Antidiabetic Potential of Sinigrin Against Streptozotocin-Induced Diabetes via Modulating Inflammation and Oxidative Stress

2021 ◽  
Author(s):  
Jing Zhang ◽  
Shuling Wang
Keyword(s):  
Oxidative Stress ◽  
Streptozotocin Induced Diabetes ◽  
And Oxidative Stress

scholarly journals Effects of silymarin on angiogenesis and oxidative stress in streptozotocin-induced diabetes in mice

2018 ◽  
Vol 108 ◽  
pp. 232-243 ◽  
Author(s):  
Aline Maria Stolf ◽  
Cibele Campos Cardoso ◽  
Helen de Morais ◽  
Carlos Eduardo Alves de Souza ◽  
Luís Alexandre Lomba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes In Mice ◽  
Streptozotocin Induced Diabetes ◽  
And Oxidative Stress

scholarly journals Sodium-Glucose Cotransporter Inhibition Prevents Oxidative Stress in the Kidney of Diabetic Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Horacio Osorio ◽  
Israel Coronel ◽  
Abraham Arellano ◽  
Ursino Pacheco ◽  
Rocío Bautista ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Subcutaneous Administration ◽  
Immunohistochemical Analysis ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Sodium Glucose Cotransporter ◽  
Lower Body Weight ◽  
Sglt2 Inhibition ◽  
Streptozotocin Induced Diabetes ◽  
And Oxidative Stress

The hyperglycemia triggers several chronic diabetic complications mediated by increased oxidative stress that eventually causes diabetic nephropathy. The aim of this study was to examine if the sodium-glucose cotransporter (SGLT2) inhibition prevents the oxidative stress in the kidney of diabetic rats.Methods. The diabetic rat model was established by intraperitoneal injection of streptozotocin (50 mg/kg). The inhibition of SGLT2 was induced by daily subcutaneous administration of phlorizin (0.4 g/kg). Oxidative stress was assessed by catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities and by immunohistochemical analysis of 3-nitrotyrosine (3-NT).Results. Streptozotocin-induced diabetes caused hyperglycemia and lower body weight. The CAT activity decreased in cortex and medulla from diabetic rats; in contrast, the GPx activity increased. Furthermore the 3-NT staining of kidney from diabetic rats increased compared to control rats. The inhibition of SGLT2 decreased hyperglycemia. However, significant diuresis and glucosuria remain in diabetic rats. The phlorizin treatment restores the CAT and GPX activities and decreases 3-NT staining.Conclusion. The inhibition of SGLT2 by phlorizin prevents the hyperglycemia and oxidative stress in kidney of diabetic rats, suggesting a prooxidative mechanism related to SGLT2 activity.

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