Prognostic Significance of Pre- and Post-operative Red-Cell Distribution Width in Patients with Gastric Cancer

Abstract Background Platelet distribution width (PDW) and red cell distribution width (RDW) are readily obtainable data, and are reportedly useful as prognostic indicators in some cancers. However, their prognostic significance is unclear in gastric cancer (GC). Methods We enrolled 445 patients with histopathological diagnoses of gastric adenocarcinoma who had undergone curative surgeries. Results According to the optimal cut-off value of PDW and RDW by receiver operating characteristic (ROC) analysis, we divided patients into PDWHigh (≥ 16.75%), PDWLow (< 16.75%), RDWHigh (≥ 14.25%), and RDWLow (< 14.25%) subgroups. Overall survival (OS) was significantly worse in patients with PDWHigh than in those with PDWLow (P = 0.0015), as was disease specific survival (P = 0.043). OS was also significantly worse in patients with RDWHigh than in those with RDWLow (P < 0.0001), as was disease specific survival (P = 0.0002). Multivariate analysis for OS revealed that both PDW and RDW were independent prognostic indicators. Patients were then given PDW-RDW score by adding points for their different subgroups (1 point each for PDWHigh and RDWHigh; 0 points for PDWLow and RDWLow). OS significantly differed by PDW-RDW score (P < 0.0001), as did disease specific survival (P = 0.0005). In multivariate analysis for OS, PDW-RDW score was found to be an independent prognostic indicator. Conclusions The prognosis of GC patients can be precisely predictable by using both PDW and RDW.

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Prognostic significance of red cell distribution width in idiopathic pulmonary fibrosis and combined pulmonary fibrosis emphysema

Medical Principles and Practice ◽

10.1159/000511106 ◽

2020 ◽

Author(s):

Aslıhan Gürün Kaya ◽

Berna Akıncı Ozyurek ◽

Tuğçe Şahin Özdemirel ◽

Miraç Öz ◽

Yurdanur Erdoğan

Keyword(s):

Idiopathic Pulmonary Fibrosis ◽

Pulmonary Fibrosis ◽

Prognostic Significance ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width

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Prognostic significance of red cell distribution width and other red cell parameters in patients with chronic heart failure during two years of follow-up

Kardiologia Polska ◽

10.5603/kp.a2016.0004 ◽

2016 ◽

pp. 657-664 ◽

Cited By ~ 1

Author(s):

Łukasz Wołowiec ◽

Daniel Rogowicz ◽

Joanna Banach ◽

Katarzyna Buszko ◽

Agnieszka Surowiec ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Prognostic Significance ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Cell Parameters

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The Ratio of the Hemoglobin to Red Cell Distribution Width Combined with the Ratio of Platelets to Lymphocytes Can Predict the Survival of Patients with Gastric Cancer Liver Metastasis

BioMed Research International ◽

10.1155/2021/8729869 ◽

2021 ◽

Vol 2021 ◽

pp. 1-12

Author(s):

Zhao Zhai ◽

Jialiang Gao ◽

Ziyu Zhu ◽

Xiliang Cong ◽

Shenghan Lou ◽

...

Keyword(s):

Gastric Cancer ◽

Liver Metastasis ◽

Liver Metastases ◽

Scoring System ◽

Prognostic Nutritional Index ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Neutrophil Lymphocyte Ratio

Background. Hemoglobin/red cell distribution width (HR) and platelet/lymphocyte (PLR) ratios are considered effective prognostic markers in various cancers. We have proposed a new prognostic parameter: HR+PLR. The aim of this study is to explore the prognostic value of the HR+PLR scoring system in patients with gastric cancer liver metastasis. Methods. This study retrospectively analyzed the clinical data of 306 patients with gastric cancer liver metastases admitted to our hospital from 2007 to 2014. According to the size of HR value and PLR value, we will divide the patients into three groups, namely, HR+PLR: (1) 0 points: HR > 1.02 and PLR < 128 ; (2) 1 point: HR > 1.02 and PLR > 128 and HR < 1.02 and PLR < 128 ; and (3) 2 points: HR < 1.02 and PLR > 128 . Results. The HR+PLR score was statistically different from age ( P = 0.049 ), T stage ( P < 0.001 ), N stage ( P = 0.017 ), number of liver metastases ( P = 0.018 ), gastrectomy ( P < 0.001 ), hepatectomy ( P = 0.001 ), peritoneal metastasis ( P = 0.012 ), prognostic nutritional index (PNI) ( P = 0.028 ), and neutrophil/lymphocyte ratio (NLR) ( P = 0.045 ). The HR+PLR scoring system has a higher area under the ROC curve (AUC value) than PNI, PLR, HR, and PLR ( AUC = 0.798 , P < 0.001 ). In multivariate analysis, gastrectomy ( P = 0.001 ), hepatectomy ( P < 0.001 ), chemotherapy ( P = 0.014 ), and HR+PLR score ( P < 0.001 ) were considered independent prognostic factors. Conclusion. For patients with gastric cancer liver metastasis, the HR+PLR score is a simple, reliable, and economic prognostic marker.

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Prognostic significance of red cell distribution width and its relation to increased pulmonary pressure and inflammation in acute heart failure

Cardiology Journal ◽

10.5603/cj.a2018.0103 ◽

2020 ◽

Vol 27 (4) ◽

pp. 394-403 ◽

Cited By ~ 1

Author(s):

Ryszard Targoński ◽

Janusz Sadowski ◽

Magdalena Starek-Stelmaszczyk ◽

Radosław Targoński ◽

Andrzej Rynkiewicz

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Prognostic Significance ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Pulmonary Pressure

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The importance of red cell distribution width on gastric cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e15502 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e15502-e15502

Author(s):

Dilek Erdem ◽

Emre Erdem ◽

Yasemin Turgut Kurt ◽

Turkan Topcu ◽

Turgut Kacan ◽

...

Keyword(s):

Gastric Cancer ◽

Healthy Subjects ◽

Neutrophil To Lymphocyte Ratio ◽

Red Cell Distribution Width ◽

Chronic Obstructive ◽

Red Cell ◽

Cell Distribution ◽

Platelet To Lymphocyte Ratio ◽

Distribution Width ◽

Lymphocyte Ratio

e15502 Background: Red cell distribution width (RDW) is an elevated marker in several cancers like breast, colon, prostate and pancreatic cancer at the time of diagnosis. Gastric cancer (GC) is the fifth most common cancer and also third leading cause of cancer deaths.We aimed to determine whether RDW values differ between gastric cancer and healthy subjects, as well as to evaluate association between RDW and other factors. Also, we examined other two important inflammatory markers in GC patients: neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) Methods: This retrospective study included 68 gastric cancer patients and 42 age and sex matched healthy controls. The exclusion criteria involved cardiac disease, chronic obstructive lung disease, thromboembolism, chronic renal failure, hepatic disorders, hypertension, acute and chronic infections, stroke, hematologic disease and other accompanying cancer. Blood samples were retrospectively obtained from computerized patient database. Results: Among 110 subjects; RDW, NLR and PLR were significantly higher in GC patients when compared to healthy subjects (RDW: 44,9 vs 41,4 p < 0.0001, NLR: 3,40 vs 1,90 p < 0.0001, PLR: 245,9 vs 131,1 p = 0.007). There was no statistically significant association between these markers (RDW, NLR and PLR) and stage, histopathological subgroups and metastasis stage at the time of diagnosis. Conclusions: Elevated RDW is a simple, cheap and readily available marker and may be useful in gastric cancer at the time of diagnosis. Also, NLR and PLR can accompany RDW in the assessment of gastric cancer. Key words: gastric, red cell distribution width, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, cancer

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Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer

Gastroenterology Research and Practice ◽

10.1155/2018/8042838 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Danyang Zhou ◽

Ying Wu ◽

Zhenyu Lin ◽

Liangliang Shi ◽

Lei Zhao ◽

...

Keyword(s):

Gastric Cancer ◽

Progression Free Survival ◽

Tumor Location ◽

Neutrophil To Lymphocyte Ratio ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Prognostic System ◽

Lymphocyte Ratio

Aims. Gastric cancer (GC) is often diagnosed at an advanced stage; inexpensive and valid biomarkers for GC are still unavailable. We aimed to evaluate the prognosis of the combination of pretreatment red cell distribution width (RDW) and neutrophil-to-lymphocyte ratio (NLR) in patients with GC. Methods. A retrospective analysis from 103 GC patients who were diagnosed at our institution from 2012 to 2016 was performed. Both pretreatment RDW and NLR were calculated based on the recommended cutoff values of 13.4% and 2.755, respectively. Combined values of RDW and NLR (RDW + NLR) stratified patients into a score of 0 (RDW ≤ 13.4% and NLR ≤ 2.755), a score of 1 (RDW > 13.4% or NLR > 2.755), and a score of 2 (RDW > 13.4% and NLR > 2.755). Prognostic significances for overall survival (OS) and progression-free survival (PFS) were assessed. Results. Pretreatment RDW + NLR was a significantly independent prognostic factor for OS and PFS. Moreover, high RDW + NLR was strongly related to age, tumor location, TNM stage, CA125, and CA199. In a subgroup analysis for patients with advanced gastric cancer (AGC), we observed that the level of RDW + NLR was markedly associated with OS and PFS. Conclusion. Pretreatment RDW + NLR is a simple, inexpensive, and valid prognostic system to predict the survival in patients with GC, especially AGC.

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