scholarly journals Putative invasive pulmonary aspergillosis in apparently immunocompetent patients within medical wards and intensive care units

2021 ◽  
Author(s):  
Babatunde Edun ◽  
Mark Alan Tidswell
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Medical Wards ◽  
Immunocompetent Patients

scholarly journals Putative invasive pulmonary aspergillosis within medical wards and intensive care units: a 4-year retrospective, observational, single-centre study

2021 ◽  
Author(s):  
Silvia Corcione ◽  
Tommaso Lupia ◽  
Stefania Raviolo ◽  
Giorgia Montrucchio ◽  
Alice Trentalange ◽  
...  
Keyword(s):  
Septic Shock ◽  
Intensive Care ◽  
Intensive Care Units ◽  
Hospital Admissions ◽  
Invasive Pulmonary Aspergillosis ◽  
Positive Culture ◽  
Lower Airway ◽  
Organ Support ◽  
Pulmonary Aspergillosis ◽  
Medical Wards

AbstractBlot and colleagues have proposed putative invasive pulmonary aspergillosis (PIPA) definitions for troublesome diagnosis in suspected patients outside the classical criteria of immunosuppression. We retrospectively included in the study all admitted patients with an Aspergillus spp. positive culture within lower airway samples. Overall, Aspergillus spp. positivity in respiratory samples was 0.97 every 1000 hospital admissions (HA): 4.94 and 0.28/1000/HA, respectively, in intensive care units (ICUs) and medical wards (MW). 66.6% fulfilled PIPA criteria, and 33.4% were defined as colonized. 69.2% of PIPA diagnosis occurred in the ICU. Antifungal therapy was appropriate in 88.5% of subjects with PIPA and 37.5% of colonized, confirming the comparison between deads and lives. Patients with PIPA in the ICUs had more frequent COPD, sepsis or septic shock, acute kidney injury (AKI), needed more surgery, mechanical ventilation (MV), vasopressors, hemodialysis, blood or platelets transfusions. PIPA in MW had associated with a history of smoking, interstitial lung disease and inhaled steroid therapy. Overall mortality within 21 days was 50%: 54.2% in ICU, 36,8% in MW. Factors associated with death were length of hospitalization, influenza, pneumonia, liver transplant, AKI, ARDS, sepsis and septic shock. PIPA in the ICU had higher disease severity and needed more organ support than MW cases, despite that cases of PIPA in MW are emerging with trends difficult to demonstrate given the problematic diagnosis.

Invasive pulmonary aspergillosis in intensive care units: is it a real problem?

2010 ◽  
Vol 74 (2) ◽  
pp. 186-187 ◽  
Author(s):  
M. Bassetti ◽  
M. Mikulska ◽  
E. Repetto ◽  
C. Bernardini ◽  
O. Soro ◽  
...  
Keyword(s):  
Intensive Care ◽  
Intensive Care Units ◽  
Invasive Pulmonary Aspergillosis ◽  
Real Problem ◽  
Pulmonary Aspergillosis

scholarly journals A novel diagnosis scoring model to predict invasive pulmonary aspergillosis in the intensive care unit

2019 ◽  
Vol 40 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Anna Rozaliyani ◽  
Rudyanto Sedono ◽  
Anwar Jusuf ◽  
Cleopas Rumende ◽  
Wahju Aniwidyaningsih ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Scoring Model

Invasive pulmonary aspergillosis in immunocompetent patients acquired during renovation in a chest institute

2017 ◽  
Author(s):  
Kshitij Agarwal ◽  
Aradhana Masih ◽  
Mujeeb ur Rahman ◽  
SN Gaur ◽  
Ferry Hagen ◽  
...  
Keyword(s):  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Immunocompetent Patients

Invasive Pulmonary Aspergillosis in Critically Ill Apparently Immunocompetent Patients

2016 ◽  
Vol 23 (4) ◽  
pp. 184-187
Author(s):  
Abdul Rishi ◽  
Imran Sethi ◽  
Michael Jesinger ◽  
Yazen Beddawi ◽  
Scott Morehead ◽  
...  
Keyword(s):  
Critically Ill ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Immunocompetent Patients

scholarly journals Invasive pulmonary aspergillosis in a COVID-19 recovered patient: unravelling an infective sequalae of the SARS-CoV-2 virus

2021 ◽  
Vol 91 (2) ◽  
Author(s):  
Benhur Joel Shadrach ◽  
Rishabh Goel ◽  
Kunal Deokar ◽  
Anukool Jain
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Emergency Room ◽  
Lung Disease ◽  
Invasive Pulmonary Aspergillosis ◽  
Morbidly Obese ◽  
Pulmonary Aspergillosis ◽  
The Past

Dear Editor, A 55-year-female, house wife, non-smoker, morbidly obese (BMI>35) with no other co-morbidities or pre-existing lung disease presented to the emergency room with complaints of highgrade fever, cough with minimal sputum, progressive breathlessness, streaky haemoptysis, and anorexia for the past 5 days. She was admitted in intensive care unit (ICU) for severe COVID-19 pneumonia three months back and had successfully recovered after 24 days of hospitalization....

Invasive Pulmonary Aspergillosis in Patients With Severe Fever With Thrombocytopenia Syndrome

2019 ◽  
Author(s):  
Seongman Bae ◽  
Hye Jeon Hwang ◽  
Mi Young Kim ◽  
Min Jae Kim ◽  
Yong Pil Chong ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Antifungal Therapy ◽  
Invasive Pulmonary Aspergillosis ◽  
Pulmonary Aspergillosis ◽  
Severe Fever

Abstract Sixteen of 45 patients with severe fever with thrombocytopenia (36%) were admitted to an intensive care unit; 9 (56%) developed invasive pulmonary aspergillosis (IPA) within a median of 8 days (range, 2–11). Mortality was higher in the IPA vs non-IPA patients and in those without vs with antifungal therapy.

scholarly journals Invasive pulmonary aspergillosis in immunocompetent patients hospitalised with influenza A-related pneumonia: a multicenter retrospective study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Liang Chen ◽  
Xiudi Han ◽  
Yanli Li ◽  
Chunxiao Zhang ◽  
Xiqian Xing
Keyword(s):  
Risk Factors ◽  
Influenza A ◽  
Invasive Pulmonary Aspergillosis ◽  
Neuraminidase Inhibitor ◽  
Teaching Hospitals ◽  
Multivariate Logistic Regression Model ◽  
Pulmonary Aspergillosis ◽  
Hospitalised Patients ◽  
Increased Risk ◽  
Immunocompetent Patients

Abstract Background Increasing cases of pulmonary aspergillosis (IPA) in immunocompetent patients with severe influenza have been reported. Howevere, the risk factors for occurence and death are largely unknown. Methods Data of hospitalised patients with influenza A-related pneumonia (FluA-p) obtained from five teaching hospitals from 2031 to 2018, were reviewed. Univariate and multivariate logistical regression analyses were performed to determine the risk factors involved in the acquisition and 60-day mortality in IPA patients. Results Of the 693 FluA-p patients included in the study, 3.0% (21/693) were IPA patients with a 60-day mortality of 42.9% (9/21). Adjusted for confounders, a Cox proportional hazard model showed that IPA was associated with increased risk for 60-day mortality [hazard ratio (HR) 4.336, 95% confidence interval (CI) 1.191–15.784, p = 0.026] in FluA-p patients. A multivariate logistic regression model confirmed that age (odd ratio (OR) 1.147, 95% CI 1.048–1.225, p = 0.003), systemic corticosteroids use before IPA diagnosis (OR 33.773, 95% CI 5.681–76.764, p <  0.001), leukocytes > 10 × 109/L (OR 1.988, 95% CI 1.028–6.454, p = 0.029) and lymphocytes < 0.8 × 109/L on admission (OR 34.813, 95% CI 1.676–73.006, p = 0.022), were related with the acquisition of IPA. Early neuraminidase inhibitor use (OR 0.290, 95% CI 0.002–0.584, p = 0.021) was associated with a decreased risk for a 60-day mortality in IPA patients. Conclusions Our results showed that IPA worsen the clinical outcomes of FluA-p patients. The risk factors for the acquisition and death were helpful for the clinicians in preventing and treating IPA.

Viral, Fungal, and Atypical Infections

2017 ◽  
Author(s):  
Daniel Caroff ◽  
Chanu Rhee
Keyword(s):  
Respiratory Tract Infections ◽  
Clinical Presentation ◽  
Invasive Pulmonary Aspergillosis ◽  
Infectious Agents ◽  
Pulmonary Aspergillosis ◽  
Clinical Syndromes ◽  
Immunosuppressed Patients ◽  
Candida Infections ◽  
Tract Infections ◽  
Immunocompetent Patients

Viral, fungal, and “atypical” bacterial pathogens are important causes of infections in critically ill patients. Many of these pathogens predominantly cause disease in immunosuppressed patients, but immunocompetent patients can also face serious illness or death. Understanding the risk factors and clinical syndromes caused by these pathogens is necessary to quickly identify patients who may need specialized diagnostics and treatment and is an essential component of training for any provider who practices in the intensive care unit. In this review, we discuss the most relevant aspects of clinical presentation, epidemiology, diagnosis, and management of these infectious agents, with a particular focus on respiratory tract infections. New advances in the diagnosis and treatment of influenza, invasive Candida infections, aspergillosis, and Legionella are highlighted. This review contains 3 figures, 5 tables, and 94 references. Key words: Candida, influenza, invasive pulmonary aspergillosis, Legionella pneumophilia, viral pneumonia

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