Extracellular Protein Interactions Mediated by the Neural Cell Adhesion Molecule, NCAM: Heterophilic Interactions Between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and Viruses

2008 ◽  
Author(s):  
Janne Nielsen ◽  
Nikolaj Kulahin ◽  
Peter S. Walmod
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Protein Interactions ◽  
Cell Adhesion Molecules ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Matrix Proteins ◽  
Neural Cell Adhesion

scholarly journals The Neural Cell Adhesion Molecule L1 Potentiates Integrin-Dependent Cell Migration to Extracellular Matrix Proteins

2002 ◽  
Vol 22 (12) ◽  
pp. 4918-4931 ◽  
Author(s):  
Karsten Thelen ◽  
Vishram Kedar ◽  
Anitha K. Panicker ◽  
Ralf-Steffen Schmid ◽  
Bentley R. Midkiff ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Migration ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Matrix Proteins ◽  
Neural Cell Adhesion ◽  
Dependent Cell ◽  
Cell Adhesion Molecule L1

scholarly journals Interactions of the neural cell adhesion molecule and the myelin-associated glycoprotein with collagen type I: involvement in fibrillogenesis.

1992 ◽  
Vol 116 (4) ◽  
pp. 1063-1070 ◽  
Author(s):  
R Probstmeier ◽  
T Fahrig ◽  
E Spiess ◽  
M Schachner
Keyword(s):  
Extracellular Matrix ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Collagen Type ◽  
Collagen Type I ◽  
Type I ◽  
Neural Cell Adhesion ◽  
Myelin Associated Glycoprotein

To gain insights into the functional role of the molecular association between neural adhesion molecules and extracellular matrix constituents, soluble forms of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM), representing most of the extracellular domains of the molecules, were investigated in their ability to modify fibrillogenesis of collagen type I. MAG and N-CAM retarded the rate of fibril formation, as measured by changes in turbidity, and increased the diameter of the fibrils formed, but did not change the banding pattern when compared to collagen type I in the absence of adhesion molecules. Scatchard plot analysis of the binding of MAG and N-CAM to the fibril-forming collagen types I, II, III, and V suggest one binding site for N-CAM and two binding sites for MAG. Binding of MAG, but not of N-CAM, to collagen type I was decreased during fibril formation, probably due to a reduced accessibility of one binding site for MAG during fibrillogenesis. These results indicate that the neural adhesion molecules can influence the configuration of extracellular matrix constituents, thus, implicating them in the modulation of cell-substrate interactions.

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