Linggui Zhugan Decoction (苓桂术甘汤) Inhibits Ventricular Remodeling after Acute Myocardial Infarction in Rats by Suppressing TGF-β1/Smad Signaling Pathway

2019 ◽  
Vol 26 (5) ◽  
pp. 345-352
Author(s):  
Liang Wang ◽  
Hui Shi ◽  
Jin-ling Huang ◽  
Shan Xu ◽  
Pei-pei Liu
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Signaling Pathway ◽  
Ventricular Remodeling ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Linggui Zhugan Decoction ◽  
Tgf Β1

scholarly journals Simvastatin ameliorates ventricular remodeling via the TGF-β1 signaling pathway in rats following myocardial infarction

2016 ◽  
Vol 13 (6) ◽  
pp. 5093-5101 ◽  
Author(s):  
XIANGBIN XIAO ◽  
GUANGLEI CHANG ◽  
JIAN LIU ◽  
GUANGYUN SUN ◽  
LI LIU ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Signaling Pathway ◽  
Ventricular Remodeling ◽  
Tgf Β1

TSG-6 Inhibits the Growth of Keloid Fibroblasts Via Mediating the TGF-β1/Smad Signaling Pathway

2020 ◽  
Vol 34 (9) ◽  
pp. 947-956
Author(s):  
Xin-Yi Li ◽  
Xiao-Juan Weng ◽  
Xiao-Jing Li ◽  
Xiao-Yu Tian
Keyword(s):  
Signaling Pathway ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1 ◽  
Keloid Fibroblasts

scholarly journals KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner

2019 ◽  
Vol 294 (21) ◽  
pp. 8361-8370 ◽  
Author(s):  
Yi Peng ◽  
Song Wu ◽  
Qiyu Tang ◽  
Shuaihua Li ◽  
Cheng Peng
Keyword(s):  
Signaling Pathway ◽  
Wound Contraction ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

scholarly journals Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κB-TGF-β1/Smad Signaling Pathway

2020 ◽  
Vol 21 (2) ◽  
pp. 402 ◽  
Author(s):  
Yi Quan ◽  
Woong Park ◽  
Jixiu Jin ◽  
Won Kim ◽  
Sung Kwang Park ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Mitochondrial Dynamics ◽  
Unilateral Ureteral Obstruction ◽  
Sirtuin 3 ◽  
Smad Signaling ◽  
Renal Tubulointerstitial Fibrosis ◽  
Smad Signaling Pathway ◽  
Tgf Β1

Renal fibrosis is a common feature of all progressive chronic kidney diseases. Sirtuin 3 (SIRT3) is one of the mitochondrial sirtuins, and plays a role in the regulation of mitochondrial biogenesis, oxidative stress, fatty acid metabolism, and aging. Recently, honokiol (HKL), as a pharmaceutical SIRT3 activator, has been observed to have a protective effect against pressure overload-induced cardiac hypertrophy by increasing SIRT3 activity. In this study, we investigated whether HKL, as a SIRT3 activator, also has protective effects against unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the nuclear factor-κB (NF-κB)/transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. We found that HKL decreased the UUO-induced increase in tubular injury and extracellular matrix (ECM) deposition in mice. HKL also decreased myofibroblast activation and proliferation in UUO kidneys and NRK-49F cells. Finally, we showed that HKL treatment decreased UUO-induced mitochondrial fission and promoted mitochondrial fusion through SIRT3-dependent effects. In conclusion, activation of SIRT3 via HKL treatment might have beneficial effects on UUO-induced renal fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the NF-κB/TGF-β1/Smad signaling pathway.

Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor-β/Smad Signaling Pathway

Pharmacology ◽  
2019 ◽  
Vol 104 (1-2) ◽  
pp. 81-89 ◽  
Author(s):  
Jing Liu ◽  
Tan Deng ◽  
Yaxin Wang ◽  
Mengmeng Zhang ◽  
Guannan Zhu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Collagen I ◽  
Smad Pathway ◽  
Smad Signaling ◽  
Intestinal Fibrosis ◽  
Smad Signaling Pathway ◽  
Tgf Β1

Background: Intestinal fibrosis is the major complication of Crohn’s disease (CD). There are no other good treatments for CD except surgery and remains a refractory disease. Calycosin (CA), the active component of astragalus membranaceus, has been reported the potential effect on lung fibrosis and renal fibrosis. In this study, we aim to explore the effect of CA on intestinal fibrosis in vitro and the possible signal pathway. Methods: The antifibrotic effect of CA is investigated in human intestinal fibroblasts (CCD-18Co) cells induced by transforming growth factor-β1 (TGF-β1). MTT method was used to screen the concentration of CA. Real-time polymerase chain reaction and western blot analysis were used to evaluate the expression of α-smooth muscle actin (α-SMA), collagen I, and TGF-β/Smad pathway. Results: The results showed that the concentration of CA was 12.5, 25, 50 μmol/L. CA could inhibit the expression of α-SMA and collagen I. In addition, CA regulated the expression of TGF-β/Smad signaling pathway. Conclusion: This study demonstrated that CA could inhibit the activation of CCD-18Co cells and reduce the expression of extracellular matrix. Our study highlighted that CA-inhibited TGF-β/Smad pathway through inhibiting the expression of p-Smad2, p-Smad3, Smad4, and TGF-β1 and raised the Smad7 expression. Therefore, CA might inhibit intestinal fibrosis by inhibiting the TGF-β/Smad pathway.

scholarly journals The polysaccharides from Grifola frondosa attenuate CCl4-induced hepatic fibrosis in rats via the TGF-β/Smad signaling pathway

RSC Advances ◽  
2019 ◽  
Vol 9 (58) ◽  
pp. 33684-33692 ◽  
Author(s):  
Chao Li ◽  
Meng Meng ◽  
Mingzhu Guo ◽  
Mengyang Wang ◽  
Aining Ju ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Hepatic Fibrosis ◽  
Grifola Frondosa ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

The TGF-β1/Smad signaling pathway has been linked to hepatic fibrosis.

FoxP3 in papillary thyroid carcinoma induces NIS repression through activation of the TGF-β1/Smad signaling pathway

Tumor Biology ◽  
2015 ◽  
Vol 37 (1) ◽  
pp. 989-998 ◽  
Author(s):  
Siyuan Ma ◽  
Qingzhu Wang ◽  
Xiaojun Ma ◽  
Lina Wu ◽  
Feng Guo ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Signaling Pathway ◽  
Papillary Thyroid ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1
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