Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System

2018 ◽  
Vol 56 (6) ◽  
pp. 4203-4214 ◽  
Author(s):  
Yoichiro Shinohara ◽  
Ayumu Konno ◽  
Keisuke Nitta ◽  
Yasunori Matsuzaki ◽  
Hiroyuki Yasui ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Antibody Production ◽  
Neutralizing Antibody ◽  
Mouse Central Nervous System

scholarly journals CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System

2019 ◽  
Vol 12 ◽  
Author(s):  
Estíbaliz González de San Román ◽  
Iván Manuel ◽  
Catherine Ledent ◽  
Jerold Chun ◽  
Fernando Rodríguez de Fonseca ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mouse Central Nervous System

scholarly journals Apoptotic Cells, Including Macrophages, Are Prominent in Theiler's Virus-Induced Inflammatory, Demyelinating Lesions

2003 ◽  
Vol 77 (7) ◽  
pp. 4383-4388 ◽  
Author(s):  
Brian P. Schlitt ◽  
Matthew Felrice ◽  
Mary Lou Jelachich ◽  
Howard L. Lipton
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Apoptotic Cells ◽  
Theiler's Virus ◽  
Demyelinating Lesions ◽  
Encephalomyelitis Virus ◽  
Mouse Central Nervous System

ABSTRACT Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and ∼17% remained unidentified. In situ hybridization revealed viral RNA in ∼1% of apoptotic cells.

Coxsackievirus Group B Antibodies in the Ventricular Fluid of Infants with Severe Anatomic Defects in the Central Nervous System

PEDIATRICS ◽  
1985 ◽  
Vol 76 (1) ◽  
pp. 64-68
Author(s):  
Charles J. Gauntt ◽  
Richard J. Gudvangen ◽  
Yves W. Brans ◽  
Arthur E. Marlin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Newborn Infants ◽  
Neutralizing Antibody ◽  
Detectable Level ◽  
Immunoglobulin M ◽  
Congenital Infections ◽  
The Central Nervous System ◽  
Group B

Ventricular fluids from four of 28 newborn infants who were initially seen with severe congenital anatomic defects in the central nervous system contained neutralizing antibody to at least one serotype of coxsackieviruses group B. Two of the four infants with anticoxsackieviruses group B antibody in the ventricular fluid did not have a detectable level of the same antibody(ies) in their serum. The ventricular fluid of one of the infants had immunoglobulin M neutralizing antibody directed against coxsackievirus B6. Of 11 mother-infant pairs that had neutralizing antibody to coxsackieviruses group B in both sera, nearly half had antibodies directed against more than one serotype. These data suggest the possibility of an association between congenital infections with coxsackieviruses group B and rare severe CNS defects.

scholarly journals Targeted DNA transfection into the mouse central nervous system using laser-induced stress waves

2005 ◽  
Vol 10 (6) ◽  
pp. 060501 ◽  
Author(s):  
Yasushi Satoh ◽  
Yasunari Kanda ◽  
Mitsuhiro Terakawa ◽  
Minoru Obara ◽  
Katsushige Mizuno ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stress Waves ◽  
Dna Transfection ◽  
Induced Stress ◽  
Mouse Central Nervous System

scholarly journals Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous system

FEBS Letters ◽  
2000 ◽  
Vol 481 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Silvia Rathke-Hartlieb ◽  
Petra Budde ◽  
Stefan Ewert ◽  
Uwe Schlomann ◽  
Martin Sebastian Staege ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Reactive Astrocytes ◽  
Elevated Expression ◽  
Membrane Type ◽  
Mouse Central Nervous System

scholarly journals Floor plate descendants in the ependyma of the adult mouse Central Nervous System

2017 ◽  
Vol 61 (3-4-5) ◽  
pp. 257-265 ◽  
Author(s):  
Sophie Khazanov ◽  
Yael Paz ◽  
Amit Hefetz ◽  
Ben J. Gonzales ◽  
Yaara Netser ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Adult Mouse ◽  
Floor Plate ◽  
Mouse Central Nervous System
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