scholarly journals Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury

2008 ◽  
Vol 24 (2) ◽  
pp. 57-65 ◽  
Author(s):  
Jun Wu ◽  
Tian-Sheng Sun ◽  
Ji-Xin Ren ◽  
Xian-Zhang Wang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Transfer ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Viral Vector ◽  
Ex Vivo ◽  
Neurotrophin 3 ◽  
Cord Injury ◽  
Olfactory Ensheathing Glia

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery After Spinal Cord Injury in Adult Rats

2009 ◽  
pp. 110306202455053
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury

Sustained release of neurotrophin-3 via calcium phosphate-coated sutures promotes axonal regeneration after spinal cord injury

2016 ◽  
Vol 94 (7) ◽  
pp. 645-652 ◽  
Author(s):  
Amgad Hanna ◽  
Daniel L. Thompson ◽  
Daniel J. Hellenbrand ◽  
Jae-Sung Lee ◽  
Casey J. Madura ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Calcium Phosphate ◽  
Sustained Release ◽  
Axonal Regeneration ◽  
Neurotrophin 3 ◽  
Cord Injury

PACAP Stimulates Functional Recovery after Spinal Cord Injury through Axonal Regeneration

2014 ◽  
Vol 54 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Masashi Tsuchida ◽  
Tomoya Nakamachi ◽  
Kouichi Sugiyama ◽  
Daisuke Tsuchikawa ◽  
Jun Watanabe ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Cord Injury

Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats

2006 ◽  
Vol 200 (2) ◽  
pp. 392-397 ◽  
Author(s):  
Yutaka Nishio ◽  
Masao Koda ◽  
Keiko Kitajo ◽  
Minoru Seto ◽  
Katsuhiko Hata ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Delayed Treatment ◽  
Rho Kinase Inhibitor ◽  
Cord Injury

scholarly journals Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury

2015 ◽  
Vol 112 (43) ◽  
pp. 13360-13365 ◽  
Author(s):  
Hongmei Duan ◽  
Weihong Ge ◽  
Aifeng Zhang ◽  
Yue Xi ◽  
Zhihua Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Molecular Mechanisms ◽  
Inflammatory Responses ◽  
Cns Injury ◽  
Neurotrophin 3 ◽  
Cord Injury ◽  
Transcriptome Analyses ◽  
Regeneration Capability

Spinal cord injury (SCI) is considered incurable because axonal regeneration in the central nervous system (CNS) is extremely challenging, due to harsh CNS injury environment and weak intrinsic regeneration capability of CNS neurons. We discovered that neurotrophin-3 (NT3)-loaded chitosan provided an excellent microenvironment to facilitate nerve growth, new neurogenesis, and functional recovery of completely transected spinal cord in rats. To acquire mechanistic insight, we conducted a series of comprehensive transcriptome analyses of spinal cord segments at the lesion site, as well as regions immediately rostral and caudal to the lesion, over a period of 90 days after SCI. Using weighted gene coexpression network analysis (WGCNA), we established gene modules/programs corresponding to various pathological events at different times after SCI. These objective measures of gene module expression also revealed that enhanced new neurogenesis and angiogenesis, and reduced inflammatory responses were keys to conferring the effect of NT3-chitosan on regeneration.

scholarly journals Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury

2020 ◽  
Vol 31 (3) ◽  
pp. 623-641.e8 ◽  
Author(s):  
Qi Han ◽  
Yuxiang Xie ◽  
Josue D. Ordaz ◽  
Andrew J. Huh ◽  
Ning Huang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Cord Injury ◽  
Cellular Energetics

ChABC-loaded PLGA nanoparticles: A comprehensive study on biocompatibility, functional recovery, and axonal regeneration in animal model of spinal cord injury

2020 ◽  
Vol 577 ◽  
pp. 119037 ◽  
Author(s):  
Monireh Azizi ◽  
Farhid Farahmandghavi ◽  
Mohammad Taghi Joghataei ◽  
Mojgan Zandi ◽  
Mohammad Imani ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Animal Model ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Plga Nanoparticles ◽  
Cord Injury ◽  
Comprehensive Study

DHAM-BMSC Matrix Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury in Adult Rats

2009 ◽  
Vol 26 (10) ◽  
pp. 1745-1757 ◽  
Author(s):  
Hongsheng Liang ◽  
Peng Liang ◽  
Ye Xu ◽  
Jianing Wu ◽  
Tao Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axonal Regeneration ◽  
Adult Rats ◽  
Cord Injury
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