Effects of Endocrine Disrupting Agent Bisphenol A on Selected Behavior and Related Gene Expression in Drosophila melanogaster

2021 ◽  
Author(s):  
Morium Begum ◽  
Pallab Paul ◽  
Debasmita Das ◽  
Sujay Ghosh
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Bisphenol A ◽  
Related Gene ◽  
Endocrine Disrupting

scholarly journals Endocrine Disrupting Chemicals, Phthalic Acid and Nonylphenol, Activate Pregnane X Receptor-Mediated Transcription

2000 ◽  
Vol 14 (3) ◽  
pp. 421-428 ◽  
Author(s):  
Hisashi Masuyama ◽  
Yuji Hiramatsu ◽  
Mamoru Kunitomi ◽  
Takafumi Kudo ◽  
Paul N. MacDonald
Keyword(s):  
Gene Expression ◽  
Bisphenol A ◽  
Nuclear Receptor ◽  
Phthalic Acid ◽  
Steroid Hormone ◽  
Endocrine Disrupting Chemicals ◽  
Pregnane X Receptor ◽  
Specific Gene ◽  
Hormone Metabolism ◽  
Endocrine Disrupting

Abstract Recently, Pregnane X receptor (PXR), a new member of the nuclear receptor superfamily, was shown to mediate the effects of several steroid hormones, such as progesterone, glucocorticoid, pregnenolone, and xenobiotics on cytochrome P450 3A genes (CYP3A) through the specific DNA sequence for CYP3A, suggesting that PXR may play a role in steroid hormone metabolism. In this paper, we demonstrated that phthalic acid and nonylphenol, endocrine-disrupting chemicals (EDCs), stimulated PXR-mediated transcription at concentrations comparable to those at which they activate estrogen receptor-mediated transcription using a transient reporter gene expression assay in COS-7 cells. However, bisphenol A, another EDC, had no effect on PXR-mediated transcription, although this chemical significantly enhanced ER-mediated transcription. In the yeast two-hybrid protein interaction assay, PXR interacted with two nuclear receptor coactivator proteins, steroid hormone receptor coactivator-1 and receptor interacting protein 140, in the presence of phthalic acid or nonylphenol. Thus, EDC-occupied PXR may regulate its specific gene expression through the receptor-coactivator interaction. In contrast, these EDCs had no effect on the interaction between PXR and suppressor for gal 1, a component of proteasome. Finally, the expression of CYP3A1 mRNA in the liver of rats exposed to phthalic acid or nonylphenol markedly increased compared with that in rats treated with estradiol, bisphenol A, or ethanol as assessed by competitive RT-PCR. These data suggest that EDCs may affect endocrine functions by altering steroid hormone metabolism through PXR.

scholarly journals Bisphenol A affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster

2022 ◽  
Author(s):  
Chloe Welch ◽  
Eden Johnson ◽  
Angelina Tupikova ◽  
Judith Anderson ◽  
Brendan Tinsley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Cognitive Function ◽  
Bisphenol A

scholarly journals Differential Effects of Acute and Chronic Exercise on Autophagy-related Gene Expression in Drosophila melanogaster

2014 ◽  
Vol 24 (11) ◽  
pp. 1180-1186
Author(s):  
Hee Yeon Kim ◽  
Hye Jin Kim ◽  
Ji Sun Hwang ◽  
Won Jun Lee
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Chronic Exercise ◽  
Related Gene ◽  
Differential Effects

scholarly journals Differential Effects of Acute and Chronic Exercise on Autophagy-Related Gene Expression in Drosophila Melanogaster

2014 ◽  
Vol 46 ◽  
pp. 179
Author(s):  
Hee-Yeon Kim ◽  
Seung-Lyul Oh ◽  
Hye-Jin Kim ◽  
Ji-Sun Hwang ◽  
Bong-Sup Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Chronic Exercise ◽  
Related Gene ◽  
Differential Effects

scholarly journals Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster

2018 ◽  
Vol 19 (1) ◽  
pp. 223 ◽  
Author(s):  
Stefanie Staats ◽  
Anika Wagner ◽  
Bianca Kowalewski ◽  
Florian Rieck ◽  
Sebastian Soukup ◽  
...  
Keyword(s):  
Gene Expression ◽  
Body Composition ◽  
Drosophila Melanogaster ◽  
Stress Response ◽  
Life Span ◽  
Related Gene

scholarly journals Effect of Hawthorn on Drosophila Melanogaster Antioxidant-Related Gene Expression

2014 ◽  
Vol 13 (3) ◽  
pp. 353 ◽  
Author(s):  
Y Zhang ◽  
Ti Shen ◽  
S Liu ◽  
J Zhao ◽  
W Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Related Gene

scholarly journals The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in InRp5545/TM3 Mutant Drosophila melanogaster: A Preliminary Study

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 636 ◽  
Author(s):  
Yuling Dong ◽  
Hao Sun ◽  
Weichao Yang ◽  
Shuang Ma ◽  
Beibei Du ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Gut Microbiota ◽  
Metabolic Diseases ◽  
Insulin Signalling ◽  
Short Chain Fatty Acids ◽  
Preliminary Evidence ◽  
Diet Group ◽  
Standard Diet ◽  
Related Gene

Inulin is considered an efficient prebiotic and is beneficial for metabolic diseases via promoting intestinal probiotic enrichment and the metabolites of short-chain fatty acids (SCFAs). However, the effect of inulin on patients with InR deficiencies has seldom been reported. In this study, the lifespan, related gene expression, and gut microbiota of InRp5545/TM3 (insulin receptor mutant) Drosophila melanogaster under inulin treatment were investigated. The results showed that the lifespan was extended in only males and not in females. Furthermore, distinctly different patterns of gene expression were found between males and females, especially in the insulin/insulin-like growth factor (IGF)-like signalling (IIS) and target of rapamycin (TOR) pathways. Additionally, as a link between inulin and lifespan responses, the gut microbiota was distinctly separated by gender in both the standard diet group and the inulin treatment group, and the relationship between lifespan and the gut microbiota community was stronger in male flies than in females. This study provides preliminary evidence for the gender-dependent lifespan responses to inulin in insulin signalling-deficient Drosophila. However, controls such as wild-type and TM3 flies, and more InR mutant strains with different genetic backgrounds need to be further investigated to elucidate the mechanisms underlying the phenomenon.

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