scholarly journals Effects of two aerobic exercise training protocols on parameters of oxidative stress in the blood and liver of obese rats

2017 ◽  
Vol 68 (5) ◽  
pp. 699-706 ◽  
Author(s):  
Daniela Delwing-de Lima ◽  
Ariene Sampaio Souza Farias Ulbricht ◽  
Carla Werlang-Coelho ◽  
Débora Delwing-Dal Magro ◽  
Victor Hugo Antonio Joaquim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Obese Rats ◽  
Training Protocols

Aerobic exercise training as a mitigator of nonalcoholic fatty liver disease related fibrosis

2015 ◽  
Author(s):  
◽  
Melissa A. Linden
Keyword(s):  
Liver Disease ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Food Restriction ◽  
Cell Activation ◽  
Stellate Cell ◽  
Scar Tissue ◽  
Aerobic Exercise Training ◽  
Nonalcoholic Fatty Liver ◽  
Obese Rats

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Nonalcoholic steatohepatitis (NASH) is a liver disease that is associated with obesity and is characterized by inflammation and fibrosis (scar tissue) within the liver. This condition is difficult to study in humans, therefore rodent models often are used to better understand factors that cause NASH. Additionally, it is unclear if aerobic exercise training can be used to treat the fibrosis that is associated with NASH. In the present study, lean and hyperphagic,obese rats were fed a diet high in fat, sugar and cholesterol to induce NASH. Hyperphagic, obese rats developed more fibrosis and inflammation within the liver than their lean counterparts, suggesting a more advanced disease state. When animals underwent exercise training or food restriction ([about]25% reduction in daily caloric intake)for 12 weeks, the obese rats had modest improvements in both liver fibrosis and inflammation. These improvements were associated with lowered hepatic stellate cell activation, a cell type in the liver that when activated begins to lay down scar tissue. Interestingly, the inactive, obese rat may actually have had the greatest capacity to turn over fibrotic tissue but this was not enough to overcome the diet-induced fibrosis. It is important to note that although both aerobic exercise training and modest food restriction improved liver health, these animals did not have a complete resolution of the liver disease.

Moderate Volume And Intensity Aerobic Exercise Training Does Not Attenuate Postprandial Oxidative Stress In Pre-diabetics

2009 ◽  
Vol 41 ◽  
pp. 1
Author(s):  
Patrick S. Tucker ◽  
Kelsey H. Fisher-Wellman ◽  
Heather K. Bell ◽  
Brian K. Schilling ◽  
Richard J. Bloomer
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Aerobic Exercise Training ◽  
Moderate Volume

Aerobic exercise training improves oxidative stress and ubiquitin proteasome system activity in heart of spontaneously hypertensive rats

2015 ◽  
Vol 402 (1-2) ◽  
pp. 193-202 ◽  
Author(s):  
Luiz Henrique Soares de Andrade ◽  
Wilson Max Almeida Monteiro de Moraes ◽  
Eduardo Hiroshi Matsuo Junior ◽  
Elizabeth de Orleans Carvalho de Moura ◽  
Hanna Karen Moreira Antunes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Spontaneously Hypertensive Rats ◽  
Ubiquitin Proteasome System ◽  
Aerobic Exercise Training ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
System Activity ◽  
Ubiquitin Proteasome

scholarly journals Aerobic exercise training reduces blood pressure, angiotensin II and oxidative stress of patients with resistant hypertension: the EnRiCH trial

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
S Lopes ◽  
J Mesquita-Bastos ◽  
M Teixeira ◽  
D Figueiredo ◽  
J Oliveira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Resistant Hypertension ◽  
Exercise Group ◽  
Aerobic Exercise Training ◽  
Control Group ◽  
Exercise Training Program ◽  
And Oxidative Stress

Abstract Introduction Resistant hypertension is a major challenge of modern cardiovascular medicine, as it is a puzzling problem without a clear solution. Exercise training clearly reduces blood pressure (BP) and oxidative stress in patients with hypertension, however evidence is limited regarding resistant hypertension. Purpose To determine the effect of an aerobic exercise training program in BP, angiotensin II and oxidative stress in patients with resistant hypertension. Methods EnRicH is a prospective, two-center, single-blinded, randomized controlled trial with a parallel two-arm group. Sixty patients with resistant hypertension were randomly assigned in a 1:1 ratio to undergo a 12-week aerobic exercise training program (exercise) or usual care (control). The powered primary efficacy measure was 24-hour ambulatory systolic BP change from baseline. Secondary outcome measures included daytime and nighttime ambulatory BP, office BP, cardiorespiratory fitness, and oxidative stress and inflammatory biomarkers: Interferon-gamma (IFN-y), Angiotensin II, vascular endothelial growth factor (VEGF), and superoxide dismutase (SOD). Results Fifty-three patients (exercise n=26, control n=27) completed the study. Patients were mainly women (54.7%), with an office BP of 140.7±15.9/84.2±9.4 mm Hg and taking an average of 4.6 antihypertensive medications (median, 5; range, 3 to 7). At baseline, no differences were found between groups for the study outcomes and patient characteristics. Ambulatory systolic BP was reduced −7.1 mm Hg (95% CI, −12.8 to −1.4; P=0.015) in the exercise group (127.4±12.2 to 121.2±12.2, p=0.007) compared to control group (126.1±17.2 to 126.9±15.2, p=514) over 24-hour. In addition, 24-hour ambulatory diastolic BP (−5.1 mm Hg, −7.9 to −2.3, P=0.001), daytime ambulatory systolic (−8.4 mm Hg, −14.3 to −2.5, P=0.006), and diastolic BP (−5.7 mm Hg, −9.0 to −2.4, P=0.001) were also reduced in the exercise group compared to the control group. There were no differences in the change of nighttime ambulatory BP between groups. Cardiorespiratory fitness improved in the exercise group by 14% (4.7 ml.kg-1.min-1, P<0.001), while it remained unchanged in the control group (−0.37 ml.kg-1.min-1, P=0.442). A significant between-group difference in favor of exercise group was found for IFN-y (−4.3 pg/mL, 95% CI: −7.1 to −1.5; P=0.003), Angiotensin II (−157.0 pg/mL, 95% CI: −288.1 to −25.9; P=0.020), VEGF (10.53 pg/mL, 95% CI: 0.60 to 22.54; P=0.035), and SOD (0.35 pg/mL, 95% CI: 0.10 to 0.58; P=0.009). Conclusions A 12-week moderate intensity aerobic exercise program reduced ambulatory BP, angiotensin II and oxidative stress in patients with resistant hypertension. The antihypertensive effects of exercise in patients with resistant hypertension may be mediated by positive changes in oxidative stress and inflammatory biomarkers. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): European Union through European Regional Development Fund – Operational Competitiveness Factors Program (COMPETE)Portuguese Government through FCT - Foundation for Science and Technology

scholarly journals Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium

2003 ◽  
Vol 284 (4) ◽  
pp. H1378-H1387 ◽  
Author(s):  
James W. E. Rush ◽  
James R. Turk ◽  
M. Harold Laughlin
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Vascular Function ◽  
Aerobic Exercise Training ◽  
Heme Oxygenase 1 ◽  
Sod Activity ◽  
Aortic Endothelial Cells ◽  
Protein Levels ◽  
Markers Of Oxidative Stress

Vascular oxidative stress contributes to endothelial dysfunction. Aerobic exercise training improves vascular function. The purpose of this study was to test the hypothesis that exercise training would improve the balance of antioxidant to prooxidant enzymes and reduce markers of oxidative stress in aortic endothelial cells (AEC). Female Yucatan miniature pigs either remained sedentary (SED) or were exercise trained (EX) for 16–19 wk. EX pigs had increased AEC SOD-1 protein levels and Cu/Zn SOD activity of the whole aorta compared with SED pigs. Protein levels of other antioxidant enzymes (SOD-2, catalase) were not affected by exercise training. Protein levels of p67phox, a subunit of the prooxidant enzyme NAD(P)H oxidase, were reduced in EX vs. SED AEC. These EX adaptations were associated with lower AEC malondialdehyde levels and decreased phosphorylation of ERK-1/2. Endothelial nitric oxide synthase protein, protein nitrotyrosine content, and heme oxygenase-1 protein were not different in EX vs. SED pigs. We conclude that chronic aerobic exercise training influenced both antioxidant and prooxidant enzymes and decreased indexes of oxidative stress in AEC. These adaptations may contribute to improved endothelial function with exercise training.

scholarly journals Sex Influence on Cardiovascular Autonomic Modulation and on Cardiac and Renal Oxidative Stress: Effects of Aerobic Exercise Training

2020 ◽  
Author(s):  
Guilherme Lemos Shimojo ◽  
Filipe Stoyell-Conti ◽  
Danielle Dias ◽  
Catarina Barboza ◽  
Michelle Sartori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Membrane Lipid ◽  
Aerobic Exercise Training ◽  
Female Rats ◽  
Male Rats ◽  
Stress Profile ◽  
Autonomic Modulation ◽  
Sympathetic Modulation

Abstract The aim of this study was to investigate the difference between sexes after 8 weeks of aerobic exercise training on cardiovascular autonomic modulation and oxidative stress. Wistar rats were distributed into (n = 8/group): sedentary male (SM), trained male (TM), sedentary female (SF) and trained female (TF). Arterial pressure (AP) signals were directly recorded. Cardiovascular autonomic modulation was evaluated by spectral analysis. Aerobic exercise training was performed on treadmill (5 days/wk; 8 wks). Oxidative stress was evaluated on cardiac and renal tissues. Both trained groups presented bradycardia. Exercise training increased heart rate variability (VAR-PI) and decreased cardiac sympathovagal balance in both sexes. Although, no differences observed in AP, the female groups showed a lower vascular sympathetic modulation than the male groups. There was a positive correlation between vascular sympathetic modulation and renal membrane lipid peroxidation (LPO) (r = 0.6, p < 0.01). LPO in cardiac tissue was reduced in the TM, SF and TF groups when compared to the SM group and it was correlated with cardiac sympathetic modulation (r = 0.6, p < 0.01). Only the TF group presented AP variability and renal LPO decreased and cardiac glutathione redox balance (GSH/GSSG) improved when compared to the other groups. Moreover, the trained females showed greater improvement on VAR-PI (~ 1.8 times), on cardiac and renal antioxidant capacity (TRAP: ~2,1 and ~ 1.5 times, respectively), and on cardiac GSSG (~ 2.8 times) than the trained males. In conclusion, female rats showed additional aerobic exercise training induced-cardiovascular autonomic modulation and target organs oxidative stress profile improvement than male rats.

Sign in / Sign up

Export Citation Format

Share Document