Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer’s Disease

2014 ◽  
Vol 52 (1) ◽  
pp. 514-521 ◽  
Author(s):  
Zimin Xiang ◽  
Meiling Xu ◽  
Mingzhi Liao ◽  
Yongshuai Jiang ◽  
Qinghua Jiang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Association Study ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Genome Wide Association Study ◽  
Purine Metabolism ◽  
Genome Wide Association ◽  
Expression Data ◽  
Genome Wide ◽  
Brain Expression

scholarly journals Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants

PLoS Genetics ◽  
2012 ◽  
Vol 8 (6) ◽  
pp. e1002707 ◽  
Author(s):  
Fanggeng Zou ◽  
High Seng Chai ◽  
Curtis S. Younkin ◽  
Mariet Allen ◽  
Julia Crook ◽  
...  
Keyword(s):  
Association Study ◽  
Human Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Brain Expression

scholarly journals Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns

2019 ◽  
Vol 56 (9) ◽  
pp. 607-616 ◽  
Author(s):  
Eeva Sliz ◽  
Marita Kalaoja ◽  
Ari Ahola-Olli ◽  
Olli Raitakari ◽  
Markus Perola ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecules ◽  
Genetic Factors ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Soluble Adhesion Molecule ◽  
Genome Wide ◽  
Inflammatory Phenotypes

BackgroundInflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood.ObjectiveTo assess genetic determinants of 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) in Finns.MethodsGenome-wide associations of the inflammatory phenotypes were studied in Northern Finland Birth Cohort 1966 (N=5284). A subsequent meta-analysis was completed for 10 phenotypes available in a previous genome-wide association study, adding up to 13 577 individuals in the study. Complementary association tests were performed to study the effect of the ABO blood types on soluble adhesion molecule levels.ResultsWe identified seven novel and six previously reported genetic associations (p<3.1×10−9). Three loci were associated with soluble vascular cell adhesion molecule-1 (sVCAM-1) level, one of which was the ABO locus that has been previously associated with soluble E-selectin (sE-selectin) and intercellular adhesion molecule-1 (sICAM-1) levels. Our findings suggest that the blood type B associates primarily with sVCAM-1 level, while the A1 subtype shows a robust effect on sE-selectin and sICAM-1 levels. The genotypes in the ABO locus associating with higher soluble adhesion molecule levels tend to associate with lower circulating cholesterol levels and lower cardiovascular disease risk.ConclusionThe present results extend the knowledge about genetic factors contributing to the inflammatory load. Our findings suggest that two distinct mechanisms contribute to the soluble adhesion molecule levels in the ABO locus and that elevated soluble adhesion molecule levels per se may not increase risk for cardiovascular disease.

P1-201: Identification of human disease-associated variants in a brain expression genome-wide association study (eGWAS)

2012 ◽  
Vol 8 (4S_Part_5) ◽  
pp. P178-P178
Author(s):  
Nilufer Ertekin-Taner ◽  
Fanggeng Zou ◽  
High Seng Chai ◽  
Curtis Younkin ◽  
Julia Crook ◽  
...  
Keyword(s):  
Association Study ◽  
Human Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Brain Expression

scholarly journals The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes

2012 ◽  
Vol 21 (9) ◽  
pp. 2111-2123 ◽  
Author(s):  
Darren A. Cusanovich ◽  
Christine Billstrand ◽  
Xiang Zhou ◽  
Claudia Chavarria ◽  
Sherryl De Leon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Association Study ◽  
Candidate Genes ◽  
Gene Expression Data ◽  
Lymphocyte Count ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Expression Data ◽  
Genome Wide ◽  
A Genome

Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants (P05.069)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P05.069-P05.069
Author(s):  
N. Taner ◽  
F. Zou ◽  
H. S. Chai ◽  
C. Younkin ◽  
J. Crook ◽  
...  
Keyword(s):  
Association Study ◽  
Human Disease ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Brain Expression
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