scholarly journals REMAXINT: a two-mode clustering-based method for statistical inference on two-way interaction

2021 ◽  
Author(s):  
Zaheer Ahmed ◽  
Alberto Cassese ◽  
Gerard van Breukelen ◽  
Jan Schepers
Keyword(s):  
Null Hypothesis ◽  
Type I Error ◽  
Type I ◽  
The Novel ◽  
Simulation Studies ◽  
Test Statistic ◽  
Clustering Model ◽  
Novel Method ◽  
Main Effects ◽  
Empirical Case Studies

AbstractWe present a novel method, REMAXINT, that captures the gist of two-way interaction in row by column (i.e., two-mode) data, with one observation per cell. REMAXINT is a probabilistic two-mode clustering model that yields two-mode partitions with maximal interaction between row and column clusters. For estimation of the parameters of REMAXINT, we maximize a conditional classification likelihood in which the random row (or column) main effects are conditioned out. For testing the null hypothesis of no interaction between row and column clusters, we propose a $$max-F$$ m a x - F test statistic and discuss its properties. We develop a Monte Carlo approach to obtain its sampling distribution under the null hypothesis. We evaluate the performance of the method through simulation studies. Specifically, for selected values of data size and (true) numbers of clusters, we obtain critical values of the $$max-F$$ m a x - F statistic, determine empirical Type I error rate of the proposed inferential procedure and study its power to reject the null hypothesis. Next, we show that the novel method is useful in a variety of applications by presenting two empirical case studies and end with some concluding remarks.

scholarly journals More on the Supremum Statistic to Test Multivariate Skew-Normality

Computation ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 126
Author(s):  
Timothy Opheim ◽  
Anuradha Roy
Keyword(s):  
Monte Carlo Simulation ◽  
Monte Carlo ◽  
Type I Error ◽  
Relevant Information ◽  
Type I ◽  
Simulation Studies ◽  
Test Statistic ◽  
Nominal Significance ◽  
Significance Levels ◽  
Empirical Size

This review is about verifying and generalizing the supremum test statistic developed by Balakrishnan et al. Exhaustive simulation studies are conducted for various dimensions to determine the effect, in terms of empirical size, of the supremum test statistic developed by Balakrishnan et al. to test multivariate skew-normality. Monte Carlo simulation studies indicate that the Type-I error of the supremum test can be controlled reasonably well for various dimensions for given nominal significance levels 0.05 and 0.01. Cut-off values are provided for the number of samples required to attain the nominal significance levels 0.05 and 0.01. Some new and relevant information of the supremum test statistic are reported here.

One-Sided Nonparametric Tests for Ordinal Data

2005 ◽  
Vol 101 (2) ◽  
pp. 510-514 ◽  
Author(s):  
Markus Neuhäuser
Keyword(s):  
Ordinal Data ◽  
Type I Error ◽  
Nonparametric Test ◽  
Psychological Research ◽  
Nonparametric Tests ◽  
Wilcoxon Test ◽  
Type I ◽  
The Novel ◽  
Test Statistic ◽  
Wilcoxon Rank Sum Test

Baumgartner, Weiß, and Schindler (1998) introduced a novel nonparametric test for the two-sample comparison that is superior to commonly used tests such as the Wilcoxon rank-sum test. A modification of the novel test statistic can be used for one-sided comparisons based on ordinal data. Such comparisons frequently occur in psychological research, and the Wilcoxon test is often recommended for their analysis. Here, the two tests were compared in a simulation study. According to this study the tests have a similar type I error rate, but the modified Baumgartner-Weiß-Schindler test is more powerful than the Wilcoxon test.

scholarly journals Testing for treatment effect in covariate-adaptive randomized trials with generalized linear models and omitted covariates

2021 ◽  
pp. 096228022110082
Author(s):  
Yang Li ◽  
Wei Ma ◽  
Yichen Qin ◽  
Feifang Hu
Keyword(s):  
Generalized Linear Models ◽  
Treatment Effect ◽  
Linear Models ◽  
Type I Error ◽  
Type I ◽  
Test Statistic ◽  
Asymptotic Results ◽  
Adaptive Randomization ◽  
Adjustment Method ◽  
Inflated Type

Concerns have been expressed over the validity of statistical inference under covariate-adaptive randomization despite the extensive use in clinical trials. In the literature, the inferential properties under covariate-adaptive randomization have been mainly studied for continuous responses; in particular, it is well known that the usual two-sample t-test for treatment effect is typically conservative. This phenomenon of invalid tests has also been found for generalized linear models without adjusting for the covariates and are sometimes more worrisome due to inflated Type I error. The purpose of this study is to examine the unadjusted test for treatment effect under generalized linear models and covariate-adaptive randomization. For a large class of covariate-adaptive randomization methods, we obtain the asymptotic distribution of the test statistic under the null hypothesis and derive the conditions under which the test is conservative, valid, or anti-conservative. Several commonly used generalized linear models, such as logistic regression and Poisson regression, are discussed in detail. An adjustment method is also proposed to achieve a valid size based on the asymptotic results. Numerical studies confirm the theoretical findings and demonstrate the effectiveness of the proposed adjustment method.

scholarly journals Considering Both Statistical and Clinical Significance

2016 ◽  
Vol 5 (5) ◽  
pp. 16 ◽  
Author(s):  
Guolong Zhao
Keyword(s):  
Clinical Significance ◽  
Null Hypothesis ◽  
Type I Error ◽  
Statistical Significance ◽  
Error Rates ◽  
Type I ◽  
Data Set ◽  
Type I Error Rates ◽  
Empirical Coverage ◽  
Superiority Trials

To evaluate a drug, statistical significance alone is insufficient and clinical significance is also necessary. This paper explains how to analyze clinical data with considering both statistical and clinical significance. The analysis is practiced by combining a confidence interval under null hypothesis with that under non-null hypothesis. The combination conveys one of the four possible results: (i) both significant, (ii) only significant in the former, (iii) only significant in the latter or (iv) neither significant. The four results constitute a quadripartite procedure. Corresponding tests are mentioned for describing Type I error rates and power. The empirical coverage is exhibited by Monte Carlo simulations. In superiority trials, the four results are interpreted as clinical superiority, statistical superiority, non-superiority and indeterminate respectively. The interpretation is opposite in inferiority trials. The combination poses a deflated Type I error rate, a decreased power and an increased sample size. The four results may helpful for a meticulous evaluation of drugs. Of these, non-superiority is another profile of equivalence and so it can also be used to interpret equivalence. This approach may prepare a convenience for interpreting discordant cases. Nevertheless, a larger data set is usually needed. An example is taken from a real trial in naturally acquired influenza.

scholarly journals Model Error in Covariance Structure Models

Methodology ◽  
2008 ◽  
Vol 4 (4) ◽  
pp. 159-167 ◽  
Author(s):  
Donna L. Coffman
Keyword(s):  
Error Rate ◽  
Null Hypothesis ◽  
Type I Error ◽  
Sampling Error ◽  
Model Error ◽  
Type I ◽  
Empirical Power ◽  
Parameter Drift ◽  
Type I Error Rate ◽  
Close Fit

This study investigated the degree to which violation of the parameter drift assumption affects the Type I error rate for the test of close fit and the power analysis procedures proposed by MacCallum et al. (1996) for both the test of close fit and the test of exact fit. The parameter drift assumption states that as sample size increases both sampling error and model error (i.e., the degree to which the model is an approximation in the population) decrease. Model error was introduced using a procedure proposed by Cudeck and Browne (1992). The empirical power for both the test of close fit, in which the null hypothesis specifies that the root mean square error of approximation (RMSEA) ≤ 0.05, and the test of exact fit, in which the null hypothesis specifies that RMSEA = 0, is compared with the theoretical power computed using the MacCallum et al. (1996) procedure. The empirical power and the theoretical power for both the test of close fit and the test of exact fit are nearly identical under violations of the assumption. The results also indicated that the test of close fit maintains the nominal Type I error rate under violations of the assumption.

scholarly journals Effective Analysis of Interactive Effects with Non-Normal Data Using the Aligned Rank Transform, ARTool and SAS® University Edition

Horticulturae ◽  
2019 ◽  
Vol 5 (3) ◽  
pp. 57 ◽  
Author(s):  
Edward Durner
Keyword(s):  
Type I Error ◽  
Interactive Effects ◽  
Type I ◽  
Rank Transform ◽  
Parametric Testing ◽  
Aligned Rank ◽  
Departure From Normality ◽  
Main Effects ◽  
Horticultural Research ◽  
Non Parametric

Most statistical techniques commonly used in horticultural research are parametric tests that are valid only for normal data with homogeneous variances. While parametric tests are robust when the data ‘slightly’ deviate from normality, a significant departure from normality leads to reduced power and the probability of a type I error increases. Transformations often used to normalize non-normal data can be time consuming, cumbersome and confusing and common non-parametric tests are not appropriate for evaluating interactive effects common in horticultural research. The aligned rank transformation allows non-parametric testing for interactions and main effects using standard ANOVA techniques. This has not been widely adapted due to its rigorous mathematical nature, however, a downloadable (ARTool) is now available, which performs the math needed for the transformation. This study provides step-by-step instructions for integrating ARTool with the free edition of SAS (SAS University Edition) in an easily employed method for testing normality, transforming data with aligned ranks, and analysing data using standard ANOVAs.

scholarly journals A novel gene-set association test based on variance-gamma distribution

2018 ◽  
Vol 28 (9) ◽  
pp. 2868-2875
Author(s):  
Zhongxue Chen ◽  
Qingzhong Liu ◽  
Kai Wang
Keyword(s):  
Gamma Distribution ◽  
Type I Error ◽  
Null Distribution ◽  
Real Data ◽  
Association Test ◽  
P Value ◽  
Type I ◽  
Test Statistic ◽  
Data Set ◽  
Variance Gamma

Several gene- or set-based association tests have been proposed recently in the literature. Powerful statistical approaches are still highly desirable in this area. In this paper we propose a novel statistical association test, which uses information of the burden component and its complement from the genotypes. This new test statistic has a simple null distribution, which is a special and simplified variance-gamma distribution, and its p-value can be easily calculated. Through a comprehensive simulation study, we show that the new test can control type I error rate and has superior detecting power compared with some popular existing methods. We also apply the new approach to a real data set; the results demonstrate that this test is promising.

When Studies are in Error: Basic Statistical Vocabulary Needed to Understand Clinical Studies

1996 ◽  
Vol 1 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Martin A. Weinstock
Keyword(s):  
Null Hypothesis ◽  
Statistical Power ◽  
Critical Appraisal ◽  
Type I Error ◽  
Statistical Significance ◽  
P Value ◽  
Type I ◽  
Type Ii ◽  
Type Ii Error ◽  
Error Type

Background: Accurate understanding of certain basic statistical terms and principles is key to critical appraisal of published literature. Objective: This review describes type I error, type II error, null hypothesis, p value, statistical significance, a, two-tailed and one-tailed tests, effect size, alternate hypothesis, statistical power, β, publication bias, confidence interval, standard error, and standard deviation, while including examples from reports of dermatologic studies. Conclusion: The application of the results of published studies to individual patients should be informed by an understanding of certain basic statistical concepts.

Parametric Alternatives to the Analysis of Variance

1982 ◽  
Vol 7 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Jennifer J. Clinch ◽  
H. J. Keselman
Keyword(s):  
Monte Carlo ◽  
Analysis Of Variance ◽  
Monte Carlo Methods ◽  
Type I Error ◽  
Type I ◽  
Test Statistic ◽  
F Test ◽  
Assumption Violations ◽  
Mean Equality

The ANOVA, Welch, and Brown and Forsyth tests for mean equality were compared using Monte Carlo methods. The tests’ rates of Type I error and power were examined when populations were non-normal, variances were heterogeneous, and group sizes were unequal. The ANOVA F test was most affected by the assumption violations. The test proposed by Brown and Forsyth appeared, on the average, to be the “best” test statistic for testing an omnibus hypothesis of mean equality.

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