Vitamin D and Interleukins in Chronic Rhinosinusitis with Polyposis

2022 ◽  
Author(s):  
Prajwal Shrestha ◽  
Rakesh Deepak ◽  
Ashu Seith Bhalla ◽  
Yashdeep Gupta ◽  
Kapil Sikka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis

scholarly journals Relationship of vitamin D3 deficiency and chronic rhinosinusitis with nasal and sinus polyposis in patients referring to the Department of Ear, Nose, and Throat Diseases Department of Vali-asr Hospital in Brigand, Iran

2021 ◽  
pp. 99-104
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Vitamin D3 ◽  
Sinus Surgery ◽  
Control Group ◽  
Case Group ◽  
Significant Difference ◽  
Relationship Of ◽  
Vitamin D3 Deficiency ◽  
Nose And Throat

Introduction: Chronic rhinosinusitis may require referral to an ear, nose, and throat specialist for possible endoscopic sinus surgery if medical management fails. Vitamin D is one of the essential vitamins for the body that is effective in inflammatory processes. Therefore, it seems necessary to confirm the association between the deficiency of this vitamin and the occurrence of chronic rhinosinusitis with nasal polyposis. This study aimed to determine the relationship of vitamin D3 deficiency and chronic rhinosinusitis with nasal and sinus polyposis in patients referring to the Otorhinolaryngology Department of Valiasr Hospital, Birjand, Iran, in 2017. Methods: A case-control study was performed on individuals, including a group of patients with rhinosinusitis and a control group (n=20 each), referring to the Department of Ear, Nose, and Throat Diseases Department of Vali-asr Hospital. Among patients diagnosed with chronic rhinosinusitis, the cases that had polyps on endoscopic examination were included in the study. After completing the consent form, venous blood samples (10cc) were collected from the patients in fasting conditions. The electrochemical luminescence method was used for measuring the level of serum vitamin D. A questionnaire containing demographic information and clinical findings was completed by reviewing the patients' records. Data analysis was performed in SPSS software (Version. 22)using Chi-square and Mann-Whitney U-tests. Results: The mean and median scores of vitamin D level were obtained at14.13±12.99 and 10.25 in the case group, and 18.72±9.29 and 18.77 in the control group, respectively. The level of vitamin D was significantly higher in the control group than in the chronic group (P=0.04). In the case group, 16 (80%) patients lacked vitamin D and 3 patients had an insufficient level of vitamin D. In the control group, 13 (65%) patients lacked vitamin D and 4 cases had an insufficient level of vitamin D. There was no significant difference in vitamin D levels between the two groups (P=0.61). No significant difference was observed between the two clinical symptoms. Conclusion: It was revealed that the lack of vitamin D was likely to be an effective factor in the rhinosinusitis disease; therefore, proceedings need to be taken to cure the deficiency of this vitamin.

Vitamin D pathway regulatory genes encoding 1α-hydroxylase and 24-hydroxylase are dysregulated in sinonasal tissue during chronic rhinosinusitis

2016 ◽  
Vol 7 (2) ◽  
pp. 169-176 ◽  
Author(s):  
Jenna M. Christensen ◽  
Jasmine Cheng ◽  
Peter Earls ◽  
Jenny Gunton ◽  
William Sewell ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Regulatory Genes ◽  
Genes Encoding

scholarly journals Review: Immunology of Sinusitis, Trauma, Asthma, and Sepsis

2015 ◽  
Vol 6 (3) ◽  
pp. ar.2015.6.0140 ◽  
Author(s):  
Marianne Frieri ◽  
Krishan Kumar ◽  
Anthony Boutin
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Vitamin D ◽  
Seasonal Variation ◽  
Organ Failure ◽  
Chronic Rhinosinusitis ◽  
Hereditary Angioedema ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Nf Kappa B

Background This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis, elderly pathogenesis, oxidative stress, depression, seasonal variation, vitamin D, genetic susceptibility and sepsis, hereditary angioedema related to trauma and stress. Objective The objective of this review is to link chronic rhinosinusitis, epidemiology, innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma and sinusitis. Methods A literature search was conducted from several articles, prospective studies, recent reviews and earlier reports. A synergistic relationship develops between activation of the innate immune system and the loss of organ barrier functions. Many complex factors, such as genetics, physical agents, mediators in the development of organ failure both in asthma, sinusitis, stress, depression and trauma, leading to posttraumatic organ failure. Asthma and sepsis, a common condition encountered in hospital environments remains an important cause of death at intensive care units where allergists/immunologists and otolaryngologists are frequently consulted. The patient's immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a proinflammatory mediator release with inappropriate activation. Conclusion This review discussed chronic rhinosinusitis, sinusitis related to trauma, the innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, inflammation, reactive oxygen species, asthma pathogenesis, and asthma in the elderly, oxidative stress, depression, seasonal variation and vitamin D, cytokines, genetic susceptibility related to sepsis, hereditary angioedema related to trauma and stress.

scholarly journals Chronic rhinosinusitis with polyposis and serum vitamin D levels

2019 ◽  
Vol 39 (5) ◽  
pp. 336-340 ◽  
Author(s):  
F. Bavi ◽  
R. Movahed ◽  
M. Salehi ◽  
S. Hossaini ◽  
M. Bakhshaee
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels

scholarly journals Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps

2015 ◽  
Vol 31 (2) ◽  
pp. 63-69 ◽  
Author(s):  
Ling-Feng Wang ◽  
Chen-Yu Chien ◽  
Chih-Feng Tai ◽  
Feng-Yu Chiang ◽  
Jeff Yi-Fu Chen
Keyword(s):  
Vitamin D ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyp ◽  
Nasal Polyps
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