Knockdown of eIF4E suppresses cell growth and migration, enhances chemosensitivity and correlates with increase in Bax/Bcl-2 ratio in triple-negative breast cancer cells

2010 ◽  
Vol 28 (4) ◽  
pp. 1302-1307 ◽  
Author(s):  
Fei-fei Zhou ◽  
Min Yan ◽  
Gui-fang Guo ◽  
Fang Wang ◽  
Hui-juan Qiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals The Potential Prognostic Role of Oligosaccharide-Binding Fold-Containing Protein 2A (OBFC2A) in Triple-Negative Breast Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Qianxue Wu ◽  
Xin Tang ◽  
Wenming Zhu ◽  
Qing Li ◽  
Xiang Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Cancer Cells ◽  
Candidate Genes ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
G1 Phase ◽  
And Migration

BackgroundPatients with triple-negative breast cancer (TNBC) have poor overall survival. The present study aimed to investigate the potential prognostics of TNBC by analyzing breast cancer proteomic and transcriptomic datasets.MethodsCandidate proteins selected from CPTAC (the National Cancer Institute’s Clinical Proteomic Tumor Analysis Consortium) were validated using datasets from METABRIC (Molecular Taxonomy of Breast Cancer International Consortium). Kaplan-Meier analysis and ROC (receiver operating characteristic) curve analysis were performed to explore the prognosis of candidate genes. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis were performed on the suspected candidate genes. Single-cell RNA-seq (scRNA-seq) data from GSE118389 were used to analyze the cell clusters in which OBFC2A (Oligosaccharide-Binding Fold-Containing Protein 2A) was mainly distributed. TIMER (Tumor Immune Estimation Resource) was used to verify the correlation between OBFC2A expression and immune infiltration. Clone formation assays and wound healing assays were used to detect the role of OBFC2A expression on the proliferation, invasion, and migration of breast cancer cells. Flow cytometry was used to analyze the effects of silencing OBFC2A on breast cancer cell cycle and apoptosis.ResultsSix candidate proteins were found to be differentially expressed in non-TNBC and TNBC groups from CPTAC. However, only OBFC2A was identified as an independently poor prognostic gene marker in METABRIC (HR=3.658, 1.881-7.114). And OBFC2A was associated with immune functions in breast cancer. Biological functional experiments showed that OBFC2A might promote the proliferation and migration of breast cancer cells. The inhibition of OBFC2A expression blocked the cell cycle in G1 phase and inhibited the transformation from G1 phase to S phase. Finally, downregulation of OBFC2A also increased the total apoptosis rate of cells.ConclusionOn this basis, OBFC2A may be a potential prognostic biomarker for TNBC.

Arsenic trioxide suppresses cell growth and migration via inhibition of miR-27a in breast cancer cells

2016 ◽  
Vol 469 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Shunhua Zhang ◽  
Cong Ma ◽  
Haijie Pang ◽  
Fanpeng Zeng ◽  
Long Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Arsenic Trioxide ◽  
Breast Cancer Cells ◽  
Cell Growth And Migration ◽  
And Migration

scholarly journals Adenosine Stimulate Proliferation and Migration in Triple Negative Breast Cancer Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0167445 ◽  
Author(s):  
Miriam Fernandez-Gallardo ◽  
Ricardo González-Ramírez ◽  
Alejandro Sandoval ◽  
Ricardo Felix ◽  
Eduardo Monjaraz
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Down-regulation of uPA and uPAR by 3,3′-diindolylmethane contributes to the inhibition of cell growth and migration of breast cancer cells

2009 ◽  
Vol 108 (4) ◽  
pp. 916-925 ◽  
Author(s):  
Aamir Ahmad ◽  
Dejuan Kong ◽  
Zhiwei Wang ◽  
Sanila H. Sarkar ◽  
Sanjeev Banerjee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Down Regulation ◽  
Cell Growth And Migration ◽  
And Migration

Downregulation of GATS gene inhibits proliferation, clonogenicity and migration in triple negative breast cancer cells MDA-MB-231 by cell autophagy

2019 ◽  
Vol 26 (3) ◽  
pp. 261-269
Author(s):  
Fan Feng ◽  
Dongjing Zhang ◽  
Fangkai Han ◽  
Xingtao Zhang ◽  
Tengfei Duan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
And Migration
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