scholarly journals Validation of the updated renal graded prognostic assessment (GPA) for patients with renal cancer brain metastases treated with gamma knife radiosurgery

2021 ◽  
Author(s):  
Niels J. van Ruitenbeek ◽  
Vincent K. Y. Ho ◽  
Hans M. Westgeest ◽  
Laurens V. Beerepoot ◽  
Patrick E. J. Hanssens
Keyword(s):  
Brain Metastases ◽  
Gamma Knife ◽  
Renal Cancer ◽  
Gamma Knife Radiosurgery ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment

scholarly journals Validation of the Updated Renal Graded Prognostic Assessment (GPA) for patients with renal cancer brain metastases treated with Gamma Knife radiosurgery

2021 ◽  
Author(s):  
Niels van Ruitenbeek ◽  
Vincent Ho ◽  
Hans Westgeest ◽  
Laurens Beerepoot ◽  
Patrick Hanssens
Keyword(s):  
Brain Metastasis ◽  
Disease Progression ◽  
Gamma Knife ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Gamma Knife Radiosurgery ◽  
Local Failure ◽  
Prognostic Assessment ◽  
Intracranial Disease ◽  
Graded Prognostic Assessment

Abstract Introduction: Prognosis of patients with brain metastasis (BM) from renal cell carcinoma (RCC) is relevant for treatment decisions and can be estimated with the Renal Graded Prognostic Assessment (GPA). The aim of this study is to validate the updated version of this instrument in a cohort treated with Gamma Knife radiosurgery (GKRS) without prior local intracerebral therapy. Methods: Between 2007 and 2018, 100 RCC patients with BM were treated with GKRS. They were categorized according to the updated Renal GPA. Overall survival (OS), intracranial disease progression and intracranial local failure were estimated using the Kaplan-Meier method and risk factors were identified with Cox proportional hazard regressions. Results: Median OS was 10.4 months. Median OS for GPA categories 0.0-1.0 (10%), 1.5-2.0 (13%), 2.5-3.0 (37%) and 3.5-4.0 (31%) was 2.9, 5.5, 8.1 and 20.4 months, respectively. Karnofsky performance status <90, serum hemoglobin ≤12.5 g/dL, age >65 years and time from primary diagnosis to brain metastasis <1 year were significantly related with shorter survival, while presence of extracranial disease, the volume and total number of BM had no impact on OS. A total count of >4 BM was the only predictive factor for intracranial disease progression, while none of the investigated factors predicted intracranial local failure. Conclusions: This study confirms the updated Renal GPA in an independent cohort as a valuable instrument to estimate survival in patients with BM from RCC treated with GKRS.

Gamma knife radiosurgery for renal cell carcinoma brain metastases

2002 ◽  
Vol 97 ◽  
pp. 489-493 ◽  
Author(s):  
Laura Hernandez ◽  
Lucia Zamorano ◽  
Andrew Sloan ◽  
James Fontanesi ◽  
Simon Lo ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Gamma Knife ◽  
Median Survival ◽  
Renal Cell ◽  
Univariate Analysis ◽  
Gamma Knife Radiosurgery ◽  
Content Type ◽  
Fine Print

Object. The purpose of this study was to clarify the effectiveness of gamma knife radiosurgery (GKS) in achieving a partial or complete remission of so-called radioresistant metastases from renal cell carcinoma (RCC) and to propose guidelines for optimal treatment Methods. During a 5-year period, 29 patients (19 male and 10 female) with 92 brain metastases from RCC underwent GKS. The median tumor volume was 4.7 cm3 (range 0.5–14.5 cm3). Fourteen patients (48%) also underwent whole-brain radiotherapy (WBRT) before GKS, and two patients (6.8%) after GKS. The mean GKS dose delivered to the 50% isodose at the tumor margin was 16.8 Gy (range 13–30 Gy). All cases were categorized according to the Recursive Partitioning Analysis (RPA) classification for brain metastases. Univariate analysis was performed to determine significant prognostic factors and survival. The overall median survival was 7 months after GKS treatment. Age, sex, Karnofsky Performance Scale score, and controlled primary disease were not predictors of survival. Combined WBRT/GKS resulted in median survival of 18, 8.5, and 5.3 months for RPA Classes I, II, and III, respectively, compared with the median survival 7.1, 4.2, and 2.3 months for patients treated with WBRT alone. Conclusions. These results suggest that WBRT combined with GKS may improve survival in patients with brain metastases from RCC. Furthermore, this improvement in survival was seen in all RPA classes.

scholarly journals Ten-Year Survival of a Patient Treated with Stereotactic Gamma Knife Radiosurgery for Brain Metastases from Colon Cancer with Ovarian and Lymph Node Metastases: A Case Report

2016 ◽  
Vol 10 (1) ◽  
pp. 204-211 ◽  
Author(s):  
Nobuhiro Morinaga ◽  
Naritaka Tanaka ◽  
Yoshinori Shitara ◽  
Masatoshi Ishizaki ◽  
Takatomo Yoshida ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Sigmoid Colon ◽  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Sigmoid Colon Cancer ◽  
Ovarian Lesion ◽  
Node Metastases

Brain metastasis from colorectal cancer is infrequent and carries a poor prognosis. Herein, we present a patient alive 10 years after the identification of a first brain metastasis from sigmoid colon cancer. A 39-year-old woman underwent sigmoidectomy for sigmoid colon cancer during an emergency operation for pelvic peritonitis. The pathological finding was moderately differentiated adenocarcinoma. Eleven months after the sigmoidectomy, a metastatic lesion was identified in the left ovary. Despite local radiotherapy followed by chemotherapy, the left ovarian lesion grew, so resection of the uterus and bilateral ovaries was performed. Adjuvant chemotherapy with tegafur-uracil (UFT)/calcium folinate (leucovorin, LV) was initiated. Seven months after resection of the ovarian lesion, brain metastases appeared in the bilateral frontal lobes and were treated with stereotactic Gamma Knife radiosurgery. Cervical and mediastinal lymph node metastases were also diagnosed, and irradiation of these lesions was performed. After radiotherapy, 10 courses of oxaliplatin and infused fluorouracil plus leucovorin (FOLFOX) were administered. During FOLFOX administration, recurrent left frontal lobe brain metastasis was diagnosed and treated with stereotactic Gamma Knife radiosurgery. In this case, the brain metastases were well treated with stereotactic Gamma Knife radiosurgery, and the systemic disease arising from sigmoid colon cancer has been kept under control with chemotherapies, surgical resection, and radiotherapy.

scholarly journals Estimating survival for renal cell carcinoma patients with brain metastases: an update of the Renal Graded Prognostic Assessment tool

2018 ◽  
Vol 20 (12) ◽  
pp. 1652-1660 ◽  
Author(s):  
Paul W Sperduto ◽  
Brian J Deegan ◽  
Jing Li ◽  
Krishan R Jethwa ◽  
Paul D Brown ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Brain Metastases ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Assessment Tool ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment

scholarly journals Development of a disease-specific graded prognostic assessment index for the management of sarcoma patients with brain metastases (Sarcoma-GPA)

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Anna Patrikidou ◽  
Loic Chaigneau ◽  
Nicolas Isambert ◽  
Kyriaki Kitikidou ◽  
Ryan Shanley ◽  
...  
Keyword(s):  
Brain Metastases ◽  
Assessment Index ◽  
Prognostic Assessment ◽  
Graded Prognostic Assessment ◽  
Disease Specific
Sign in / Sign up

Export Citation Format

Share Document