Impulsivity and Stressful Life Events Independently Relate to Problematic Substance Use in At-Risk Adolescents

Author(s):  
Margaret R. Bullerjahn ◽  
Nora E. Charles ◽  
Lauren C. Burns ◽  
Christopher T. Barry
2021 ◽  
Author(s):  
Adam C. Alexander ◽  
Joseph J.C. Waring ◽  
Oluwakemi Olurotimi ◽  
Jasmin Kurien ◽  
Bishop Noble ◽  
...  

2016 ◽  
Vol 19 (3) ◽  
pp. 529-542 ◽  
Author(s):  
Whitney P. Witt ◽  
Kara C. Mandell ◽  
Lauren E. Wisk ◽  
Erika R. Cheng ◽  
Debanjana Chatterjee ◽  
...  

2016 ◽  
Vol 26 ◽  
pp. S501 ◽  
Author(s):  
R.M. Gabernet ◽  
M. Tost ◽  
A. Gutiérrez-Zotes ◽  
V. Sánchez-Gistau ◽  
M. Solé ◽  
...  

2016 ◽  
Vol 31 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Mariliis Vaht ◽  
Kariina Laas ◽  
Evelyn Kiive ◽  
Jüri Parik ◽  
Toomas Veidebaum ◽  
...  

Background: The neuregulin 1 gene is a susceptibility gene for substance dependence. A functional polymorphism (SNP8NRG243177/rs6994992; C/T) in the promoter region of the brain-specific type IV neuregulin-1 gene ( NRG1) has been associated with psychiatric disorders (e.g. schizophrenia and bipolar disorder) that often present higher odds of smoking, alcohol and illicit drug use. This study assessed the association of the NRG1 genotype with drug use and possible interaction with stressful life events (SLEs). Methods: The database of the Estonian Children Personality Behaviour and Health Study (beginning in 1998) was used. Cohorts of children initially 9 years old ( n=583; followed up at 15 and 18 years) and 15 years old ( n=593; followed up at 18 and 25 years) provided self-reports on alcohol, tobacco and illicit substance use and SLEs. Psychiatric assessment based on DSM-IV was carried out on the older birth cohort at age 25 to assess the lifetime presence of substance use disorders. NRG1 rs6994992 was genotyped in all participants by TaqMan® Pre-Designed SNP Genotyping Assay on the Applied Biosystems ViiA™ 7 Real-Time PCR System. The minor (T) allele frequency was 0.37. Results: NRG1 rs6994992 C/C homozygotes, especially those who had experienced more SLEs, were more likely to develop alcohol use disorders by young adulthood, were generally more active consumers of tobacco products, and had more likely used illicit drugs. In T allele carriers, SLEs had a negligible effect on substance use. Conclusions: In humans, NRG1 genotype is associated with substance use, and this relationship is moderated by adverse life events, with a gain-of-function allele being protective.


1999 ◽  
Vol 11 (4) ◽  
pp. 823-844 ◽  
Author(s):  
MICHAEL WINDLE ◽  
PATRICK T. DAVIES

This study of over 1,000 adolescents focused on common and distinctive correlates of four subgroups—no problem, depressed only, heavy drinking only, and mixed (depressed and heavy drinking). Correlates were evaluated from the domains of personal dispositions (e.g., temperament), interpersonal relations (e.g., parent and peer), stressful life events, and other problem behaviors (e.g., delinquency, substance use). The no-problem subgroup differed from the other three subgroups in the direction of healthier functioning on almost all measures. The mixed subgroup reported the most pervasive, low levels of functioning, with the highest levels of childhood externalizing problems and stressful life events, the lowest levels of family social support, and high levels of delinquency and substance use. The depressed-only subgroup reported a more internalized pattern characterized by childhood avoidance problems, a difficult temperament (e.g., inflexibility, withdrawal, low task orientation), interpersonal stressors, and poor coping strategies. The heavy-drinking-only subgroup was characterized by higher drinking levels by primary caregivers and lower levels of family cohesion as reported by primary caregivers. The 1-year prospective findings were generally consistent with the concurrent findings in that variables that were associated with transitions toward and away from depression and heavy drinking were associated with specific transitions (e.g., childhood externalizing problems were associated with the transition from no problem to heavy drinking).


Sign in / Sign up

Export Citation Format

Share Document