Colorectal and gastric metastases from lobular breast cancer that resembled superficial neoplastic lesions

Background: Malignant neoplastic lesions of the breast are one of the main causes of cancer death among women. In tumor cells the expression status of Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers affecting the treatment approach, management and prognosis of breast carcinoma. Objective: To explore the relation of receptor status in recurrent breast cancer to age and time of recurrence. Methods: This study was conducted in National Institute of Cancer Research and Hospital (NICRH) and included 81 female patients between 20 to 75 years with recurrent breast cancer. Detection of receptor status of ER +ve/-ve, PR +ve/-ve, Her-2+ve/-ve was based on the immunohistochemistry staining of tissue samples of malignant neoplastic lesions prepared from tissue biopsies of patients with recurrent breast cancer. All the information were recorded through the pre-structured data collection sheet and analyzed. Results: This study showed that most of the recurrent breast cancer patients were Triple negative breast cancer (TNBC) (39.5%) and among them most of them were younger patients. Younger patients with TNBC had increased risk of recurrence. Most of the recurrence occurred within 1-2 years. Conclusion: It can be concluded that the assessment of the expression of these biornarkers in recurrent tumors provides reliable information for the treatment approach of locoregional tumors. Journal of Surgical Sciences (2018) Vol. 22 (1): 16-20

Download Full-text

89Zr-atezolizumab PET Scan and Lobular Breast Cancer

Case Medical Research ◽

10.31525/ct1-nct04222426 ◽

2020 ◽

Author(s):

Keyword(s):

Breast Cancer ◽

Pet Scan ◽

Lobular Breast Cancer

Download Full-text

Clinical spectrum and pleiotropic nature of CDH1 germline mutations

Journal of Medical Genetics ◽

10.1136/jmedgenet-2018-105807 ◽

2019 ◽

Vol 56 (4) ◽

pp. 199-208 ◽

Cited By ~ 18

Author(s):

Joana Figueiredo ◽

Soraia Melo ◽

Patrícia Carneiro ◽

Ana Margarida Moreira ◽

Maria Sofia Fernandes ◽

...

Keyword(s):

Breast Cancer ◽

Gastric Cancer ◽

Genetic Alterations ◽

Tumour Suppressor Gene ◽

Diffuse Gastric Cancer ◽

Loss Of Function ◽

Lobular Breast Cancer ◽

Cancer Syndrome ◽

Risk Of Cancer ◽

E Cadherin

CDH1 encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour suppressor gene, and it is well established that CDH1 genetic alterations cause diffuse gastric cancer and lobular breast cancer—the foremost manifestations of the hereditary diffuse gastric cancer syndrome. However, in the last decade, evidence has emerged demonstrating that CDH1 mutations can be associated with lobular breast cancer and/or several congenital abnormalities, without any personal or family history of diffuse gastric cancer. To date, no genotype–phenotype correlations have been observed. Remarkably, there are reports of mutations affecting the same nucleotide but inducing distinct clinical outcomes. In this review, we bring together a comprehensive analysis of CDH1-associated disorders and germline alterations found in each trait, providing important insights into the biological mechanisms underlying E-cadherin’s pleiotropic effects. Ultimately, this knowledge will impact genetic counselling and will be relevant to the assessment of risk of cancer development or congenital malformations in CDH1 mutation carriers.

Download Full-text

Extended gene panel testing in lobular breast cancer

Familial Cancer ◽

10.1007/s10689-021-00241-5 ◽

2021 ◽

Author(s):

Elke M. van Veen ◽

D. Gareth Evans ◽

Elaine F. Harkness ◽

Helen J. Byers ◽

Jamie M. Ellingford ◽

...

Keyword(s):

Breast Cancer ◽

Genetic Testing ◽

Detection Rate ◽

Gene Panel ◽

Lobular Breast Cancer ◽

Germline Variants ◽

Panel Testing ◽

Pathogenic Variants ◽

Gene Panel Testing ◽

Increased Risk

AbstractPurpose: Lobular breast cancer (LBC) accounts for ~ 15% of breast cancer. Here, we studied the frequency of pathogenic germline variants (PGVs) in an extended panel of genes in women affected with LBC. Methods: 302 women with LBC and 1567 without breast cancer were tested for BRCA1/2 PGVs. A subset of 134 LBC affected women who tested negative for BRCA1/2 PGVs underwent extended screening, including: ATM, CDH1, CHEK2, NBN, PALB2, PTEN, RAD50, RAD51D, and TP53.Results: 35 PGVs were identified in the group with LBC, of which 22 were in BRCA1/2. Ten actionable PGVs were identified in additional genes (ATM(4), CDH1(1), CHEK2(1), PALB2(2) and TP53(2)). Overall, PGVs in three genes conferred a significant increased risk for LBC. Odds ratios (ORs) were: BRCA1: OR = 13.17 (95%CI 2.83–66.38; P = 0.0017), BRCA2: OR = 10.33 (95%CI 4.58–23.95; P < 0.0001); and ATM: OR = 8.01 (95%CI 2.52–29.92; P = 0.0053). We did not detect an increased risk of LBC for PALB2, CDH1 or CHEK2. Conclusion: The overall PGV detection rate was 11.59%, with similar rates of BRCA1/2 (7.28%) PGVs as for other actionable PGVs (7.46%), indicating a benefit for extended panel genetic testing in LBC. We also report a previously unrecognised association of pathogenic variants in ATM with LBC.

Download Full-text

The Breast in the End: Metastatic Lobular Breast Cancer Found in the Rectum

The American Journal of Gastroenterology ◽

10.14309/00000434-201810001-01544 ◽

2018 ◽

Vol 113 (Supplement) ◽

pp. S888

Author(s):

Mohammed Nayeem ◽

My-Tang Dang ◽

Husain Saleh ◽

Ahmad Abu-Rashed

Keyword(s):

Breast Cancer ◽

Lobular Breast Cancer

Download Full-text

Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer

Breast Cancer Research ◽

10.1186/bcr1785 ◽

2007 ◽

Vol 9 (6) ◽

Cited By ~ 21

Author(s):

Teresa L Mastracci ◽

Fouad I Boulos ◽

Irene L Andrulis ◽

Wan L Lam

Keyword(s):

Breast Cancer ◽

Breast Lesions ◽

Lobular Breast Cancer

Download Full-text

CDH1 germline mutations and hereditary lobular breast cancer

Familial Cancer ◽

10.1007/s10689-016-9869-5 ◽

2016 ◽

Vol 15 (2) ◽

pp. 215-219 ◽

Cited By ~ 41

Author(s):

Giovanni Corso ◽

Mattia Intra ◽

Chiara Trentin ◽

Paolo Veronesi ◽

Viviana Galimberti

Keyword(s):

Breast Cancer ◽

Germline Mutations ◽

Lobular Breast Cancer

Download Full-text

Does a Supplementary Preoperative Breast MRI in Patients with Invasive Lobular Breast Cancer Change Primary and Secondary Surgical Interventions?

Annals of Surgical Oncology ◽

10.1245/s10434-011-1565-y ◽

2011 ◽

Vol 18 (8) ◽

pp. 2143-2149 ◽

Cited By ~ 18

Author(s):

Joerg Heil ◽

Anne Bühler ◽

Michael Golatta ◽

Joachim Rom ◽

Aba Harcos ◽

...

Keyword(s):

Breast Cancer ◽

Breast Mri ◽

Lobular Breast Cancer ◽

Surgical Interventions ◽

Preoperative Breast Mri ◽

Invasive Lobular Breast Cancer

Download Full-text

Cancer as development gone awry: the case for bisphenol-A as a carcinogen

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174411000043 ◽

2011 ◽

Vol 2 (1) ◽

pp. 9-16 ◽

Cited By ~ 4

Author(s):

C. Sonnenschein ◽

P. R. Wadia ◽

B. S. Rubin ◽

A. M. Soto

Keyword(s):

Breast Cancer ◽

Bisphenol A ◽

Developmental Plasticity ◽

Empirical Support ◽

Epidemiological Data ◽

Additional Treatment ◽

Tissue Organization ◽

Estrogen Exposure ◽

Tissue Organization Field Theory ◽

Neoplastic Lesions

The discovery of a rare clear cell carcinoma of the vagina in young women gestationally exposed to the estrogen diethylstilbestrol (DES) lent empirical support to the hypothesis that prenatal exposure to xenoestrogens might cause cancer. This fact contradicted two well-accepted notions: (i) mammalian development was merely the unfolding of a genetic program and (ii) only mutagenic agents could cause cancer. The ecological developmental biology (eco–devo) movement revitalized the concept of developmental plasticity through the occurrence of polyphenisms whereby a single genotype produces diverse phenotypes which are determined by environmental cues. Based on the principles of eco–devo and the tissue organization field theory of carcinogenesis, we hypothesized that developmental exposure to xenoestrogens increased the propensity to develop mammary cancer during adulthood. Bisphenol-A (BPA), a ubiquitous xenoestrogen, was chosen as a model for environmental estrogen exposure. In mice, perinatal exposure to environmentally relevant BPA levels induced alterations of the mammary gland architecture which manifested during fetal morphogenesis and throughout life, including the development of pre-neoplastic lesions. In rats, gestational exposure to BPA induced pre-neoplastic lesions and carcinoma in situ that manifested in adulthood in the absence of any additional treatment. Emerging epidemiological data reveal an increased incidence of breast cancer in women exposed to DES during gestation. Hence, both animal experiments and epidemiological data strengthen the hypothesis that fetal exposure to xenoestrogens may be an underlying cause of the increased incidence of breast cancer observed over the past 50 years.

Download Full-text