Adaptation of dynamical properties of time series data and its applications in deep brain stimulation

2020 ◽  
Vol 99 (4) ◽  
pp. 3231-3251
Author(s):  
Syed Aamir Ali Shah ◽  
Abdul Bais ◽  
Lei Zhang
2021 ◽  
Vol 15 ◽  
Author(s):  
Witney Chen ◽  
Lowry Kirkby ◽  
Miro Kotzev ◽  
Patrick Song ◽  
Ro’ee Gilron ◽  
...  

Advances in neuromodulation technologies hold the promise of treating a patient’s unique brain network pathology using personalized stimulation patterns. In service of these goals, neuromodulation clinical trials using sensing-enabled devices are routinely generating large multi-modal datasets. However, with the expansion of data acquisition also comes an increasing difficulty to store, manage, and analyze the associated datasets, which integrate complex neural and wearable time-series data with dynamic assessments of patients’ symptomatic state. Here, we discuss a scalable cloud-based data platform that enables ingestion, aggregation, storage, query, and analysis of multi-modal neurotechnology datasets. This large-scale data infrastructure will accelerate translational neuromodulation research and enable the development and delivery of next-generation deep brain stimulation therapies.


2015 ◽  
Vol 2 (4) ◽  
pp. 1301-1315
Author(s):  
E. Lynch ◽  
D. Kaufman ◽  
A. S. Sharma ◽  
E. Kalnay ◽  
K. Ide

Abstract. Bred vectors characterize the nonlinear instability of dynamical systems and so far have been computed only for systems with known evolution equations. In this article, bred vectors are computed from a single time series data using time-delay embedding, with a new technique, nearest-neighbor breeding. Since the dynamical properties of the standard and nearest-neighbor breeding are shown to be similar, this provides a new and novel way to model and predict sudden transitions in systems represented by time series data alone.


2016 ◽  
Vol 23 (3) ◽  
pp. 137-141 ◽  
Author(s):  
Erin Lynch ◽  
Daniel Kaufman ◽  
A. Surjalal Sharma ◽  
Eugenia Kalnay ◽  
Kayo Ide

Abstract. Bred vectors characterize the nonlinear instability of dynamical systems and so far have been computed only for systems with known evolution equations. In this article, bred vectors are computed from a single time series data using time-delay embedding, with a new technique, nearest-neighbor breeding. Since the dynamical properties of the standard and nearest-neighbor breeding are shown to be similar, this provides a new and novel way to model and predict sudden transitions in systems represented by time series data alone.


2018 ◽  
Vol 75 (7) ◽  
pp. 448-454
Author(s):  
Thomas Grunwald ◽  
Judith Kröll

Zusammenfassung. Wenn mit den ersten beiden anfallspräventiven Medikamenten keine Anfallsfreiheit erzielt werden konnte, so ist die Wahrscheinlichkeit, dies mit anderen Medikamenten zu erreichen, nur noch ca. 10 %. Es sollte dann geprüft werden, warum eine Pharmakoresistenz besteht und ob ein epilepsiechirurgischer Eingriff zur Anfallsfreiheit führen kann. Ist eine solche Operation nicht möglich, so können palliative Verfahren wie die Vagus-Nerv-Stimulation (VNS) und die tiefe Hirnstimulation (Deep Brain Stimulation) in eine bessere Anfallskontrolle ermöglichen. Insbesondere bei schweren kindlichen Epilepsien stellt auch die ketogene Diät eine zu erwägende Option dar.


2008 ◽  
Author(s):  
Jonathan D. Richards ◽  
Paul M. Wilson ◽  
Pennie S. Seibert ◽  
Carin M. Patterson ◽  
Caitlin C. Otto ◽  
...  

2013 ◽  
Author(s):  
Stephen J. Tueller ◽  
Richard A. Van Dorn ◽  
Georgiy Bobashev ◽  
Barry Eggleston

2009 ◽  
Author(s):  
Hunter Covert ◽  
Pennie S. Seibert ◽  
Caitlin C. Otto ◽  
Missy Coblentz ◽  
Nicole Whitener ◽  
...  

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