scholarly journals Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis

2018 ◽  
Vol 46 (12) ◽  
pp. 4898-4906 ◽  
Author(s):  
Yueying Xie ◽  
Junjie Wang ◽  
Xiaoya Zhao ◽  
Xuli Zhou ◽  
Xiaohui Nie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Cervical Cancer Risk ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

scholarly journals Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

2013 ◽  
Vol 14 (11) ◽  
pp. 6703-6707 ◽  
Author(s):  
Ling-Yan Qin ◽  
Xu Chen ◽  
Ping Li ◽  
Zheng Yang ◽  
Wu-Ning Mo
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Cervical Cancer Risk ◽  
Xrcc3 Thr241met

scholarly journals Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Lin Cheng ◽  
Yan Guo ◽  
Shipeng Zhan ◽  
Peiyuan Xia
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Cervical Cancer Risk ◽  
Leukocyte Antigens ◽  
Knowledge Infrastructure ◽  
Increased Risk ◽  
The Relationship

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significantly associated with an increased risk of cervical cancer in Asia (OR=1.834, 95%CI: 1.107-3.039, Pz=0.019). No significant association was established for the HLA-DP following alleles: DPB1⁎02:01, DPB1⁎02:02, DPB1⁎04:01, DPB1⁎05:01, rs4282438, and rs3077. Conclusion. HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.

scholarly journals Association Between the IL-6 rs1800795 Polymorphism and the Risk of Cervical Cancer: A Meta-Analysis of 1210 Cases and 1525 Controls

2016 ◽  
Vol 16 (5) ◽  
pp. 662-667 ◽  
Author(s):  
Haiping Liu ◽  
Dan Lyu ◽  
Yan Zhang ◽  
Lianbing Sheng ◽  
Ning Tang
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Interleukin 6 ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Developed Countries ◽  
Nucleotide Polymorphisms ◽  
Fixed Effects Model ◽  
Cervical Cancer Risk ◽  
Knowledge Infrastructure

Cervical cancer is the second most common cancer and the third leading cause of cancer-related death among females in less developed countries. Studies have shown that the single-nucleotide polymorphisms of interleukin 6 might be associated with cervical cancer risk. A total of 710 articles from EMBASE, EBSCO, Web of science, PubMed, Springer link, and Chinese National Knowledge Infrastructure databases were reviewed in our study. A meta-analysis on the associations between interleukin 6 rs1800795 polymorphism and cervical cancer risk was carried out by comparison using 5 genetic models. In this systematic review, 5 studies were analyzed. The pooled population included 2735 participants (1210 cases and 1525 controls). The overall odds ratio (G vs C alleles) using fixed-effects model was 0.85 (95% confidence interval 0.75-0.97), P = .02. Our results show that the C genotype of interleukin 6 rs1800795 is associated with higher cervical cancer risk. Our results indicate that interleukin 6 rs1800795 polymorphism might be associated with susceptibility to cervical cancer.

Association between CD95L polymorphism and cervical cancer risk: evidence from a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5137-5142 ◽  
Author(s):  
Jing Zhu ◽  
Lei Lu ◽  
Xiang Cheng ◽  
Rongkai Xie ◽  
Zhengqiong Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Cervical Cancer Risk

Relationship of IL-17A and IL-17F genetic variations to cervical cancer risk: a meta-analysis

2017 ◽  
Vol 11 (5) ◽  
pp. 459-471 ◽  
Author(s):  
Shujuan Yang ◽  
Chaoying Li ◽  
Xuejiao Li ◽  
Xiuling Huang ◽  
Qingge Zhao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Genetic Variations ◽  
Cervical Cancer Risk ◽  
Relationship Of

FAS c.-671A>G polymorphism and cervical cancer risk: a case–control study and meta-analysis

2017 ◽  
Vol 211 ◽  
pp. 18-25 ◽  
Author(s):  
Shing Cheng Tan ◽  
Mohd Pazudin Ismail ◽  
Daniel Roza Duski ◽  
Nor Hayati Othman ◽  
Ravindran Ankathil
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Meta Analysis ◽  
Case Control ◽  
Cervical Cancer Risk ◽  
Control Study

scholarly journals Association between serum copper levels and cervical cancer risk: a meta-analysis

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Min Zhang ◽  
Min Shi ◽  
Yan Zhao
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Case Control ◽  
Serum Copper ◽  
Significant Heterogeneity ◽  
Case Control Studies ◽  
Cervical Cancer Risk

Whether serum copper levels were higher in patients with cervical cancer than that in controls was controversial. Hence, we conducted the present study to explore the relationship between serum copper levels and cervical cancer. We searched PubMed, WanFang, and China National Knowledge Internet (CNKI) for relevant studies before November 30, 2017. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to combine results across studies using the random-effect model. A total of 14 publications involving 747 patients with cervical cancer and 1014 controls were eligible through inclusion criteria. In comparison with controls, serum copper levels were significantly higher in patients with cervical cancer [summary SMD = 1.35; 95%CI: 0.10–2.59], with significant heterogeneity (I2 = 98.8%; P<0.001) was found. Significant association was also found among Asian populations [summary SMD = 1.39; 95%CI: 0.06–2.71]. The association was positive in subgroup analysis of population-based case–control studies (PBCC) [summary SMD = 1.64; 95%CI: 0.02–3.34], but not in hospital-based case–control studies (HBCC). Through a sensitivity analysis, we did not identify any single study to strongly influence the results of our serum copper levels and cervical cancer risk. No publication bias was found in our analysis. In conclusion, our study provided significant evidence of higher serum copper levels in patients with cervical cancer than in controls, suggesting that serum copper exposure was a risk factor on cervical cancer.

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