scholarly journals Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells

2012 ◽  
Vol 55 (11) ◽  
pp. 968-973 ◽  
Author(s):  
Mi Li ◽  
LianQing Liu ◽  
Ning Xi ◽  
YueChao Wang ◽  
ZaiLi Dong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Red Blood Cells ◽  
Cancer Cells ◽  
Blood Cells ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Aggressive Cancer ◽  
Atomic Force Microscopy Imaging

scholarly journals Alteration of nanomechanical properties of pancreatic cancer cells through anticancer drug treatment revealed by atomic force microscopy

2021 ◽  
Vol 12 ◽  
pp. 1372-1379
Author(s):  
Xiaoteng Liang ◽  
Shuai Liu ◽  
Xiuchao Wang ◽  
Dan Xia ◽  
Qiang Li
Keyword(s):  
Mechanical Properties ◽  
Pancreatic Cancer ◽  
Atomic Force Microscopy ◽  
Cancer Cells ◽  
Young’S Modulus ◽  
Young's Modulus ◽  
Force Microscopy ◽  
Pancreatic Cancer Cells ◽  
Atomic Force ◽  
Aggressive Cancer

The mechanical properties of cells are key to the regulation of cell activity, and hence to the health level of organisms. Here, the morphology and mechanical properties of normal pancreatic cells (HDPE6-C7) and pancreatic cancer cells (AsPC-1, MIA PaCa-2, BxPC-3) were studied by atomic force microscopy. In addition, the mechanical properties of MIA PaCa-2 after treatment with different concentrations of doxorubicin hydrochloride (DOX) were also investigated. The results show the Young's modulus of normal cells is greater than that of three kinds of cancer cells. The Young's modulus of more aggressive cancer cell AsPC-1 is smaller than that of less aggressive cancer cell BxPC-3. In addition, the Young's modulus of MIA PaCa-2 rises with the increasing of DOX concentration. This study may provide a new strategy of detecting cancer, and evaluate the possible interaction of drugs on cells.

scholarly journals Atomic Force Microscopy Imaging Reveals Structural and Mechanical Properties of Dissociated Hemocyanins by Temperature

2014 ◽  
Vol 106 (2) ◽  
pp. 55a
Author(s):  
Camilo Navarrete ◽  
Javiera Villar ◽  
Yessenia Aguilar ◽  
Ricardo Cabrera ◽  
Nelson P. Barrera
Keyword(s):  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Atomic Force Microscopy Imaging

scholarly journals High-frequency multimodal atomic force microscopy

2014 ◽  
Vol 5 ◽  
pp. 2459-2467 ◽  
Author(s):  
Adrian P Nievergelt ◽  
Jonathan D Adams ◽  
Pascal D Odermatt ◽  
Georg E Fantner
Keyword(s):  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
High Frequency ◽  
High Speed ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Nanoscale Topography ◽  
Atomic Force Microscopy Imaging ◽  
Speed Method

Multifrequency atomic force microscopy imaging has been recently demonstrated as a powerful technique for quickly obtaining information about the mechanical properties of a sample. Combining this development with recent gains in imaging speed through small cantilevers holds the promise of a convenient, high-speed method for obtaining nanoscale topography as well as mechanical properties. Nevertheless, instrument bandwidth limitations on cantilever excitation and readout have restricted the ability of multifrequency techniques to fully benefit from small cantilevers. We present an approach for cantilever excitation and deflection readout with a bandwidth of 20 MHz, enabling multifrequency techniques extended beyond 2 MHz for obtaining materials contrast in liquid and air, as well as soft imaging of delicate biological samples.

scholarly journals Effects of tip-nanotube interactions on atomic force microscopy imaging of carbon nanotubes

Nano Research ◽  
2012 ◽  
Vol 5 (4) ◽  
pp. 235-247 ◽  
Author(s):  
Rouholla Alizadegan ◽  
Albert D. Liao ◽  
Feng Xiong ◽  
Eric Pop ◽  
K. Jimmy Hsia
Keyword(s):  
Carbon Nanotubes ◽  
Atomic Force Microscopy ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Atomic Force Microscopy Imaging

scholarly journals Atomic force microscopy imaging of live mammalian cells

2013 ◽  
Vol 56 (9) ◽  
pp. 811-817 ◽  
Author(s):  
Mi Li ◽  
LianQing Liu ◽  
Ning Xi ◽  
YueChao Wang ◽  
ZaiLi Dong ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Mammalian Cells ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Atomic Force Microscopy Imaging

Atomic Force Microscopy Imaging of Filamentous Aggregates from an N-Terminal Peptide Fragment of Barnase

1993 ◽  
Vol 32 (Part 1, No. 6B) ◽  
pp. 2965-2968 ◽  
Author(s):  
Teiko Shibata-Seki ◽  
Junji Masai ◽  
Kenji Yoshida ◽  
Kazuki Sato ◽  
Hiroshi Yanagawa
Keyword(s):  
Atomic Force Microscopy ◽  
Peptide Fragment ◽  
Microscopy Imaging ◽  
Force Microscopy ◽  
Atomic Force ◽  
Atomic Force Microscopy Imaging
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