Celastrus orbiculatus Thunb. Decreases Athero-Susceptibility in Lipoproteins and the Aorta of Guinea Pigs Fed High Fat Diet

Lipids ◽  
2013 ◽  
Vol 48 (6) ◽  
pp. 619-631 ◽  
Author(s):  
Ying Zhang ◽  
Yanhong Si ◽  
Shutong Yao ◽  
Nana Yang ◽  
Guohua Song ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Guinea Pigs ◽  
Celastrus Orbiculatus ◽  
High Fat

scholarly journals The development of nonalcoholic steatohepatitis is subjected to breeder dependent variation in guinea pigs

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
D. H. Ipsen ◽  
R. H. Agerskov ◽  
J. H. Klaebel ◽  
J. Lykkesfeldt ◽  
Pernille Tveden-Nyborg
Keyword(s):  
Aspartate Aminotransferase ◽  
High Fat Diet ◽  
Guinea Pigs ◽  
Liver Cholesterol ◽  
Disease Development ◽  
High Fat ◽  
Preclinical Research ◽  
Hepatic Expression ◽  
Reproducibility Study ◽  
The Impact

AbstractVariability in disease development due to differences in strains and breeders constitutes a substantial challenge in preclinical research. However, the impact of the breeder on non-alcoholic steatohepatitis (NASH) is not yet fully elucidated. This retrospective study investigates NASH development in guinea pigs from Charles River or Envigo fed a high fat diet (20% fat, 15% sucrose, 0.35% cholesterol) for 16 or 24/25 weeks. Charles River animals displayed more severe NASH, with higher steatosis (p < 0.05 at week 16), inflammation (p < 0.05 at both week), fibrosis (p < 0.05 at week 16) and disease activity (p < 0.05 at both weeks). Accordingly, alanine and aspartate aminotransferase were increased at week 24/25 (p < 0.01). Hepatic expression of inflammatory (Ccl2, Cxcl8) and fibrotic (Pdgf, Serpine1, Col1a1) genes was also increased (p < 0.05). Differences were observed in healthy chow (4% fat, 0% sucrose, 0% cholesterol) fed animals: Envigo animals displayed higher relative liver weights (p < 0.01 at both weeks), liver cholesterol (p < 0.0001 at week 24/25) and aspartate aminotransferase (p < 0.05 at week 16), but lower levels of alkaline phosphatase (p < 0.0001 at week 24/25). These findings accentuates the importance of the breeder and its effect on NASH development and severity. Consequently, this may affect reproducibility, study comparison and limit the potential of developing novel therapies.

scholarly journals Effects of earthworm extract on the lipid profile and fatty liver induced by a high-fat diet in guinea pigs

2021 ◽  
Vol 9 (4) ◽  
pp. 292-292
Author(s):  
Zhenhan Deng ◽  
Shanshan Gao ◽  
Yunfei An ◽  
Yong Huang ◽  
Haifeng Liu ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Guinea Pigs ◽  
High Fat

Anti-Obesity Effects of Chitosan and Psyllium Husk with L-Ascorbic acid in Guinea Pigs

2012 ◽  
Vol 82 (2) ◽  
pp. 113-120 ◽  
Author(s):  
C. Jun ◽  
Y. Jung ◽  
H. Hong ◽  
Park ◽  
H. Kang ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Body Weight ◽  
Weight Gain ◽  
High Fat Diet ◽  
Guinea Pigs ◽  
Body Weight Gain ◽  
Diet Group ◽  
High Fat ◽  
Psyllium Husk ◽  
Fat Excretion

The aim of this study was to investigate whether L-Ascorbic acid would facilitate the anti-obesity effects of chitosan and psyllium husk in vivo. The study was carried out with male Hartley guinea pigs for 5 weeks. The results show that chitosan itself did not influence body weight gain and food efficiency ratio (FER). However, the addition of L-Ascorbic acid to chitosan decreased these parameters; the body weight gain and FER in the chitosan-2 group (high-fat diet group with 5 % chitosan containing 0.5 % L-Ascorbic acid) was significantly (p < 0.05) lower than that in F-controls (high-fat diet group), and was similar to that in controls (normal diet group). L-Ascorbic acid enhanced significantly (p < 0.05) the increases of total fecal weight and fecal fat excretion by chitosan. The addition of L-Ascorbic acid to psyllium husk did not differ from psyllium husk alone in terms of changes in weight gain, plasma lipid levels, and fat pad weight. We found that the addition of L-Ascorbic acid to chitosan influenced the reduction in body weight gain and FER, and the increase in total fecal weight and fecal fat excretion in guinea pigs fed a high-fat diet.

Effect of telmisartan on the therapeutic efficacy of pitavastatin in high-fat diet induced dyslipidemic guinea pigs

2015 ◽  
Vol 762 ◽  
pp. 364-371 ◽  
Author(s):  
Cuihuan Xu ◽  
Dailong Fang ◽  
Xi Chen ◽  
Li Xinyue ◽  
Yu Nie ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Guinea Pigs ◽  
Therapeutic Efficacy ◽  
High Fat

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Topical Application of Capsaicin Reduces Visceral Adipose Fat by Affecting Adipokine Levels in High-Fat Diet-Induced Obese Mice

Obesity ◽  
2012 ◽  
Author(s):  
Gong-Rak Lee ◽  
Mi Kyung Shin ◽  
Dong-Joon Yoon ◽  
Ah-Ram Kim ◽  
Rina Yu ◽  
...  
Keyword(s):  
Topical Application ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Visceral Adipose

POCU1b reverses diabesity induced in rats fed a high-fat diet

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
J Kim ◽  
H Kim ◽  
IH Jeong ◽  
DS Jang ◽  
JS Kim
Keyword(s):  
High Fat Diet ◽  
High Fat
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