Circulating tumor cells in peripheral blood caused by surgical manipulation of non-small-cell lung cancer: pilot study using an immunocytology method

2007 ◽  
Vol 55 (5) ◽  
pp. 189-192 ◽  
Author(s):  
Noriyoshi Sawabata ◽  
Meinoshin Okumura ◽  
Tomoki Utsumi ◽  
Masayoshi Inoue ◽  
Hiroyuki Shiono ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pilot Study ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Peripheral Blood ◽  
Small Cell ◽  
Small Cell Lung ◽  
Surgical Manipulation

scholarly journals Phenotypic characterization of circulating tumor cells in the peripheral blood of patients with small cell lung cancer

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181211 ◽  
Author(s):  
Ippokratis Messaritakis ◽  
Eleni Politaki ◽  
Athanasios Kotsakis ◽  
Eleftheria-Kleio Dermitzaki ◽  
Filippos Koinis ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Peripheral Blood ◽  
Small Cell ◽  
Phenotypic Characterization ◽  
Small Cell Lung

scholarly journals Correlation of circulating tumor cells with myeloid-derived suppressive cells in the peripheral blood of patients with advanced small cell lung cancer

2016 ◽  
Vol 27 ◽  
pp. vi19
Author(s):  
I. Messaritakis ◽  
A. Koutoulaki ◽  
D. Aggouraki ◽  
E.K. Vetsika ◽  
E. Politaki ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Peripheral Blood ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Circulating tumor cells as a prognostic factor in patients with small cell lung cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 7592-7592 ◽  
Author(s):  
Satoshi Igawa ◽  
Jiichiro Sasaki ◽  
Noriyuki Masuda
Keyword(s):  
Lung Cancer ◽  
Prognostic Factor ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Peripheral Blood ◽  
Fluorescent Protein ◽  
Small Cell ◽  
Small Cell Lung

7592 Background: Research on the detection of circulating tumor cells (CTCs) in peripheral blood is currently an important field of research. The aim of this study was to evaluate a new method of detecting CTCs in the peripheral blood of small cell lung cancer (SCLC) patients by using the telomerase-specific replication-selective adenovirus OBP-401. Methods: We prospectively enrolled 30 consecutive newly diagnosed SCLC patients who were being started on chemotherapy or chemoradiotherapy as the subjects of this study. We collected peripheral blood specimens from the SCLC patients and detected viable CTCs in them after incubation with a telomerase-specific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein (GFP) gene. We also investigated whether the CTC count per 7.5 ml of peripheral venous blood was associated with the outcome of SCLC. Results: CTCs were detected in 96% of the patients (29 of the 30 patients). The group of 22 patients with a CTC count of < 2 before treatment (baseline) had a significantly longer median survival time than the group of 8 patients with a CTC count of ≥ 2 before treatment (14.8 months and 3.9 months, respectively, P = 0.001). The results of a multivariate analysis showed that the baseline CTC count was an independent prognostic factor for survival (hazard ratio = 5.11, P = 0.038). Conclusions: CTCs in the peripheral blood of SCLC patients can be detected by the OBP-401assay, and based on the results of this study the CTC count before treatment appears to be a strong prognostic factor.

scholarly journals A Multicenter Pilot Study Examining the Role of Circulating Tumor Cells as a Blood-Based Tumor Marker in Patients with Extensive Small-Cell Lung Cancer

2014 ◽  
Vol 4 ◽  
Author(s):  
Chao H. Huang ◽  
Jo A. Wick ◽  
Gurusingham Sitta Sittampalam ◽  
Victor Sanjit Nirmalanandhan ◽  
Apar Kishor Ganti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pilot Study ◽  
Small Cell Lung Cancer ◽  
Tumor Marker ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung
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