A Novel Nanoconjugate of Landomycin A with C60 Fullerene for Cancer Targeted Therapy: In Vitro Studies

The transforming growth factor beta (TGF-β) signaling is fundamental for correct embryonic development. However, alterations of this pathway have been correlated with oncogenesis, tumor progression and sustaining of cancer stem cells (CSCs). Cripto-1 (CR-1) and Nodal are two embryonic proteins involved in TGF-β signaling. Their expression is almost undetectable in terminally differentiated cells, but they are often re-expressed in tumor cells, especially in CSCs. Moreover, cancer cells that show high levels of CR-1 and/or Nodal display more aggressive phenotypes in vitro, while in vivo their expression correlates with a worse prognosis in several human cancers. The ability to target CSCs still represents an unmet medical need for the complete eradication of certain types of tumors. Given the prognostic role and the selective expression of CR-1 and Nodal on cancer cells, they represent archetypes for targeted therapy. The aim of this review is to clarify the role of CR-1 and Nodal in cancer stem populations and to summarize the current therapeutic strategy to target CSCs using monoclonal antibodies (mAbs) or other molecular tools to interfere with these two proteins.

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Tumor homing peptide modified liposomes of capecitabine for improved apoptotic activity and HER2 targeted therapy in breast cancer: in vitro studies

RSC Advances ◽

10.1039/c9ra04814f ◽

2019 ◽

Vol 9 (43) ◽

pp. 24987-24994 ◽

Cited By ~ 2

Author(s):

Mantosh Kumar Singh ◽

Sai Kiran S. S. Pindiprolu ◽

Bharat Kumar Reddy Sanapalli ◽

Vidyasrilekha Yele ◽

G. N. K. Ganesh

Keyword(s):

Breast Cancer ◽

Targeted Therapy ◽

Cancer Cells ◽

Breast Cancer Cells ◽

In Vitro Studies ◽

Tumor Homing ◽

Homing Peptide ◽

Apoptotic Activity

Tumor homing peptide modified liposomes loaded with capecitabine (CAP) were prepared in the present study. The in vitro efficacy was tested in breast cancer cells.

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In vitro - studies with antler bone cells: Structure forming capacity, osteocalcin production and influence of sex steroids

Osteologie/Osteology ◽

10.1024/1019-1291.15.4.245 ◽

2006 ◽

Vol 15 (04) ◽

pp. 245-257 ◽

Cited By ~ 3

Author(s):

H. J. Rolf ◽

K. G. Wiese ◽

H. Siggelkow ◽

H. Schliephake ◽

G. A. Bubernik

Keyword(s):

Sex Steroids ◽

Bone Cells ◽

In Vitro Studies ◽

Osteocalcin Production

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Abnormal Sensitivity of Cortisol-Producing Adrenocortical Adenomas to Serotonin: In Vivo and in Vitro Studies

Yearbook of Endocrinology ◽

10.1016/s0084-3741(08)70169-0 ◽

2007 ◽

Vol 2007 ◽

pp. 358-361

Author(s):

D.E. Schteingart

Keyword(s):

In Vitro Studies ◽

Adrenocortical Adenomas

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Selective Glucocorticoid Receptor Agonists for Treatment of Inflammatory Bowel Disease – in vitro studies

Zeitschrift für Gastroenterologie ◽

10.1055/s-0031-1304766 ◽

2011 ◽

Vol 49 (10) ◽

Author(s):

Kerstin Reuter ◽

Stefan Loitsch ◽

Axel Dignass ◽

Jürgen Stein

Keyword(s):

Inflammatory Bowel Disease ◽

Glucocorticoid Receptor ◽

Bowel Disease ◽

In Vitro Studies ◽

Receptor Agonists ◽

Inflammatory Bowel

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Biological and physico-chemical characterization of ultra high diluted Hydrastis canadensis and in vitro studies on mammalian cells

Allgemeine Homöopathische Zeitung ◽

10.1055/s-0037-1601241 ◽

2017 ◽

Vol 262 (02) ◽

pp. 2-76

Author(s):

N Chandrakar ◽

MK Temgire ◽

SG Kane ◽

AK Suresh ◽

J Bellare

Keyword(s):

Mammalian Cells ◽

Chemical Characterization ◽

In Vitro Studies ◽

Hydrastis Canadensis ◽

Physico Chemical

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In Vitro Studies on the Mechanism of the Antifibrino-lytic Action of E-Aminocaproic Acid (EACA)

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651238 ◽

1968 ◽

Vol 19 (03/04) ◽

pp. 584-592 ◽

Cited By ~ 2

Author(s):

Hanna Lukasiewicz ◽

S Niewiarowski

Keyword(s):

Aminocaproic Acid ◽

Test Tube ◽

In Vitro Studies ◽

Lytic Action ◽

Human Plasminogen ◽

Experimental Findings ◽

Fibrin Clots

Summary and Conclusion1. It has been found that EACA does not inhibit activation of human plasminogen into plasmin by SK and UK in a concentration of 5 × 10–2 M. The activation of bovine plasminogen by SK and UK is inhibited by this concentration of EACA but not by a lower one.2. EACA in concentrations of 1,5 × 10–1 – 10–4 M does not inhibit casein proteolysis by plasmin. The proteolysis of fibrinogen and fibrin measured by the release of TCA soluble tyrosine is inhibited by EACA in concentrations of 1,5 × 10–1 – 10–2 M.3. The lysis of non-stabilized clots by plasmin measured in a test tube was inhibited by an EACA concentration of 5 × 10–3 – 5 × 10–4 M. The lysis of stabilized clots by plasmin was inhibited by an EACA concentration of 10–5 M.4. On the basis of experimental findings and data given in literature the authors postulate that the mechanism of the antifibrinolytic effects of EACA consists mainly in a modification of plasmin action on fibrin. These effects are dependent on the structure of the fibrin clots.

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The Venom of the Boomslang (Dispholidus Typus): In Vivo and in Vitro Studies

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653532 ◽

1969 ◽

Vol 21 (02) ◽

pp. 234-244 ◽

Cited By ~ 5

Author(s):

N Mackay ◽

J.C Ferguson ◽

Antonia Bagshawe ◽

A.T.T Forrester ◽

G.P Mcnicol

Keyword(s):

In Vitro Studies

SummaryAn account is given of the effects of boomslang venom in man. Evidence was found of a fibrinolytic state apparently secondary to the coagulant action of the venom. These features rapidly responded to the administration of specific antivenom. In vitro studies, using a homogenate of boomslang parotids, confirmed the coagulant properties of the venom and showed them to be of much greater potency than the proteolytic actions.

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