Synthetic Calibration for Efficient Method Development: Analysis of Tablet API Concentration by Near-Infrared Spectroscopy

2007 ◽  
Vol 2 (3-4) ◽  
pp. 93-105 ◽  
Author(s):  
Robert P. Cogdill ◽  
Thorsten Herkert ◽  
Carl A. Anderson ◽  
James K. Drennen III
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Efficient Method ◽  
Method Development ◽  
Near Infrared ◽  
Development Analysis

scholarly journals Simultaneous Quantification of Paracetamol and Caffeine in Powder Blends for Tableting by NIR-Chemometry

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Dana Maria Muntean ◽  
Cristian Alecu ◽  
Ioan Tomuta
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Method Development ◽  
Near Infrared ◽  
Reference Method ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Drug Content ◽  
Powder Blends

Near-infrared spectroscopy (NIRS) is a technique widely used for rapid and nondestructive analysis of solid samples. A method for simultaneous analysis of the two components of paracetamol and caffeine from powder blends has been developed by using chemometry with near-infrared spectroscopy (NIRS). The method development was performed on samples containing 80, 90, 100, 110, and 120% active pharmaceutical ingredients, and near-infrared spectroscopy (NIRS) spectra of prepared powder blends were recorded and analyzed in order to develop models for the prediction of drug content. Many calibration models were applied in order to perform quantitative determination of drug content in powder, and choosing the appropriate number of factors (principal components) proved to be of highly importance for a PLS chemometric calibration. Once the methods were developed, they were validated in terms of trueness, precision, and accuracy. The results obtained by NIRS methods were compared with those obtained by HPLC reference method, and no significant differences were found. Therefore, the NIR chemometry methods were proved to be a suitable tool for predicting chemical properties of powder blends and for simultaneous determination of active pharmaceutical ingredients.

Method development for the analysis of total bacterial count in raw milk using near-infrared spectroscopy

2016 ◽  
Vol 37 (3) ◽  
pp. e12335 ◽  
Author(s):  
Sonthaya Numthuam ◽  
Jutaporn Hongpathong ◽  
Rangsun Charoensook ◽  
Saowaluk Rungchang
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Method Development ◽  
Near Infrared ◽  
Bacterial Count ◽  
Raw Milk ◽  
Total Bacterial Count

Theoretical and technical advancements of near-infrared spectroscopy and its operational impact in industry

NIR news ◽  
2017 ◽  
Vol 28 (8) ◽  
pp. 17-21 ◽  
Author(s):  
Christian W Huck
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Method Development ◽  
Near Infrared ◽  
Physical Parameters ◽  
Portable Devices ◽  
Chemical Calculation ◽  
Micro Electro Mechanical Systems ◽  
Non Invasive ◽  
Wet Chemical

This article provides a summary of the plenary lecture given at ICNIRS2017 at Copenhagen, Denmark. In principle, near infrared spectroscopy enjoys increasing popularity due to its possibilities for non-invasive, fast, and simultaneous analysis of chemical and physical parameters. Therefore, more frequently in laboratories, time-consuming classical methods including wet-chemical analysis, chromatography, electrophoresis, etc., get substituted by near infrared spectroscopy approaches. On the other hand, hardly any other discipline in analytical chemistry is making such fast technical and theoretical advancements. One of the major challenges is the development of portable devices based on micro-electro mechanical systems or linear variable filters. It belongs to the responsibility of the near infrared spectroscopist to critically evaluate the performance of those with benchtop instruments. For method development, design of experiment and quantum chemical calculation of spectra can give fundamental support. Finally, serious care is to be taken when methods are transferred into the industrial environment.

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