Ultrasound-guided percutaneous ethanol injection in papillary thyroid cancer metastatic lymph-nodes

Endocrine ◽  
2014 ◽  
Vol 47 (2) ◽  
pp. 648-651 ◽  
Author(s):  
Guia Vannucchi ◽  
Danila Covelli ◽  
Michela Perrino ◽  
Simone De Leo ◽  
Laura Fugazzola
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Papillary Thyroid Cancer ◽  
Percutaneous Ethanol Injection ◽  
Papillary Thyroid ◽  
Ultrasound Guided ◽  
Ethanol Injection ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

scholarly journals Efficacy of Ultrasound-Guided Percutaneous Ethanol Injection Treatment in Patients with a Limited Number of Metastatic Cervical Lymph Nodes from Papillary Thyroid Carcinoma

2011 ◽  
Vol 96 (9) ◽  
pp. 2750-2755 ◽  
Author(s):  
Arne Heilo ◽  
Eva Sigstad ◽  
Kristin Holgersen Fagerlid ◽  
Olav Inge Håskjold ◽  
Krystyna Kotanska Grøholt ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Percutaneous Ethanol Injection ◽  
Papillary Thyroid ◽  
Cervical Lymph Nodes ◽  
Ethanol Injection ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph

Abstract Context: Repeated neck explorations can be a difficult task in patients with recurrent metastatic cervical lymph nodes from papillary thyroid carcinoma (PTC). Objective: The aim of this retrospective study has been to assess the efficacy of ultrasound (US)-guided percutaneous ethanol injection (PEI) as treatment of metastatic cervical lymph nodes from PTC. Materials and Methods: Sixty-nine patients who previously had undergone thyroidectomy for PTC were selected for inclusion. However, three patients were later excluded due to lack of follow-up. Lymph node status was determined by US-guided fine-needle aspiration biopsy and/or by raised levels of thyroglobulin in washouts from the cytological needle. Guided by US, 0.1–1.0 ml of 99.5% ethanol was injected into the metastatic lymph nodes. Results: Three patients (eight metastatic lymph nodes in total) were reassigned to surgery due to progression (multiple new metastases), leaving 63 patients and 109 neck lymph nodes to be included. Mean observation time was 38.4 months (range, 3–72). A total of 101 of the 109 (93%) metastatic lymph nodes responded to PEI treatment, 92 (84%) completely and nine incompletely. Two did not respond, and four progressed. Two lymph nodes previously considered successfully treated showed evidence of malignancy during follow-up. No significant side effects were reported. Conclusion: US-guided PEI treatment of metastatic lymph nodes seems to be an excellent alternative to surgery in patients with a limited number of neck metastases from PTC. This procedure should replace “berry picking” surgery.

scholarly journals Lymphovascular invasion is associated with survival for papillary thyroid cancer

2016 ◽  
Vol 23 (7) ◽  
pp. 555-562 ◽  
Author(s):  
Lauren N Pontius ◽  
Linda M Youngwirth ◽  
Samantha M Thomas ◽  
Randall P Scheri ◽  
Sanziana A Roman ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Papillary Thyroid Cancer ◽  
Lymphovascular Invasion ◽  
Distant Metastases ◽  
Cox Proportional Hazards Model ◽  
Papillary Thyroid ◽  
Metastatic Lymph Nodes ◽  
Cancer Data ◽  
Metastatic Lymph

Data are limited regarding the association between tumor lymphovascular invasion and survival for patients with papillary thyroid cancer (PTC). This study sought to examine lymphovascular invasion as an independent prognostic factor for patients with PTC undergoing thyroid resection. The National Cancer Data Base (2010–2011) was queried for patients with PTC who underwent total thyroidectomy or lobectomy. Patients were classified into two groups based on the presence/absence of lymphovascular invasion. Demographic, clinical and pathological features were evaluated for all patients. A Cox proportional hazards model was utilized to identify factors associated with survival. Results show that 45,415 patients met inclusion criteria; 11.6% had lymphovascular invasion. Patients with lymphovascular invasion were more likely to have larger tumors (2.8cm vs 1.5cm,P<0.01), metastatic lymph nodes (74.1% vs 32.5%,P<0.01), and distant metastases (3.0% vs 0.5%,P<0.01). They were also more likely to receive radioactive iodine (69.3% vs 44.9%,P<0.01). Unadjusted overall 5-year survival was lower for patients who had tumors with lymphovascular invasion (86.6% vs 94.5%) (log-rankP<0.01). After adjustment, increasing patient age (HR=1.06,P<0.01), male gender (HR=1.68,P<0.01), presence of metastatic lymph nodes (HR=1.77,P<0.01), distant metastases (HR=3.49,P<0.01), and lymphovascular invasion (HR=1.88,P<0.01) were associated with compromised survival. For patients with lymphovascular invasion, treatment with RAI was associated with reduced mortality (HR=0.43,P<0.01). The presence of lymphovascular invasion among patients with PTC is independently associated with compromised survival. Patients who have PTC with lymphovascular invasion should be considered higher risk, and adjuvant RAI should be more strongly considered.

Size Distribution of Metastatic Lymph Nodes with Extranodal Extension in Patients with Papillary Thyroid Cancer: A Pilot Study

Thyroid ◽  
2015 ◽  
Vol 25 (2) ◽  
pp. 238-241 ◽  
Author(s):  
Erin H. Alpert ◽  
Bruce M. Wenig ◽  
Eliza H. Dewey ◽  
Henry K. Su ◽  
Laura Dos Reis ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Pilot Study ◽  
Lymph Nodes ◽  
Size Distribution ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Metastatic Lymph Nodes ◽  
Extranodal Extension ◽  
Metastatic Lymph
Sign in / Sign up

Export Citation Format

Share Document