Effects of Testosterone Supplementation on Body Composition in HIV Patients: A Meta-analysis of Double-blinded Randomized Controlled Trials

Background: Vitamin D deficiency during pregnancy or infancy is associated with adverse growth in children. No systematic review has been conducted to summarize available evidence on the effect of vitamin D supplementation in pregnancy and infancy on growth and body composition in children. Objective: We aim to summarize the available evidence on the effect of vitamin D supplementation in pregnancy and infancy on child growth and body composition. Method: A systematic review and meta-analysis were performed on the effects of vitamin D supplementation during early life on children’s growth and body composition (bone, lean and fat). A literature search of randomized controlled trials (RCTs) was conducted to identify relevant studies on the effects of vitamin D supplementation during pregnancy and infancy on children’s body composition (bone, lean and fat) in PubMed, EMBASE and Cochrane Library from inception to 31 December 2020. A Cochrane Risk Assessment Tool was used for quality assessment. The comparison was vitamin D supplementation vs. placebo or standard care. Random-effects and fixed-effect meta-analyses were conducted. The effects are presented as mean differences (MDs) or risk ratios (RRs) with 95% confidence intervals (CIs). Results: A total of 3960 participants from eleven randomized controlled trials were eligible for inclusion. Vitamin D supplementation during pregnancy was associated with higher triceps skinfold thickness (mm) (MD 0.33, 95% CI, 0.12, 0.54; I2 = 34%) in neonates. Vitamin D supplementation during pregnancy or infancy was associated with significantly increased length for age z-score in infants at 1 year of age (MD 0.29, 95% CI, 0.03, 0.54; I2 = 0%), and was associated with lower body mass index (BMI) (kg/m2) (MD −0.19, 95% CI −0.34, −0.04; I2 = 0%) and body mass index z-score (BMIZ) (MD −0.12, 95% CI −0.21, −0.04; I2 = 0%) in offspring at 3–6 years of age. Vitamin D supplementation during early life was not observed to be associated with children’s bone, lean or fat mass. Conclusion: Vitamin D supplementation during pregnancy or infancy may be associated with reduced adiposity in childhood. Further large clinical trials of the effects of vitamin D supplementation on childhood body composition are warranted.

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Testosterone supplementation and body composition: results from a meta-analysis of randomized controlled trials

Endocrine Abstracts ◽

10.1530/endoabs.41.ep204 ◽

2016 ◽

Author(s):

Giovanni Corona ◽

Vito A Giagulli ◽

Elisa Maseroli ◽

Linda Vignozzi ◽

Antonio Aversa ◽

...

Keyword(s):

Body Composition ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled

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The Protein Recommended Dietary Allowance Is Adequate to Retain Lean Body Mass: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (P08-065-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.p08-065-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Joshua Hudson ◽

Yu Wang ◽

Robert Bergia ◽

Wayne Campbell

Keyword(s):

Systematic Review ◽

Body Composition ◽

Randomized Controlled Trials ◽

Lean Body Mass ◽

Body Mass ◽

Nitrogen Balance ◽

Meta Analysis ◽

Whole Body ◽

Controlled Trials ◽

Randomized Controlled

Abstract Objectives Classic short-term nitrogen balance research estimated that the Recommended Dietary Allowance (RDA) of 0.8 g protein/kg/d would be adequate to maintain whole-body nitrogen balance in 97.5% of the population. However, achieving whole-body nitrogen balance does not necessarily equate with tissue-specific amino acid (nitrogen) needs, for example in skeletal muscle. The objective of this systematic review and meta-analysis was to assess in weight-stable adults the effects of chronically consuming greater than the protein RDA, compared to the RDA, on whole-body composition. Methods Articles published through 2018 were identified with PubMed, Scopus, Cochrane, and CINAHL databases. Five articles with 7 comparisons were identified to be relevant through the databases and through screening previous published reviews. Two researchers independently screened the articles for eligible randomized controlled trials (RCTs) of parallel design that measured changes in body composition after ³6 wk of dietary control. Results There was significant heterogeneity in the effect sizes amongst the comparisons (I2 = 72.8%, χ2 = 22.1, P = 0.001). Consuming greater than the protein RDA did not differentially affect any of the changes in total body mass [0.07 kg (−0.75, 0.88); WMD, (95% CI), Random effects], fat mass [−0.65 kg (−1.33, 0.03)], or lean body mass [0.08 kg (−0.59, 0.75)]. Conclusions These results from controlled feeding RCTs support adequacy of the protein RDA to retain lean body mass and indicate that protein intakes greater than the RDA do not promote morphological changes among weight-stable adults. Funding Sources Purdue University Graduate Lynn Fellowship. No external funding was provided for this review.

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