The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes

2018 ◽  
Vol 449 (1-2) ◽  
pp. 251-255 ◽  
Author(s):  
Julia Matzenbacher dos Santos ◽  
Denise Silva de Oliveira ◽  
Marcos Lazaro Moreli ◽  
Sandra Aparecida Benite-Ribeiro
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Damage

Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

2016 ◽  
Vol 22 (18) ◽  
pp. 2650-2656 ◽  
Author(s):  
Noelia Diaz-Morales ◽  
Susana Rovira-Llopis ◽  
Irene Escribano-Lopez ◽  
Celia Bañuls ◽  
Sandra Lopez-Domenech ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Role of Oxidative Stress in Modulating Cutaneous Vasodilation and Sweating During Exercise in Type-2 Diabetes

2017 ◽  
Vol 49 (5S) ◽  
pp. 451
Author(s):  
Pegah Akbari ◽  
Naoto Fujii ◽  
Sheila Dervis ◽  
Robert D. Meade ◽  
Pierre Boulay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Cutaneous Vasodilation

Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease

2020 ◽  
Vol 160 ◽  
pp. 680-689 ◽  
Author(s):  
Sunil K. Saini ◽  
Mary M. McDermott ◽  
Anna Picca ◽  
Lingyu Li ◽  
Stephanie E. Wohlgemuth ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Mitochondrial Dna Damage ◽  
Walking Performance ◽  
Artery Disease

The role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species

2011 ◽  
Vol 43 (1) ◽  
pp. 25-29 ◽  
Author(s):  
R. A. P. Costa ◽  
C. D. Romagna ◽  
J. L. Pereira ◽  
N. C. Souza-Pinto
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mitochondrial Dna Damage

scholarly journals Sex Differences in Age-Associated Type 2 Diabetes in Rats—Role of Estrogens and Oxidative Stress

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ana Díaz ◽  
Raúl López-Grueso ◽  
Juan Gambini ◽  
Daniel Monleón ◽  
Cristina Mas-Bargues ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Replacement Therapy ◽  
Metabolic Profile ◽  
Estrogen Replacement Therapy ◽  
Diabetic Rats ◽  
Estrogen Replacement ◽  
Antioxidant Genes

Females live longer than males, and the estrogens are one of the reasons for this difference. We reported some years ago that estrogens are able to protect rats against oxidative stress, by inducing antioxidant genes. Type 2 diabetes is an age-associated disease in which oxidative stress is involved, and moreover, some studies show that the prevalence is higher in men than in women, and therefore there are sex-associated differences. Thus, the aim of this study was to evaluate the role of estrogens in protecting against oxidative stress in type 2 diabetic males and females. For this purpose, we used Goto-Kakizaki rats, which develop type 2 diabetes with age. We found that female diabetic rats showed lower glycaemia levels with age than did diabetic males and that estrogens enhanced insulin sensitivity in diabetic females. Moreover, glucose uptake, measured by positron emission tomography, was higher in the female brain, cerebellum, and heart than in those from male diabetic rats. There were also sex-associated differences in the plasma metabolic profile as determined by metabolomics. The metabolic profile was similar between estrogen-replaced and control diabetic rats and different from ovariectomized diabetic rats. Oxidative stress is involved in these differences. We showed that hepatic mitochondria from females produced less hydrogen peroxide levels and exhibited lower xanthine oxidase activity. We also found that hepatic mitochondrial glutathione oxidation and lipid oxidation levels were lower in diabetic females when compared with diabetic males. Ovariectomy induced oxidative stress, and estrogen replacement therapy prevented it. These findings provide evidence for estrogen beneficial effects in type 2 diabetes and should be considered when prescribing estrogen replacement therapy to menopausal women.

scholarly journals A Role of Oxidative Stress-Generated Eicosanoid in the Progression of Arteriosclerosis in Type 2 Diabetes Mellitus Model Rats

2002 ◽  
Vol 25 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Kaori SHINOMIYA ◽  
Megumu FUKUNAGA ◽  
Hideyasu KIYOMOTO ◽  
Katsufumi MIZUSHIGE ◽  
Teppei TSUJI ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus

Protective Role of Terminalia superba Ethyl Acetate Extract Against Oxidative Stress in Type 2 Diabetes

Pharmacologia ◽  
2011 ◽  
Vol 2 (12) ◽  
pp. 355-361
Author(s):  
Ngueguim Tsofack Florence ◽  
Tabi Nkoulou Thierry ◽  
Dzeufiet Djomeni Paul Desir ◽  
Tsala David Emeryb ◽  
Dongmo Alain Blaise ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Protective Role ◽  
Terminalia Superba
Sign in / Sign up

Export Citation Format

Share Document