Evaluating the effects of anticoagulant rodenticide bromadiolone in Wistar rats co-exposed to vitamin K: impact on blood–liver axis and brain oxidative status

2021 ◽  
Author(s):  
Damir Suljević ◽  
Saida Ibragić ◽  
Maja Mitrašinović-Brulić ◽  
Muhamed Fočak
Keyword(s):  
Vitamin K ◽  
Wistar Rats ◽  
Oxidative Status ◽  
Anticoagulant Rodenticide

Impact of dietary lipoic acid supplementation on liver mitochondrial bioenergetics and oxidative status on normally fed Wistar rats

2019 ◽  
Vol 70 (7) ◽  
pp. 834-844 ◽  
Author(s):  
M. P. Valdecantos ◽  
P. Pérez-Matute ◽  
P. Prieto-Hontoria ◽  
M. J. Moreno-Aliaga ◽  
J. A. Martínez
Keyword(s):  
Lipoic Acid ◽  
Wistar Rats ◽  
Oxidative Status ◽  
Mitochondrial Bioenergetics ◽  
Acid Supplementation

Haemorrhage in seven cats with suspected anticoagulant rodenticide intoxication

2003 ◽  
Vol 5 (5) ◽  
pp. 295-304 ◽  
Author(s):  
B Kohn ◽  
C Weingart ◽  
U Giger
Keyword(s):  
Body Weight ◽  
Blood Plasma ◽  
Vitamin K ◽  
Whole Blood ◽  
Partial Thromboplastin Time ◽  
Reference Range ◽  
Activated Partial Thromboplastin Time ◽  
Anticoagulant Rodenticide ◽  
Plasma Coagulation ◽  
Adult Cats

Clinical features were evaluated in seven adult cats (six males, one female) with haemorrhage and presumptive anticoagulant rodenticide intoxication. Haemorrhage appeared as thoracic haemorrhage, otic bleeding, haematoma, melena, haematochezia, and petechiation. The most common other presenting signs were lethargy, anorexia, and tachypnoea or dyspnoea. Six cats were anaemic, four cats were mildly thrombocytopenic (58 000–161 000/μl), and three had slightly decreased plasma protein or albumin values. The prothrombin time (30.3–>100 s, reference range: 16.5–27.5 s) and activated partial thromboplastin time values (32.6–>100 s; reference range: 14–25 s) were markedly prolonged in all cats. All cats received vitamin K1 subcutaneously or orally (3.7–5 mg/kg body weight initially) and depending on severity of signs five cats were transfused with fresh whole blood. Plasma coagulation times improved in all cats and returned to normal in 1–5 days. Rodenticide poisons represent an important but relatively rare cause of haemorrhage in cats and can be effectively treated.

Anxiety-related behavior in hyperhomocysteinemia induced by methionine nutritional overload in rats: role of the brain oxidative stress

2016 ◽  
Vol 94 (10) ◽  
pp. 1074-1082 ◽  
Author(s):  
Dragan Hrncic ◽  
Jelena Mikić ◽  
Aleksandra Rasic-Markovic ◽  
Milica Velimirović ◽  
Tihomir Stojković ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Open Field ◽  
Wistar Rats ◽  
Brain Regions ◽  
Oxidative Status ◽  
Standard Diet ◽  
Male Wistar Rats ◽  
Brain Oxidative Stress ◽  
The Brain

The aim of this study was to examine the effects of a methionine-enriched diet on anxiety-related behavior in rats and to determine the role of the brain oxidative status in these alterations. Adult male Wistar rats were fed from the 30th to 60th postnatal day with standard or methionine-enriched diet (double content comparing with standard diet: 7.7 g/kg). Rats were tested in open field and light–dark tests and afterwards oxidative status in the different brain regions were determined. Hyperhomocysteinemia induced by methionine-enriched diet in this study decreased the number of rearings, as well as the time that these animals spent in the center of the open field, but increased index of thigmotaxy. Oxidative status was selectively altered in the examined regions. Lipid peroxidation was significantly increased in the cortex and nc. caudatus of rats developing hyperhomocysteinemia, but unaltered in the hippocampus and thalamus. Based on the results of this research, it could be concluded that hyperhomocysteinemia induced by methionine nutritional overload increased anxiety-related behavior in rats. These proanxiogenic effects could be, at least in part, a consequence of oxidative stress in the rat brain.

scholarly journals HABITUALCAFFEINE CONSUMPTION AND ITS INFLUENCE ON MYOCARDIAL FIBERS, BLOOD PRESSURE AND OXIDATIVE STATUS IN PREGNANT ALBINO WISTAR RATS.

2016 ◽  
Vol 4 (10) ◽  
pp. 1845-1854
Author(s):  
DavidE Ehichioya ◽  
◽  
TolulopeO Oyesola ◽  
RosemaryC Ogbonna ◽  
KolawaleI Ajiboye ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Wistar Rats ◽  
Oxidative Status ◽  
Myocardial Fibers

Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine

2018 ◽  
Vol 165 (6) ◽  
pp. 746-750 ◽  
Author(s):  
T. N. Fedorova ◽  
A. A. Devyatov ◽  
D. S. Berezhnoi ◽  
S. L. Stvolinskii ◽  
M. P. Morozova ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Wistar Rats ◽  
Focal Ischemia ◽  
Oxidative Status

Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats

2020 ◽  
Author(s):  
Oluwatosin Adebisi Dosumu ◽  
Solomon Oladapo Rotimi ◽  
Oluwagbemiga Olanrewaju Adeleye ◽  
Adio Jamiu Akamo ◽  
Kehinde Temitope Osinuga ◽  
...  
Keyword(s):  
Vitamin K ◽  
Wistar Rats

scholarly journals Unifactorial inheritance of warfarin resistance in Rattus norvegicus from Denmark

1977 ◽  
Vol 29 (3) ◽  
pp. 215-222 ◽  
Author(s):  
J. H. Greaves ◽  
P. B. Ayres
Keyword(s):  
Vitamin K ◽  
Rattus Norvegicus ◽  
Major Gene ◽  
Wild Populations ◽  
Anticoagulant Rodenticide ◽  
Vitamin K Deficiency ◽  
Norway Rat ◽  
K Deficiency ◽  
Warfarin Resistance

SUMMARYWild populations of the Norway rat, Rattus norvegicus, in Jutland have been known to be resistant to the anticoagulant rodenticide warfarin since 1962. The inheritance of the resistance was investigated in the F1, backcross and intercross. The results are consistent with the resistance being due to a major gene at the Rw locus. Resistant homozygotes, heterozygotes and susceptible homozygotes appeared to be distinguishable experimentally on the basis of differences in their susceptibility to vitamin K deficiency. The results are discussed in relation to previous studies of the inheritance of warfarin resistance in rats.

Sign in / Sign up

Export Citation Format

Share Document