Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells

2022 ◽  
Author(s):  
Yoshitaka Adachi ◽  
Toshiyasu Sakai ◽  
Seitaro Terakura ◽  
Takashi Shiina ◽  
Shingo Suzuki ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Class Ii ◽  
Hla Class Ii

Donor-derived CMV-specific T cells reduce the requirement for CMV-directed pharmacotherapy after allogeneic stem cell transplantation

Blood ◽  
2013 ◽  
Vol 121 (18) ◽  
pp. 3745-3758 ◽  
Author(s):  
Emily Blyth ◽  
Leighton Clancy ◽  
Renee Simms ◽  
Chun K. K. Ma ◽  
Jane Burgess ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Allogeneic Stem Cell Transplantation ◽  
Organ Damage ◽  
Host Disease ◽  
Graft Versus Host ◽  
Key Points

Key Points Infusion of CMV-specific T cells early posttransplant does not increase acute or chronic graft-versus-host disease. CMV-specific T cells early posttransplant reduce the need for pharmacotherapy without increased rates of CMV-related organ damage.

scholarly journals Levels of CMV Specific CD4 T Cells Are Dynamic and Correlate with CMV Viremia after Allogeneic Stem Cell Transplantation

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3634 ◽  
Author(s):  
Thomas Widmann ◽  
Urban Sester ◽  
Barbara C. Gärtner ◽  
Jörg Schubert ◽  
Michael Pfreundschuh ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Cd4 T Cells

scholarly journals B and T Lymphocyte Attenuator Mediates Inhibition of Tumor-Reactive CD8+ T Cells in Patients After Allogeneic Stem Cell Transplantation

2012 ◽  
Vol 189 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Willemijn Hobo ◽  
Wieger J. Norde ◽  
Nicolaas Schaap ◽  
Hanny Fredrix ◽  
Frans Maas ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
T Lymphocyte ◽  
Cd8 T Cells ◽  
Allogeneic Stem Cell Transplantation
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