Probiotics as a Complementary Therapy in the Model of Cadmium Chloride Toxicity: Crosstalk of β-Catenin, BDNF, and StAR Signaling Pathways

2018 ◽  
Vol 185 (2) ◽  
pp. 404-413 ◽  
Author(s):  
Mai O Kadry ◽  
Rehab Abdel Megeed
Keyword(s):  
Signaling Pathways ◽  
Cadmium Chloride ◽  
Complementary Therapy ◽  
Chloride Toxicity

scholarly journals Dietary silymarin, Silybum marianum extract ameliorates cadmium chloride toxicity in common carp, Cyprinus carpio

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sarmad Ghazi Al-Shawi ◽  
Asraa Yacoob Yousif ◽  
Zena Kadhim Al-Younis ◽  
Rustem Adamovich Shichiyakh ◽  
Angelina Olegovna Zekiy ◽  
...  
Keyword(s):  
Common Carp ◽  
Cyprinus Carpio ◽  
Plasma Levels ◽  
Cadmium Chloride ◽  
Antioxidant Defense ◽  
Protective Effects ◽  
Feeding Period ◽  
Diet Treatment ◽  
Chloride Toxicity ◽  
Total Antioxidant

Abstract The present study evaluated the protective effects of silymarin extract (SIE) on cadmium chloride toxicity in common carp, Cyprinus carpio. Four experimental group were considered for the experiment including: SIE0 (control): non-SIE-supplemented fish, SIE1: fish supplemented with 400 mg SIE/kg diet, SIE2: fish supplemented with1400mg SIE/kg diet, SIE3: fish supplemented with 2400 mg SIE/kg diet). Fish were fed experimental diet for 60 days and then exposed to cadmium chloride (1.5 mg/l or 25% of LC50–96 h) and antioxidant defense components and the survival rate assayed. After 60 days feeding trial, total antioxidant capacity (TAC) levels significantly increased (P<0.01) in 1400–2400 mg SIE/kg diet treatments compared to those in control and 400 mg SIE/kg diet treatment. Malondialdehyde (MDA) (P>0.01) and acetylcholinesterase (AChE) levels (P>0.01) remained unchanged during the feeding period in all treatments. Hepatic catalase (CAT) in all SIE supplemented groups and superoxide dismutase (SOD) and glutathione peroxidase (GPx) in 1400–2400 mg SIE/kg diet treatments significantly elevated (P<0.01) in response to SIE. Plasma levels of hepatic metabolic enzymes [alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatine kinase (CK), lactate dehydrogenase (LDH) ] remained unchanged (P>0.01) in all experimental groups over feeding period. After exposure to cadmium chloride, TAC levels were significantly elevated (P<0.01) in all experimental groups. In control and 400 mg SIE/kg diet treatment, TAC showed lower levels (P<0.01) compared to other groups. MDA levels were significantly increased (P<0.01) in control and fish supplemented with 400 and 1400 mg SIE/kg diet. TAC in the fish of 2400 mg SIE/kg diet treatment remained unchanged (P>0.01), following the exposure. CAT (P<0.01), SOD (P<0.01) and GPx (P<0.01) were significantly elevated in response to cadmium chloride in all groups. However, the treatments, 1400 and 2400 mg SIE/kg diet, showed lower increases (P<0.01) of enzymes. AChE activity (P<0.01) in the liver were significantly decreased in control and fish fed 400 and 1400 mg SIE/kg diet. Exposure to cadmium significantly increased (P<0.01) the plasma levels of ALT, AST, ALP and LDH in control and those fed 400 and 1400 mg SIE/kg diet. The findings of the current study indicated that SIE at a rate of 1400–2400mg/kg diet might enhance antioxidant defense and protect hepatocytes against toxic effects of cadmium.

Hepatoprotective Effects of Solanum nigrum Linn Fruits Against Cadmium Chloride Toxicity in Albino Rats

2014 ◽  
Vol 160 (3) ◽  
pp. 400-408 ◽  
Author(s):  
Emam A. Abdel-Rahim ◽  
Yasmin E. Abdel-Mobdy ◽  
Rhaam F. Ali ◽  
Hend A. Mahmoud
Keyword(s):  
Cadmium Chloride ◽  
Solanum Nigrum ◽  
Albino Rats ◽  
Chloride Toxicity ◽  
Hepatoprotective Effects

scholarly journals CADMIUM TOXICITY INDUCED MORPHOLOGICAL ALTERATION IN INDIGENOUS FISH Heteropneustes fossilis (Bloch.)

2017 ◽  
Vol 3 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Madhulekha Shukla ◽  
Sunita Arya
Keyword(s):  
Acute Toxicity ◽  
Cadmium Chloride ◽  
Room Temperature ◽  
Cadmium Toxicity ◽  
Cadmium Concentration ◽  
Morphological Alteration ◽  
Body Colour ◽  
Heteropneustes Fossilis ◽  
Freshwater Catfish ◽  
Chloride Toxicity

The aim of present study was to determine the toxicity (LC50) of cadmium chloride in freshwater catfish Heteropneustes fossilis. Acute toxicity of cadmium on the indigenous fish H., fossilis was designed in the fish aquarium in laboratory at room temperature in Department of Zoology, DGPG College at Kanpur.Treated fish H., fossilis induced morphological alteration against cadmium chloride toxicity. H. fossilis showed morphological alteration such as increased opercula movement, abnormal swimming, and loss of buoyancy and fading of their body colour. Control fishes were also continuously monitored and compared with the changes caused by cadmium concentration. Heteropneustes fossilis exposed different concentration of cadmium chloride toxicity i.e. 0 ppm for 24 h, 10 ppm for 48h, 15ppm for 72h and 20 ppm for 96 h. From this present study it seems that the indigenous fish, H. fossilis is more susceptible to cadmium toxicity.

Haemato-biochemical changes in experimentally induced cadmium chloride toxicity in Wistar rats

2015 ◽  
Vol 39 (2) ◽  
pp. 179
Author(s):  
M. Angmo ◽  
S. Azmi ◽  
S. Rahman ◽  
A. Ahmad ◽  
M. Sharma ◽  
...  
Keyword(s):  
Cadmium Chloride ◽  
Wistar Rats ◽  
Biochemical Changes ◽  
Chloride Toxicity ◽  
Experimentally Induced

Modulation of cadmium chloride toxicity by sulphur amino acids in hepatoma cells

2006 ◽  
Vol 20 (5) ◽  
pp. 641-648 ◽  
Author(s):  
George Fotakis ◽  
John A. Timbrell
Keyword(s):  
Amino Acids ◽  
Cadmium Chloride ◽  
Hepatoma Cells ◽  
Chloride Toxicity ◽  
Sulphur Amino Acids

scholarly journals Nephroprotective effect of Pleurotus ostreatus extract against cadmium chloride toxicity in rats

2020 ◽  
Vol 92 (1) ◽  
Author(s):  
MOHAMED A. DKHIL ◽  
MARWA S.M. DIAB ◽  
MAHA S. LOKMAN ◽  
HEBA EL-SAYED ◽  
AMIRA A. BAUOMY ◽  
...  
Keyword(s):  
Pleurotus Ostreatus ◽  
Cadmium Chloride ◽  
Chloride Toxicity ◽  
Nephroprotective Effect
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