Linking the RCADS-25 to the PROMIS® pediatric item banks Anxiety and Depressive Symptoms in a general Dutch population sample

BackgroundMany people suffering from mental disorders do not seek appropriate help. We have examined attitudes that further or hinder help-seeking for depression with an established socio-psychological model, the Theory of Planned Behaviour (TPB), comparing models for respondents with and without depressive symptoms.MethodA qualitative preparatory study (n=29) elicited salient behavioural (BB), normative (NB) and control beliefs (CB) that were later included in the TPB questionnaire. Telephone interviews with a representative population sample in Germany (n=2303) started with a labelled vignette describing symptoms of a major depression, followed by items covering the components of the TPB. Intention to see a psychiatrist for the problem described was elicited at the beginning and at the end of the interview. We screened participants for current depressive symptoms using the mood subscale of the Patient Health Questionnaire (PHQ-9).ResultsIn non-depressed respondents (n=2167), a TPB path model predicted 42% of the variance for the first and 51% for the second question on intention. In an analogous model for depressed respondents (n=136), these values increased to 50% and 61% respectively. Path coefficients in both models were similar. In both depressed and non-depressed persons, attitude towards the behaviour was more important than the subjective norm, whereas perceived behavioural control was of minor influence.ConclusionsWillingness to seek psychiatric help for depression can largely be explained by a set of attitudes and beliefs as conceptualized by the TPB. Our findings suggest that changing attitudes in the general population are likely to effect help-seeking when people experience depressive symptoms.

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Psychometric properties of the Dutch-Flemish PROMIS® pediatric item banks Anxiety and Depressive Symptoms in a general population

Quality of Life Research ◽

10.1007/s11136-021-02852-y ◽

2021 ◽

Author(s):

L. H. Klaufus ◽

M. A. J. Luijten ◽

E. Verlinden ◽

M. F. van der Wal ◽

L. Haverman ◽

...

Keyword(s):

Depressive Symptoms ◽

General Population ◽

Psychometric Properties ◽

Item Banks

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Prevalence of medicinal drugs in suspected impaired drivers and a comparison with the use in the general Dutch population

Forensic Science International ◽

10.1016/j.forsciint.2014.06.004 ◽

2014 ◽

Vol 241 ◽

pp. 203-211 ◽

Cited By ~ 10

Author(s):

Karlijn D.B. Bezemer ◽

Beitske E. Smink ◽

Rianne van Maanen ◽

Miranda Verschraagen ◽

Johan J. de Gier

Keyword(s):

Dutch Population ◽

General Dutch Population ◽

Medicinal Drugs

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Exploring negative affect dynamics in high resolution: within-person relationship of inertia and instability with depression is mediated by affect intensity

10.31234/osf.io/he53c ◽

2021 ◽

Author(s):

Levente Rónai ◽

Bertalan Polner

Keyword(s):

Depressive Symptoms ◽

Multilevel Models ◽

Negative Mood ◽

Population Sample ◽

Self Report ◽

Affective States ◽

Affect Intensity ◽

Individual Level ◽

Affective Functioning ◽

Affect Dynamics

Background: Temporal patterns of affective functioning such as emotional inertia and instability may indicate changes in emotion regulation that predict depression. However, affect dynamics’ incremental validity over affect intensity and exposure to stressors in predicting depression has been questioned.Methods: We collected longitudinal data regarding momentary affective states (measured multiple times a day), perceived stressors and depressive symptoms (measured every three days) from a general population sample during the COVID-19 pandemic’s first wave in Hungary. The final dataset included 7165 affective states surveys from 125 participants, which were aggregated in 464 three-day measurement windows. Using multilevel models, we explored the unique effects of within-person changes in mean level, inertia, and instability of negative affective states (NA), and stressor-exposure on two domains of depression (anhedonia and negative mood and thoughts) within the three-day windows.Results: Within-person increases in NA inertia and NA instability showed significant positive associations with negative mood and thoughts. These effects did not remain significant after adjusting for mean levels of NA. Multilevel mediation analysis revealed that within individuals, NA inertia and instability indirectly predicted negative mood and thoughts through elevated NA mean.Limitations: The application of self-report questionnaires might bias the results, and the overrepresentation of female participants could limit the generalizability of the findings.Conclusions: Specific patterns of temporal affective functioning are indirect predictors of depressive symptoms at the within-individual level. Our findings may facilitate automated depression risk assessment on the basis of simple affective time series.

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Every Night and Every Morn: Effect of Variation in CLOCK Gene on Depression Depends on Exposure to Early and Recent Stress

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.687487 ◽

2021 ◽

Vol 12 ◽

Author(s):

Dorka Gyorik ◽

Nora Eszlari ◽

Zsofia Gal ◽

Dora Torok ◽

Daniel Baksa ◽

...

Keyword(s):

Depressive Symptoms ◽

Linkage Disequilibrium ◽

Life Events ◽

Negative Life Events ◽

Population Sample ◽

Brief Symptom Inventory ◽

Additive Models ◽

Outcome Variable ◽

Childhood Adversities ◽

Increased Risk

The role of circadian dysregulation is increasingly acknowledged in the background of depressive symptoms, and is also a promising treatment target. Similarly, stress shows a complex relationship with the circadian system. The CLOCK gene, encoding a key element in circadian regulation has been implicated in previous candidate variant studies in depression with contradictory findings, and only a few such studies considered the interacting effects of stress. We investigated the effect of CLOCK variation with a linkage-disequilibrium-based clumping method, in interaction with childhood adversities and recent negative life events, on two phenotypes of depression, lifetime depression and current depressive symptoms in a general population sample.Methods: Participants in NewMood study completed questionnaires assessing childhood adversities and recent negative life events, the Brief Symptom Inventory to assess current depressive symptoms, provided data on lifetime depression, and were genotyped for 1054 SNPs in the CLOCK gene, 370 of which survived quality control and were entered into linear and logistic regression models with current depressive symptoms and lifetime depression as the outcome variable, and childhood adversities or recent life events as interaction variables followed by a linkage disequilibrium-based clumping process to identify clumps of SNPs with a significant main or interaction effect.Results: No significant clumps with a main effect were found. In interaction with recent life events a significant clump containing 94 SNPs with top SNP rs6825994 for dominant and rs6850524 for additive models on current depression was identified, while in interaction with childhood adversities on current depressive symptoms, two clumps, both containing 9 SNPs were found with top SNPs rs6828454 and rs711533.Conclusion: Our findings suggest that CLOCK contributes to depressive symptoms, but via mediating the effects of early adversities and recent stressors. Given the increasing burden on circadian rhythmicity in the modern lifestyle and our expanding insight into the contribution of circadian disruption in depression especially as a possible mediator of stress, our results may pave the way for identifying those who would be at an increased risk for depressogenic effects of circadian dysregulation in association with stress as well as new molecular targets for intervention in stress-related psychopathologies in mood disorders.

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Patterns of food consumption and risk factors for cardiovascular disease in the general Dutch population

American Journal of Clinical Nutrition ◽

10.1093/ajcn/77.5.1156 ◽

2003 ◽

Vol 77 (5) ◽

pp. 1156-1163 ◽

Cited By ~ 139

Author(s):

Rob M van Dam ◽

Linda Grievink ◽

Marga C Ocké ◽

Edith JM Feskens

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Food Consumption ◽

Dutch Population ◽

General Dutch Population

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Survival of Surgically Treated Infective Endocarditis: A Comparison With the General Dutch Population

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2011.02.007 ◽

2011 ◽

Vol 91 (5) ◽

pp. 1407-1412 ◽

Cited By ~ 31

Author(s):

M. Mostafa Mokhles ◽

Isabella Ciampichetti ◽

Stuart J. Head ◽

Johanna J.M. Takkenberg ◽

Ad J.J.C. Bogers

Keyword(s):

Infective Endocarditis ◽

Dutch Population ◽

General Dutch Population

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Reproductive risks in 35-year-old adults born very preterm and/or with very low birth weight: an observational study

European Journal of Pediatrics ◽

10.1007/s00431-020-03864-5 ◽

2020 ◽

Author(s):

Sylvia M. van der Pal ◽

Sanne A. van der Meulen ◽

Sophie M. Welters ◽

Leonhard A. Bakker ◽

Christianne J. M. de Groot ◽

...

Keyword(s):

Birth Weight ◽

Pregnancy Complications ◽

Very Low Birth Weight ◽

Reproductive Rate ◽

Elevated Risk ◽

Dutch Population ◽

Very Preterm ◽

Increased Risk ◽

General Dutch Population ◽

Fertility Problems

Abstract Evidence suggests that increased survival over the last decades of very preterm (VPT; gestational age < 32 weeks)– and very low birth weight (VLBW; birth weight < 1500 g)–born infants is not matched by improved outcomes. The objective of our study was to evaluate the reproductive rate, fertility, and pregnancy complications in 35-year-old VPT/VLBW subjects. All Dutch VPT/VLBW infants born alive in 1983 and surviving until age 35 (n = 955) were eligible for a POPS-35 study. A total of 370 (39%) subjects completed a survey on reproductive rate, fertility problems, pregnancy complications, and perinatal outcomes of their offspring. We tested differences in these parameters between the VPT/VLBW subjects and their peers from Dutch national registries. POPS-35 participants had less children than their peers in the CBS registry. They reported more problems in conception and pregnancy complications, including a three times increased risk of hypertension during pregnancy. Conclusion: Reproduction is more problematic in 35-year olds born VPT/VLBW than in the general population, possibly mediated by an increased risk for hypertension, but their offspring have no elevated risk for preterm birth. What is known:At age 28, the Dutch national POPS cohort, born very preterm or with a very low birth in 1983, had lower reproductive rates than the general Dutch population (female 23% versus 32% and male 7% versus 22%).What is new:At age 35, the Dutch POPS cohort still had fewer children than the general Dutch population (female 56% versus 74% and male 40% versus 56%). Females in the POPS cohort had a higher risk of fertility problems and pregnancy complications than their peers in the Dutch national registries, but their offspring had no elevated risk for preterm birth.

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