Genotoxicity evaluation using micronucleus test in Rattus norvegicus captured in urban ecosystems of Buenos Aires, Argentina

2020 ◽  
Vol 27 (22) ◽  
pp. 27626-27634
Author(s):  
Mariel Alejandra Tripodi ◽  
Nancy Beatriz Andrioli ◽  
Olga Virginia Suárez
Keyword(s):  
Rattus Norvegicus ◽  
Buenos Aires ◽  
Micronucleus Test ◽  
Urban Ecosystems

scholarly journals Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

2014 ◽  
Vol 50 (2) ◽  
pp. 251-256
Author(s):  
Igor Vivian de Almeida ◽  
Giovana Domingues ◽  
Lilian Capelari Soares ◽  
Elisângela Düsman ◽  
Veronica Elisa Pimenta Vicentini
Keyword(s):  
Rattus Norvegicus ◽  
Bone Marrow Cells ◽  
Micronucleus Test ◽  
Term Treatment ◽  
Genotoxic Effects ◽  
Short Term ◽  
Short Term Treatment ◽  
Chromosomal Aberration Test

Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine. Thus, the aim of this study was to evaluate the cytotoxic, clastogenic and aneugenic effects of FNZ in hepatoma cells from Rattus norvegicus (HTC) in vitro and in bone marrow cells of Wistar rats in vivo. These effects were examined in vitro following treatment with 0.2, 1.0, 5.0 or 10 μg/mL FNZ using a micronucleus test with a cytokinesis block or in vivo using a chromosomal aberration test following treatment with 7, 15 or 30 μg/mL/kg body weight. The results showed that the benzodiazepine concentrations tested were not cytotoxic, aneugenic or clastogenic. However, considering the adverse effects of using this benzodiazepine, more studies are required.

scholarly journals CONNECTIVITY AMONG NORWAY RAT SUBPOPULATIONS (RATTUS NORVEGICUS) AT POULTRY FARMS IN EXALTACIÓN DE LA CRUZ, BUENOS AIRES, ARGENTINA

2019 ◽  
Vol 26 (2) ◽  
pp. 359-367
Author(s):  
Isabel E. Gómez Villafañe ◽  
Noelia Guzmán ◽  
Natalia Ortiz ◽  
Raúl E. González-Ittig ◽  
Vanina. A. León ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Buenos Aires ◽  
Norway Rat ◽  
Poultry Farms

scholarly journals Dental curing light: non-ionizing electromagnetic radiation and its possible genotoxic effects

2020 ◽  
Vol 9 (10) ◽  
pp. e4609108884
Author(s):  
Michele de Sampaio Sousa ◽  
Laryssa Roque da Silva ◽  
Danniel Cabral Leão Ferreira ◽  
Fabrício Pires Moura do Amaral ◽  
Rosemarie Brandim Marques ◽  
...  
Keyword(s):  
Comet Assay ◽  
Rattus Norvegicus ◽  
Micronucleus Test ◽  
Clinical Care ◽  
Positive Control ◽  
Distilled Water ◽  
Test Results ◽  
Control Groups ◽  
Genotoxic Effects ◽  
Curing Light

Objective: In this scientific study, we aimed to evaluate genotoxic effects in rats (Rattus norvegicus), related to different periods of exposures to the LED curing light. Methodology: For the genotoxicity evaluation, the rats received lights from the LED photopolymerizer for 40 sec, 10 min and 7-and-a-half minutes, while the negative and positive control groups were treated with distilled water and cyclophosphamide by intraperitoneal, respectively. A sample of peripheral blood was collected from the animals for the comet assay. The bone marrow was collected from each rat for the micronucleus test. Results: It was observed that in the comet assay and micronucleus test, the animals exposed to LED for 10 min, showed genotoxic damage, and they have not presented toxicity degree in the periods of 40 sec and 7-and-a-half minutes. Conclusion: It is possible to conclude that, there was genotoxic effects on the animals' teeth when exposed to the LED curing light in 10 min. However, in the periods of 40 sec, and 7- and-a-half minutes, have been not observed genotoxic effects. This means these times are safe for professional dentists in clinical care.

scholarly journals Factores ecoambientales relacionados con potenciales reservorios de Leptospira spp. en la Reserva Ecológica Costanera Sur, Buenos Aires, Argentina

2021 ◽  
Vol 1 (43) ◽  
pp. 19-20
Author(s):  
Yanina Berra ◽  
Gastón Arocena ◽  
Carolina Artuso ◽  
Jessica Petrakovsky ◽  
Marcela Orozco ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Buenos Aires ◽  
Leptospira Spp ◽  
Oligoryzomys Flavescens ◽  
Didelphis Albiventris

Las modificaciones ambientales generan entornos de interfaz en los que la transmisión de Leptospira spp. puede verse afectada. Con el objetivo de identificar y analizar variables ecoambientales asociadas a potenciales reservorios de Leptospira spp. en la Reserva Ecológica Costanera Sur (RECS) (Buenos Aires, Argentina) y áreas urbanizadas contiguas, se realizó un muestreo por conveniencia en líneas transectas, estratificado y proporcionado. Fueron capturados 170 mamíferos de 11 especies y se analizó la presencia de Leptospira spp. por serología, cultivo y PCR. En áreas conservadas, se registraron mayormente Didelphis albiventris y Deltamys kempi, mientras que el Oligoryzomys flavescens también fue hallado en áreas degradadas, y la Rattus norvegicus solo fue encontrada en áreas degradadas. No se detectó Leptospira spp. en los mamíferos silvestres. Un perro sin tenedor responsable resultó positivo por ser0ología. Las condiciones ambientales de la RECS sugieren un ecosistema poco propicio para Rattus, evidenciando la importancia de la conservación de áreas naturales en entornos urbanos.

scholarly journals Endoparasite community of Rattus norvegicus captured in a shantytown of Buenos Aires City, Argentina

2011 ◽  
Vol 48 (3) ◽  
pp. 167-173 ◽  
Author(s):  
D. Hancke ◽  
G. Navone ◽  
O. Suarez
Keyword(s):  
Urban Area ◽  
Rattus Norvegicus ◽  
Parasite Species ◽  
Buenos Aires ◽  
The Public ◽  
Potential Reservoir ◽  
Brown Rat ◽  
Zoonotic Parasites ◽  
Buenos Aires City

AbstractThe aim of this study was to evaluate the role of the brown rat (Rattus norvegicus) as a potential reservoir of zoonotic parasites in an urban area of Argentina. A parasitological survey in 40 brown rats trapped in a shantytown of Buenos Aires City was carried out. 97.5 % of the analyzed rats were parasitized with at least one of the 12 species of helminth or protozoan species recorded. Among the species identified, Hymenolepis nana is recognized as one of the most common human helminthes parasites. The average number of parasite species was higher in males than females rats, and in the last case, a direct relationship between parasite species richness and host’s body size was recorded. Variations in endoparasite community throughout the year seasons were recorded, probably related to environmental factors, which limits the performance of the life cycle of different parasite species. The presence of zoonotic endoparasites confirms R. norvegicus as a reservoir for different types of pathologies, which, therefore, represents a risk to the public health in an overcrowded urban area.

scholarly journals Brown rats (Rattus norvegicus) in urban ecosystems: are the constraints related to fieldwork a limit to their study?

2018 ◽  
Vol 21 (5) ◽  
pp. 951-964 ◽  
Author(s):  
Amélie Desvars-Larrive ◽  
Mario Baldi ◽  
Theresa Walter ◽  
Richard Zink ◽  
Chris Walzer
Keyword(s):  
Rattus Norvegicus ◽  
Urban Ecosystems

scholarly journals Identificación morfológica y molecular de Cysticercus fasciolaris aislado de un roedor (Rattus norvegicus) de la provincia de Buenos Aires (Argentina)

2013 ◽  
Vol 45 (3) ◽  
pp. 150-153
Author(s):  
Mara L. Martínez ◽  
Mariana G. Domínguez ◽  
Gabriel E. Morici ◽  
Regino Cavia ◽  
Daniela P. Montes de Oca ◽  
...  
Keyword(s):  
Rattus Norvegicus ◽  
Buenos Aires ◽  
Cysticercus Fasciolaris

Analysis of lead pollution levels within an urban ecosystem using the cestode Hymenolepis diminuta and its rat hosts as bioindicators

2017 ◽  
Vol 92 (5) ◽  
pp. 544-548 ◽  
Author(s):  
M.A. Tripodi ◽  
D. Hancke ◽  
O.V. Suarez
Keyword(s):  
Inductively Coupled Plasma ◽  
Buenos Aires ◽  
Lead Concentration ◽  
Urban Ecosystems ◽  
Urban Ecosystem ◽  
Lead Contamination ◽  
Hymenolepis Diminuta ◽  
Tissue Type ◽  
Lead Pollution ◽  
The City

AbstractThe overall goal of this study was to use the Rattus spp./Hymenolepis diminuta model to assess environmental lead pollution in different landscape units of an urban ecosystem. Rats of the genus Rattus were collected from three shanty towns and three residential neighbourhoods of the city of Buenos Aires. Concentrations of lead in the livers of wild rats and in their parasite H. diminuta were measured using inductively coupled plasma mass spectrometry (ICP-MS). The landscape unit and tissue type had a significant effect on lead concentration, being higher in residential neighbourhoods as well as in H. diminuta tissue. Nevertheless, no significant differences were found for the mean lead concentration in livers between uninfected and infected rats. Since the available information describing heavy-metal pollution within the city of Buenos Aires is scarce, the results of this study allow us to update data about the extent of biologically available lead contamination. Considering that rats and H. diminuta are distributed worldwide, this monitoring system for lead pollution might be applied successfully in other urban ecosystems.

scholarly journals Prevalence of hantavirus infection in wild Rattus norvegicus and R. rattus populations of Buenos Aires City, Argentina

2008 ◽  
Vol 13 (1) ◽  
pp. 46-51 ◽  
Author(s):  
Gerardo Rubén Cueto ◽  
Regino Cavia ◽  
Carla Bellomo ◽  
Paula Julieta Padula ◽  
Olga Virginia Suárez
Keyword(s):  
Rattus Norvegicus ◽  
Buenos Aires ◽  
Hantavirus Infection ◽  
Buenos Aires City

Open discussion

1982 ◽  
Vol 99 ◽  
pp. 605-613
Author(s):  
P. S. Conti
Keyword(s):  
Buenos Aires ◽  
Large Mass ◽  
List Type ◽  
Common Phenomenon ◽  
Open Discussion ◽  
The Stability ◽  
Ring Nebulae

Conti: One of the main conclusions of the Wolf-Rayet symposium in Buenos Aires was that Wolf-Rayet stars are evolutionary products of massive objects. Some questions:–Do hot helium-rich stars, that are not Wolf-Rayet stars, exist?–What about the stability of helium rich stars of large mass? We know a helium rich star of ∼40 MO. Has the stability something to do with the wind?–Ring nebulae and bubbles : this seems to be a much more common phenomenon than we thought of some years age.–What is the origin of the subtypes? This is important to find a possible matching of scenarios to subtypes.

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