Mitochondrien unter Stress: Die Rolle der Präsequenzprotease MPP

AbstractThe majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational preprotein import from the cytosol. Proteomic imbalances are sensed and induce cellular stress response pathways to restore proteostasis. Here, the mitochondrial presequence protease MPP serves as example to illustrate the critical role of mitochondrial protein biogenesis and proteostasis on cellular integrity.

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Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders

Biomedicines ◽

10.3390/biomedicines9020099 ◽

2021 ◽

Vol 9 (2) ◽

pp. 99

Author(s):

Shweta Devi ◽

Vijay Kumar ◽

Sandeep Kumar Singh ◽

Ashish Kant Dubey ◽

Jong-Joo Kim

Keyword(s):

Stress Response ◽

Stress Responses ◽

Neurodegenerative Disorders ◽

Cell Damage ◽

Cellular Stress ◽

Clinical Manifestations ◽

Cellular Stress Response ◽

Dramatic Rise ◽

Cellular Stress Responses

Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), are the most concerning disorders due to the lack of effective therapy and dramatic rise in affected cases. Although these disorders have diverse clinical manifestations, they all share a common cellular stress response. These cellular stress responses including neuroinflammation, oxidative stress, proteotoxicity, and endoplasmic reticulum (ER)-stress, which combats with stress conditions. Environmental stress/toxicity weakened the cellular stress response which results in cell damage. Small molecules, such as flavonoids, could reduce cellular stress and have gained much attention in recent years. Evidence has shown the potential use of flavonoids in several ways, such as antioxidants, anti-inflammatory, and anti-apoptotic, yet their mechanism is still elusive. This review provides an insight into the potential role of flavonoids against cellular stress response that prevent the pathogenesis of neurodegenerative disorders.

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Cellular Stress in the Pathogenesis of Muscular Disorders—From Cause to Consequence

International Journal of Molecular Sciences ◽

10.3390/ijms21165830 ◽

2020 ◽

Vol 21 (16) ◽

pp. 5830 ◽

Cited By ~ 1

Author(s):

Alexander Mensch ◽

Stephan Zierz

Keyword(s):

Stress Response ◽

Cellular Stress ◽

Cellular Stress Response ◽

Therapeutic Approaches ◽

Muscular Disorders ◽

Adaptive Mechanisms ◽

Relevant Role ◽

Pathogenetic Factor ◽

Underlying Mechanisms

Cellular stress has been considered a relevant pathogenetic factor in a variety of human diseases. Due to its primary functions by means of contractility, metabolism, and protein synthesis, the muscle cell is faced with continuous changes of cellular homeostasis that require rapid and coordinated adaptive mechanisms. Hence, a prone susceptibility to cellular stress in muscle is immanent. However, studies focusing on the cellular stress response in muscular disorders are limited. While in recent years there have been emerging indications regarding a relevant role of cellular stress in the pathophysiology of several muscular disorders, the underlying mechanisms are to a great extent incompletely understood. This review aimed to summarize the available evidence regarding a deregulation of the cellular stress response in individual muscle diseases. Potential mechanisms, as well as involved pathways are critically discussed, and respective disease models are addressed. Furthermore, relevant therapeutic approaches that aim to abrogate defects of cellular stress response in muscular disorders are outlined.

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Role of the immediate early response 3 (IER3) gene in cellular stress response, inflammation and tumorigenesis

European Journal of Cell Biology ◽

10.1016/j.ejcb.2010.10.002 ◽

2011 ◽

Vol 90 (6-7) ◽

pp. 545-552 ◽

Cited By ~ 75

Author(s):

Alexander Arlt ◽

Heiner Schäfer

Keyword(s):

Stress Response ◽

Cellular Stress ◽

Early Response ◽

Cellular Stress Response ◽

Immediate Early

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On the significance of the role of cellular stress response reactions in the toxic actions of dioxin

Biochemical Pharmacology ◽

10.1016/s0006-2952(03)00157-6 ◽

2003 ◽

Vol 66 (4) ◽

pp. 527-540 ◽

Cited By ~ 59

Author(s):

Fumio Matsumura

Keyword(s):

Stress Response ◽

Cellular Stress ◽

Cellular Stress Response

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Role of the AMP-activated protein kinase in the cellular stress response

Current Biology ◽

10.1016/s0960-9822(00)00070-1 ◽

1994 ◽

Vol 4 (4) ◽

pp. 315-324 ◽

Cited By ~ 291

Author(s):

Julia M. Corton ◽

John G. Gillespie ◽

D.Grahame Hardie

Keyword(s):

Stress Response ◽

Protein Kinase ◽

Cellular Stress ◽

Cellular Stress Response ◽

Amp Activated Protein Kinase

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Role of sorbitol-mediated cellular stress response in obesity-associated retinal degeneration

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2019.108207 ◽

2020 ◽

Vol 679 ◽

pp. 108207 ◽

Cited By ~ 1

Author(s):

Kishore K. Godisela ◽

Singareddy Sreenivasa Reddy ◽

P. Yadagiri Reddy ◽

Ch Uday Kumar ◽

V. Sudhakar Reddy ◽

...

Keyword(s):

Stress Response ◽

Retinal Degeneration ◽

Cellular Stress ◽

Cellular Stress Response

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The Role of PERK in Understanding Development of Neurodegenerative Diseases

International Journal of Molecular Sciences ◽

10.3390/ijms22158146 ◽

2021 ◽

Vol 22 (15) ◽

pp. 8146

Author(s):

Garrett Dalton Smedley ◽

Keenan E. Walker ◽

Shauna H. Yuan

Keyword(s):

Stress Response ◽

Protein Kinase ◽

Neurodegenerative Diseases ◽

Cellular Stress ◽

Cellular Stress Response ◽

Neural Cells ◽

Review Of The Literature ◽

Unfolded Protein ◽

Protein Response

Neurodegenerative diseases are an ever-increasing problem for the rapidly aging population. Despite this, our understanding of how these neurodegenerative diseases develop and progress, is in most cases, rudimentary. Protein kinase RNA (PKR)-like ER kinase (PERK) comprises one of three unfolded protein response pathways in which cells attempt to manage cellular stress. However, because of its role in the cellular stress response and the far-reaching implications of this pathway, error within the PERK pathway has been shown to lead to a variety of pathologies. Genetic and clinical studies show a correlation between failure of the PERK pathway in neural cells and the development of neurodegeneration, but the wide array of methodology of these studies is presenting conflicting narratives about the role of PERK in these affected systems. Because of the connection between PERK and pathology, PERK has become a high value target of study for understanding neurodegenerative diseases and potentially how to treat them. Here, we present a review of the literature indexed in PubMed of the PERK pathway and some of the complexities involved in investigating the protein’s role in the development of neurodegenerative diseases as well as how it may act as a target for therapeutics.

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