scholarly journals Role of Aspirin in Cancer Prevention

2013 ◽  
Vol 15 (6) ◽  
pp. 533-540 ◽  
Author(s):  
Mangesh A. Thorat ◽  
Jack Cuzick
Keyword(s):  
Cancer Prevention

scholarly journals Mechanisms of Colorectal Cancer Prevention by Aspirin—A Literature Review and Perspective on the Role of COX-Dependent and -Independent Pathways

2020 ◽  
Vol 21 (23) ◽  
pp. 9018
Author(s):  
Ranjini Sankaranarayanan ◽  
D. Ramesh Kumar ◽  
Meric A. Altinoz ◽  
G. Jayarama Bhat
Keyword(s):  
Salicylic Acid ◽  
Cancer Prevention ◽  
Protective Actions ◽  
Direct Exposure ◽  
Anti Cancer ◽  
Chemopreventive Effect ◽  
Colorectal Cancer Prevention ◽  
Preclinical And Clinical Studies ◽  
Shed Light

Aspirin, synthesized and marketed in 1897 by Bayer, is one of the most widely used drugs in the world. It has a well-recognized role in decreasing inflammation, pain and fever, and in the prevention of thrombotic cardiovascular diseases. Its anti-inflammatory and cardio-protective actions have been well studied and occur through inhibition of cyclooxygenases (COX). Interestingly, a vast amount of epidemiological, preclinical and clinical studies have revealed aspirin as a promising chemopreventive agent, particularly against colorectal cancers (CRC); however, the primary mechanism by which it decreases the occurrences of CRC has still not been established. Numerous mechanisms have been proposed for aspirin’s chemopreventive properties among which the inhibition of COX enzymes has been widely discussed. Despite the wide attention COX-inhibition has received as the most probable mechanism of cancer prevention by aspirin, it is clear that aspirin targets many other proteins and pathways, suggesting that these extra-COX targets may also be equally important in preventing CRC. In this review, we discuss the COX-dependent and -independent pathways described in literature for aspirin’s anti-cancer effects and highlight the strengths and limitations of the proposed mechanisms. Additionally, we emphasize the potential role of the metabolites of aspirin and salicylic acid (generated in the gut through microbial biotransformation) in contributing to aspirin’s chemopreventive actions. We suggest that the preferential chemopreventive effect of aspirin against CRC may be related to direct exposure of aspirin/salicylic acid or its metabolites to the colorectal tissues. Future investigations should shed light on the role of aspirin, its metabolites and the role of the gut microbiota in cancer prevention against CRC.

The role of human papillomavirus vaccines in cervical cancer: Prevention and treatment

2018 ◽  
Vol 122 ◽  
pp. 92-97 ◽  
Author(s):  
Giorgio Bogani ◽  
Umberto Leone Roberti Maggiore ◽  
Mauro Signorelli ◽  
Fabio Martinelli ◽  
Antonino Ditto ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cancer Prevention ◽  
Cervical Cancer Prevention ◽  
Papillomavirus Vaccines ◽  
Human Papillomavirus Vaccines ◽  
Prevention And Treatment

scholarly journals Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice

2017 ◽  
Vol 20 (3) ◽  
pp. 425-425
Author(s):  
C.-Z. Wang ◽  
W.-H. Huang ◽  
C.-F. Zhang ◽  
J.-Y. Wan ◽  
Y. Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Prevention ◽  
High Fat Diet ◽  
American Ginseng ◽  
Intestinal Microbiome ◽  
High Fat ◽  
Colon Cancer Prevention

scholarly journals Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

2016 ◽  
Vol 9 ◽  
pp. NMI.S39043 ◽  
Author(s):  
Salma A. Abdelmagid ◽  
Jessica L. MacKinnon ◽  
Sarah M. Janssen ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Future Research ◽  
Pufa Intake ◽  
Diet And Exercise ◽  
Important Study

Diet and exercise are recognized as important lifestyle factors that significantly influence breast cancer risk. In particular, dietary n-3 polyunsaturated fatty acids (PUFAs) have been shown to play an important role in breast cancer prevention. Growing evidence also demonstrates a role for exercise in cancer and chronic disease prevention. However, the potential synergistic effect of n-3 PUFA intake and exercise is yet to be determined. This review explores targets for breast cancer prevention that are common between n-3 PUFA intake and exercise and that may be important study outcomes for future research investigating the combined effect of n-3 PUFA intake and exercise. These lines of evidence highlight potential new avenues for research and strategies for breast cancer prevention.

scholarly journals Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

2016 ◽  
Vol 21 (4) ◽  
pp. 216-226 ◽  
Author(s):  
Bokyung Sung ◽  
Hae Young Chung ◽  
Nam Deuk Kim
Keyword(s):  
Cancer Prevention ◽  
Induction Of Apoptosis

The Role of Vaccines in Cancer Prevention

2001 ◽  
pp. 283-306 ◽  
Author(s):  
Samir N. Khleif ◽  
Helen Frederickson
Keyword(s):  
Cancer Prevention

The Role of Phytochemicals in Cancer Prevention and Cure

2020 ◽  
pp. 127-150
Author(s):  
Braganza Cilwyn ◽  
Soundararajan Vijayarathna ◽  
Shanmugapriya ◽  
Rameshwar Naidu Jegathambigai ◽  
Subramaniam Sreeramanan ◽  
...  
Keyword(s):  
Cancer Prevention ◽  
Prevention And Cure
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