N-Acetyl-tryptophan glucoside (NATG) protects J774A.1 murine macrophages against gamma radiation-induced cell death by modulating oxidative stress

2018 ◽  
Vol 447 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Poonam Malhotra ◽  
Ashutosh K. Gupta ◽  
Darshana Singh ◽  
Saurabh Mishra ◽  
Shravan K. Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Gamma Radiation ◽  
Murine Macrophages ◽  
Radiation Induced

Platelet-rich plasma ameliorates gamma radiation-induced nephrotoxicity via modulating oxidative stress and apoptosis

Life Sciences ◽  
2019 ◽  
Vol 219 ◽  
pp. 238-247 ◽  
Author(s):  
Ahmed F. Soliman ◽  
Mostafa Saif-Elnasr ◽  
Salma M. Abdel Fattah
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Platelet Rich Plasma ◽  
Radiation Induced

scholarly journals Modulatory effects of Chrysophyllum cainito L. extract on gamma radiation induced oxidative stress in rats

2019 ◽  
Vol 111 ◽  
pp. 613-623 ◽  
Author(s):  
D.F. Sayed ◽  
A.S. Nada ◽  
M. Abd El Hameed Mohamed ◽  
M.T. Ibrahim
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Radiation Induced ◽  
Chrysophyllum Cainito

Semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 protects against gamma radiation-induced oxidative stress

2014 ◽  
Vol 37 (2) ◽  
pp. 553-562 ◽  
Author(s):  
Saurabh Mishra ◽  
Poonam Malhotra ◽  
Ashutosh K. Gupta ◽  
Praveen K. Singh ◽  
Saleem Javed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Bacillus Sp ◽  
Radiation Induced

scholarly journals Protective effect of phloroglucinol against gamma radiation-induced oxidative stress in hair follicles

2016 ◽  
Vol 56 (1) ◽  
pp. 29-35
Author(s):  
Areum Kim ◽  
So Jin Bing ◽  
Jinhee Cho ◽  
KHINM Herath ◽  
You-Jin Jeon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gamma Radiation ◽  
Protective Effect ◽  
Hair Follicles ◽  
Radiation Induced

scholarly journals MicroRNA-223-3p Protect Against Radiation-Induced Cardiac Toxicity by Alleviating Myocardial Oxidative Stress and Programmed Cell Death via Targeting the AMPK Pathway

2022 ◽  
Vol 9 ◽  
Author(s):  
Dao-ming Zhang ◽  
Jun-jian Deng ◽  
Yao-gui Wu ◽  
Tian Tang ◽  
Lin Xiong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Myocardial Injury ◽  
Adenosine Monophosphate ◽  
Dependent Manner ◽  
Protective Effects ◽  
Compound C ◽  
Myocardial Oxidative Stress ◽  
Radiation Induced

Objectives: Radiotherapy improves the survival rate of cancer patients, yet it also involves some inevitable complications. Radiation-induced heart disease (RIHD) is one of the most serious complications, especially the radiotherapy of thoracic tumors, which is characterized by cardiac oxidative stress disorder and programmed cell death. At present, there is no effective treatment strategy for RIHD; in addition, it cannot be reversed when it progresses. This study aims to explore the role and potential mechanism of microRNA-223-3p (miR-223-3p) in RIHD.Methods: Mice were injected with miR-223-3p mimic, inhibitor, or their respective controls in the tail vein and received a single dose of 20 Gy whole-heart irradiation (WHI) for 16 weeks after 3 days to construct a RIHD mouse model. To inhibit adenosine monophosphate activated protein kinase (AMPK) or phosphodiesterase 4D (PDE4D), compound C (CompC) and AAV9-shPDE4D were used.Results: WHI treatment significantly inhibited the expression of miR-223-3p in the hearts; furthermore, the levels of miR-223-3p decreased in a radiation time-dependent manner. miR-223-3p mimic significantly relieved, while miR-223-3p inhibitor aggravated apoptosis, oxidative damage, and cardiac dysfunction in RIHD mice. In addition, we found that miR-223-3p mimic improves WHI-induced myocardial injury by activating AMPK and that the inhibition of AMPK by CompC completely blocks these protective effects of miR-223-3p mimic. Further studies found that miR-223-3p lowers the protein levels of PDE4D and inhibiting PDE4D by AAV9-shPDE4D blocks the WHI-induced myocardial injury mediated by miR-223-3p inhibitor.Conclusion: miR-223-3p ameliorates WHI-induced RIHD through anti-oxidant and anti-programmed cell death mechanisms via activating AMPK by PDE4D regulation. miR-223-3p mimic exhibits potential value in the treatment of RIHD.

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