The Relationship between Sarcopenia and Vitamin D Levels in Adults of Different Ethnicities: Findings from the West China Health and Aging Trend Study

2021 ◽  
Author(s):  
S. Luo ◽  
X. Chen ◽  
L. Hou ◽  
J. Yue ◽  
X. Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
The West ◽  
West China ◽  
Trend Study ◽  
Aging Trend ◽  
Vitamin D Levels ◽  
The Relationship

scholarly journals The Relationship Between Sarcopenia and Vitamin D Levels in Adults of Different Ethnicities: Findings From the West China Health and Aging Trend Study 

2021 ◽  
Author(s):  
Xiaoyan Chen ◽  
Lisha Hou ◽  
Jirong Yue ◽  
Yang Wang ◽  
Xin Xia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Vitamin D ◽  
Ethnic Groups ◽  
Muscle Mass ◽  
Western China ◽  
The West ◽  
West China ◽  
Vitamin D Levels ◽  
The Relationship

Abstract Objective: Sarcopenia is a condition associated with progressive loss of skeletal muscle mass and function resulting in substantial negative health outcomes and disability in older adults. The present study was designed to identify risk factors associated with sarcopenia incidence in various ethnic groups in Western China based upon the Asian Working Group on Sarcopenia 2019 (AWGS2019) criteria in various ethnic groups in Western China and to explore the relationship between sarcopenia and vitamin D levels. Study design: A cross-sectional study of individuals that were 50 years of age or older (n = 4236) from the West China Health and Aging Trend (WCHAT) study. Primary outcome and measures: An InBody 770 instrument was used for bioimpedance-based analyses of muscle mass, while a digital grip strength dynamometer was used for handgrip strength-based measurements of muscle strength. Physical performance was assessed based upon gait speed over 4 m. Other secondary variables were additionally analyzed as potentially relevant risk factors. Results: Sarcopenia affected an estimated 22.45% of studied individuals who were 50 years of age or older, with respective incidence rates in the < 60, 60–64, 65–79, and ≥80 age groups of 11.78%,19.44%, 32.65%, and 67.97%. Rates in males and females were 26.66% and 20.05%, respectively. In males, a significant difference in vitamin D levels was detected when comparing individuals with and without sarcopenia, although no such relationship was detected in females. Following adjustment for confounding variables, binary logistic regression analyses revealed that inadequate vitamin D was able to independently predict sarcopenia risk only in males (OR=1.875,95%CI: 1.109-3.169, P=0.019). Conclusions: Among middle-aged and older adults of multiple ethnicities in western China, we found that inadequate vitamin D was an independent predictor of sarcopenia risk specifically in males.

Association Between Number of Teeth, Denture Use and Frailty: Findings from the West China Health and Aging Trend Study

2020 ◽  
Vol 24 (4) ◽  
pp. 423-428 ◽  
Author(s):  
Y. Zhang ◽  
M. Ge ◽  
W. Zhao ◽  
L. Hou ◽  
X. Xia ◽  
...  
Keyword(s):  
The West ◽  
West China ◽  
Trend Study ◽  
Aging Trend ◽  
Number Of Teeth

Comorbid depressive and anxiety symptoms and frailty among older adults: Findings from the West China health and aging trend study

2020 ◽  
Vol 277 ◽  
pp. 970-976
Author(s):  
Wanyu Zhao ◽  
Yan Zhang ◽  
Xiaolei Liu ◽  
Jirong Yue ◽  
Lisha Hou ◽  
...  
Keyword(s):  
Older Adults ◽  
Anxiety Symptoms ◽  
The West ◽  
West China ◽  
Trend Study ◽  
Aging Trend

The association between systemic inflammatory markers and sarcopenia: Results from the West China Health and Aging Trend Study (WCHAT)

2021 ◽  
Vol 92 ◽  
pp. 104262
Author(s):  
Wan-yu Zhao ◽  
Yan Zhang ◽  
Li-sha Hou ◽  
Xin Xia ◽  
Mei-ling Ge ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
The West ◽  
West China ◽  
Trend Study ◽  
Aging Trend

scholarly journals The relationship between 25(OH) vitamin D levels and COVID-19 onset and disease course in Spanish patients

2021 ◽  
pp. 105928
Author(s):  
Manuel Diaz-Curiel ◽  
Alfonso Cabello ◽  
Rosa Arboiro-Pinel ◽  
Luis Mansur ◽  
Sarah Heili-Frades ◽  
...  
Keyword(s):  
Vitamin D ◽  
Disease Course ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
The Relationship

scholarly journals Relationship Between Level of Serum 25-Hydroxyvitamin D and Risk of Squamous Cell Carcinoma in an Iranian Population

2019 ◽  
pp. 278-282
Author(s):  
Mahboobeh-Sadat Hosseini ◽  
Fereshteh Salarvand ◽  
Amir Houshang Ehsani ◽  
Pedram Noormohammadpour ◽  
Shadi Azizzadeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Outdoor Environment ◽  
Hydroxyvitamin D ◽  
Vitamin D Levels ◽  
History Of ◽  
25 Hydroxyvitamin D ◽  
The Relationship

Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Objective: To investigate the relationship between vitamin D levels and the incidence of skin SCC for the first time in Iran. Methods and Study Design: In this case-control study, 126 subjects were enrolled (63 in each group) out of referents to Razi Skin Hospital in Tehran in 2014. The risk factors for cancer gathered by self-reported questionnaires and blood samples were obtained to measure the level of 25-hydroxyvitamin D. Multivariate logistic regression was used to neutralize the effect of confounding factors. Results: Cases of SCC were more likely to be in men, older than 49 years and working in an outdoor environment, and with longtime exposure to sunlight and a personal history of skin cancers. Family history of skin cancer and of cigarette smoking were not significantly related to SCC. In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. In the adjusted model, vitamin D did not independently predict the likelihood of SCC. Conclusion: Vitamin D level and SCC risk are directly related, although not in an independent fashion. Indeed, this relation is severely confounded by exposure to sunlight, which was evidenced by an increased vitamin D level in the people working outside and the higher prevalence of SCC in the same population.

scholarly journals Causal analysis shows evidence of atopic dermatitis leading to an increase in vitamin D levels

2020 ◽  
Author(s):  
Daniel R Drodge ◽  
Ashley Budu-Aggrey ◽  
Lavinia Paternoster
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Serum Vitamin ◽  
Strong Relationship ◽  
Reverse Direction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Standard Deviations ◽  
The Relationship ◽  
Gwa Studies

AbstractAtopic dermatitis (AD) patients have been observed to have lower vitamin D levels. Previous studies have found little evidence that vitamin D levels causally influence the risk of AD, but the reverse direction has not yet been investigated.Here we used Mendelian Randomization to assess the causal relationship between AD and serum vitamin D levels, using genetic data from the most recent GWA studies of vitamin D and AD.There was little evidence for vitamin D levels causally influencing AD risk (odds per standard deviations increase in log-transformed vitamin D levels =1.233, 95% CI 0.927 to 1.639, P-value =0.150). However, genetic liability for AD raises serum vitamin D levels by 0.043 (95% CI 0.017 to 0.069) standard deviations per doubling of odds of disease (P-value =0.001). The AD-associated filaggrin (FLG) mutation R501X appears to show a particularly strong relationship with vitamin D. However, the relationship between AD and vitamin D holds when R501X is omitted (0.018, 95% CI 0.004 to 0.031, P-value =0.008).We found evidence that AD is causally associated with an increase in serum vitamin D levels. Whilst the AD-associated FLG gene has a particularly strong relationship with vitamin D, other AD SNPs show a consistent direction of effect, suggesting that AD more generally influences serum vitamin D levels.

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