Histological Evaluation ◽  
Beneficial Effects ◽  
Risk Indices ◽  
Medicinal Plant Extracts ◽  
Alloxan Monohydrate ◽  
And Oxidative Stress

The objective of the present study was to investigate the effect of refluxed aqueous extracts of Gmelina arborea, Spondias pinnata, and Coccinia grandis on atherogenicity and oxidative stress in rats with chemically induced type 1 diabetes mellitus. Alloxan monohydrate (150 mg/kg, intraperitoneal) was used to induce diabetes to Wistar rats. Thereafter, diabetic rats (n=6 per group) were treated with the three selected plant extracts at their optimum effective therapeutic doses and glibenclamide (0.50 mg/kg, positive control) for 30 days. Administration of the three extracts in diabetic rats exhibited antihyperglycemic, antiatherogenic, and antioxidant effects in diabetic rats on the 30th day of the study. The atherogenic and coronary risk indices were also reduced in support of the antiatherogenic effects. The results of the study revealed that the bark extracts of G. arborea, S. pinnata, and leaf extract of C. grandis exerted beneficial effects against dyslipidemia, atherogenicity, and oxidative stress in alloxan induced diabetic rats. The selected plant extracts would be beneficial for the development of food supplements targeting main complications associated with diabetes.

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