Outcomes of salvage radiation for recurrent world health organization grade II meningiomas: a retrospective cohort study

Introduction: immunological disorder agent’s area unit theorized to focus on the protein storm syndrome in COVID‑19. However, the downstream effects concerning susceptibilities to secondary infection risk stay unknown. This study seeks to work out risk variations for secondary infections among COVID‑19 patients World Health Organization did and failed to receive tocilizumab. Methods: we have a tendency to conducted a matched retrospective cohort study from 2 giants, acute care hospitals in Western Connecticut from March 1 to May 31, 2020. we have a tendency to collected variables exploitation manual case history abstraction. the first exposure variable was any dose of tocilizumab. the first outcome was any healthcare‑associated microorganism or mycosis as outlined by the National Care Safety Network. we have a tendency to performed a Kaplan–Meier analysis to assess the crude distinction within the additive likelihood of healthcare‑associated infection (HAI) across exposure teams. we have a tendency to conjointly performed a multivariable Cox multivariate analysis to work out the hazard quantitative relation for HAI by exposure group whereas dominant for potential confounders. Results: The Kaplan–Meier analysis incontestable no distinction within the additive likelihood of HAI across teams. The adjusted hazard of HAI for patients given tocilizumab was zero.85 times that of patients not given tocilizumab (95% confidence interval = zero.29, 2.52, P = 0.780) once dominant for relevant confounders. Conclusions: Tocilizumab failed to increase the incidence of secondary infection among COVID‑19 patients. Larger, irregular trials ought to valuate infection as a secondary outcome to validate this finding.

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Revisiting Adjuvant Radiotherapy After Gross Total Resection of World Health Organization Grade II Meningioma

World Neurosurgery ◽

10.1016/j.wneu.2017.04.095 ◽

2017 ◽

Vol 103 ◽

pp. 655-663 ◽

Cited By ~ 25

Author(s):

Christopher S. Graffeo ◽

Heather E. Leeper ◽

Avital Perry ◽

Joon H. Uhm ◽

Daniel J. Lachance ◽

...

Keyword(s):

World Health Organization ◽

Adjuvant Radiotherapy ◽

World Health ◽

Gross Total Resection ◽

Total Resection ◽

Grade Ii ◽

Health Organization

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Estimated Impact of World Health Organization Latent Tuberculosis Screening Guidelines in a Region With a Low Tuberculosis Incidence: Retrospective Cohort Study

Clinical Infectious Diseases ◽

10.1093/cid/ciz188 ◽

2019 ◽

Vol 69 (12) ◽

pp. 2101-2108 ◽

Cited By ~ 6

Author(s):

Lisa A Ronald ◽

Jonathon R Campbell ◽

Caren Rose ◽

Robert Balshaw ◽

Kamila Romanowski ◽

...

Keyword(s):

Risk Factors ◽

World Health Organization ◽

Retrospective Cohort ◽

Latent Tuberculosis ◽

World Health ◽

Administrative Databases ◽

Ltbi Screening ◽

Immunosuppressive Medications ◽

Health Organization ◽

The Impact

Abstract Background Latent tuberculosis infection (LTBI) screening and treatment is a key component of the World Health Organization (WHO) EndTB Strategy, but the impact of LTBI screening and treatment at a population level is unclear. We aimed to estimate the impact of LTBI screening and treatment in a population of migrants to British Columbia (BC), Canada. Methods This retrospective cohort included all individuals (N = 1 080 908) who immigrated to Canada as permanent residents between 1985 and 2012 and were residents in BC at any time up to 2013. Multiple administrative databases were linked to identify people with risk factors who met the WHO strong recommendations for screening: people with tuberculosis (TB) contact, with human immunodeficiency virus, on dialysis, with tumor necrosis factor-alpha inhibitors, who had an organ/haematological transplant, or with silicosis. Additional TB risk factors included immunosuppressive medications, cancer, diabetes, and migration from a country with a high TB burden. We defined active TB as preventable if diagnosed ≥6 months after a risk factor diagnosis. We estimated the number of preventable TB cases, given optimal LTBI screening and treatment, based on these risk factors. Results There were 16 085 people (1.5%) identified with WHO strong risk factors. Of the 2814 people with active TB, 118 (4.2%) were considered preventable through screening with WHO risk factors. Less than half (49.4%) were considered preventable with expanded screening to include people migrating from countries with high TB burdens, people who had been prescribed immunosuppressive medications, or people with diabetes or cancer. Conclusions The application of WHO LTBI strong recommendations for screening would have minimally impacted the TB incidence in this population. Further high-risk groups must be identified to develop an effective LTBI screening and treatment strategy for low-incidence regions.

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Effect of Gross Total Resection in World Health Organization Grade II Astrocytomas: SEER-Based Survival Analysis

World Neurosurgery ◽

10.1016/j.wneu.2017.03.140 ◽

2017 ◽

Vol 103 ◽

pp. 741-747 ◽

Cited By ~ 7

Author(s):

Alexander J. Schupper ◽

Brian R. Hirshman ◽

Kate T. Carroll ◽

Mir Amaan Ali ◽

Bob S. Carter ◽

...

Keyword(s):

Survival Analysis ◽

World Health Organization ◽

World Health ◽

Gross Total Resection ◽

Total Resection ◽

Grade Ii ◽

Health Organization

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Letter to the Editor Regarding “World Health Organization Grade II Meningiomas: The Role of Adjuvant/Salvage Gamma Knife Surgery After Initial Surgery and Prognostic Factor Assessment”

World Neurosurgery ◽

10.1016/j.wneu.2017.11.101 ◽

2018 ◽

Vol 112 ◽

pp. 304

Author(s):

Yi Wang ◽

XiaoPing Gao ◽

Yue Ge

Keyword(s):

Prognostic Factor ◽

World Health Organization ◽

Gamma Knife ◽

Gamma Knife Surgery ◽

World Health ◽

Letter To The Editor ◽

Initial Surgery ◽

Grade Ii ◽

Health Organization

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Temporary disengagement and re-engagement in human immunodeficiency virus care in a rural county serving pastoralist communities in Kenya: a retrospective cohort study

International Health ◽

10.1093/inthealth/ihz049 ◽

2019 ◽

Vol 12 (2) ◽

pp. 95-100

Author(s):

Paul Yonga ◽

Stephen Kalya ◽

Lutgarde Lynen ◽

Tom Decroo

Keyword(s):

Human Immunodeficiency Virus ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Retention In Care ◽

Virologic Response ◽

World Health ◽

Hiv Care ◽

Pastoralist Communities ◽

Immunodeficiency Virus

Abstract Background Pastoralist communities are known to be hard to reach. The magnitude of temporary disengagement from human immunodeficiency virus (HIV) care is understudied. Methods We conducted a retrospective cohort study of temporary disengagement (2 weeks late for a next appointment), virologic response, lost to follow-up (6 months late) and re-engagement in care among patients who started antiretroviral therapy between 2014 and 2016 in Baringo County, Kenya. Predictors of re-engagement after disengagement were estimated using logistic regression. Results Of 342 patients, 76.9% disengaged at least once (range 0–7). Of 218 patients with a viral load (VL), 78.0% had a suppressed VL. Those with a history of temporary disengagement from care were less likely to suppress their VL (p=0.002). Six patients had treatment failure (two consecutive VLs >1000 copies/mm3) and all had disengaged at least once. After disengagement from care, male patients (adjusted odds ratio [aOR] 0.3 [95% confidence interval {CI} 0.2 to 0.6]; p<0.001) and patients with World Health Organization stage III–IV (aOR 0.3 [95% CI 0.1 to 0.5; p<0.001) were less likely to re-engage in care. Conclusions Temporary disengagement was frequent in this pastoralist setting. This indicator is often overlooked, as most studies only report binary outcomes, such as retention in care. Innovative strategies are required to achieve HIV control in rural settings like this pastoralist setting.

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Long-term brain plasticity allowing a multistage surgical approach to World Health Organization Grade II gliomas in eloquent areas

Journal of Neurosurgery ◽

10.3171/jns/2008/109/10/0615 ◽

2008 ◽

Vol 109 (4) ◽

pp. 615-624 ◽

Cited By ~ 161

Author(s):

Santiago Gil Robles ◽

Peggy Gatignol ◽

Stéphane Lehéricy ◽

Hugues Duffau

Keyword(s):

World Health Organization ◽

Surgical Approach ◽

Brain Plasticity ◽

Extent Of Resection ◽

World Health ◽

Eloquent Areas ◽

Grade Ii ◽

Brain Reorganization ◽

Health Organization ◽

Intraoperative Electrical Stimulation

Although the goal of surgery for World Health Organization Grade II gliomas is maximal extent of resection, complete tumor removal is not always possible when the glioma involves eloquent areas. The authors propose a multistage surgical approach to highly crucial areas that are classically considered inoperable, enabling optimization of the extent of resection while avoiding permanent cognitive deficits due to induced functional reshaping in the interim between the 2 consecutive operations. To demonstrate such plasticity, the authors used a combination of sequential functional MR imaging and intraoperative electrical stimulation mapping before and during surgeries spaced by several years in 2 patients who each underwent 2 separate resections of Grade II gliomas located in the left dominant premotor area. During several years of follow-up after the first procedure, both patients had unremarkable examination results and normal socioprofessional lives. There was no malignant transformation. Based on their experience with these cases, the authors suggest that in cases of incomplete glioma removal, a second operation before anaplasia should be considered, made possible by brain reorganization after the first operation.

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