The Effect of Botulinum Toxin on Hair Follicle Cell Regeneration Under Continuous Stress Conditions: a Pilot Animal Study

2022 ◽  
Author(s):  
Bo Hyun Jung ◽  
Sun Hong Song ◽  
Se Jin Yoon ◽  
Jung Hoi Koo ◽  
Ki Yeon Yoo
Keyword(s):  
Botulinum Toxin ◽  
Hair Follicle ◽  
Animal Study ◽  
Follicle Cell ◽  
Stress Conditions ◽  
Cell Regeneration

Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays

2016 ◽  
Vol 30 (6) ◽  
pp. 1016-1020 ◽  
Author(s):  
Li Chen ◽  
Jiaolong Wang ◽  
Glen Mouser ◽  
Yan Chun Li ◽  
Geno Marcovici
Keyword(s):  
Hair Follicle ◽  
Follicle Cell ◽  
Thioctic Acid

scholarly journals Defining Transcriptional Signatures of Human Hair Follicle Cell States

2020 ◽  
Vol 140 (4) ◽  
pp. 764-773.e4 ◽  
Author(s):  
Rie Takahashi ◽  
Adrienne Grzenda ◽  
Thomas F. Allison ◽  
Jeffrey Rawnsley ◽  
Samuel J. Balin ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Follicle Cell ◽  
Human Hair Follicle

3 Vascular endothelial cells: targets for studying the activity of hair follicle cell-produced VEGF

1996 ◽  
Vol 12 (4-6) ◽  
pp. 368-368
Author(s):  
S. Lachgar ◽  
M. Charv�ron ◽  
Y. Gall ◽  
J. Plou�t ◽  
J. L. Bonaf�
Keyword(s):  
Endothelial Cells ◽  
Hair Follicle ◽  
Vascular Endothelial Cells ◽  
Follicle Cell ◽  
Vascular Endothelial

scholarly journals HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition

2020 ◽  
Vol 21 (12) ◽  
pp. 4553
Author(s):  
Sung Min Kim ◽  
Jung-Il Kang ◽  
Hoon-Seok Yoon ◽  
Youn Kyung Choi ◽  
Ji Soo Go ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Hair Growth ◽  
Cell Cycle Progression ◽  
Dermal Papilla ◽  
Follicle Cell ◽  
Hair Shaft ◽  
Promoting Effect ◽  
Dermal Papilla Cells ◽  
Anagen Phase

The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer’s disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells from apoptosis. This study was performed to investigate the promoting effect and action mechanisms of HNG on hair growth. HNG significantly increased DPC proliferation. HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture. In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice. Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs. This means that HNG could induce the anagen phase longer by up-regulating VEGF, which is a Stat3 target gene and one of the anagen maintenance factors. HNG stimulated the anagen phase longer with VEGF up-regulation, and it prevented apoptosis by activating Erk1/2, Akt, and Stat3 signaling.

Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combination

1990 ◽  
Vol 45 (3) ◽  
pp. 168-178 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Peter D. Brown ◽  
William G. Stetler-Stevenson ◽  
Stuart H. Yuspa
Keyword(s):  
Cell Proliferation ◽  
Growth Factors ◽  
Hair Follicle ◽  
Follicle Cell ◽  
Collagenolytic Activity

Modulation of Hair Follicle Cell Proliferation and Collagenolytic Activity by Specific Growth Factorsa

2006 ◽  
Vol 642 (1) ◽  
pp. 281-290 ◽  
Author(s):  
WENDY C. WEINBERG ◽  
PETER D. BROWN ◽  
WILLIAM G. STETLER-STEVENSON ◽  
STUART H. YUSPA
Keyword(s):  
Cell Proliferation ◽  
Hair Follicle ◽  
Specific Growth ◽  
Follicle Cell ◽  
Collagenolytic Activity

scholarly journals Hair Regrowth with Cannabidiol (CBD)-rich Hemp Extract – A Case Series

Cannabis ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 53-59
Author(s):  
Gregory Smith ◽  
John Satino
Keyword(s):  
Hair Follicle ◽  
Synergistic Effects ◽  
Case Series ◽  
Endocannabinoid System ◽  
Follicle Cell ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Vanilloid Receptor ◽  
Follicle Cells ◽  
Better Than

Androgenetic alopecia (AGA) is the most common cause of hair loss. Several FDA approved medications are available but offer limited results. Studies have shown that the endocannabinoid system (ECS) is a key player in hair follicle cell growth. The ECS cannabinoid type one (CB1) receptors are well expressed in the hair follicle cells. Cannabidiol CBD is a negative allosteric modulator of the CB1 receptor and has been shown to result in hair shaft elongation. In addition, the hair follicle cycle phases are controlled by the ECS vanilloid receptor-1 (TRPV1). CBD has also been shown to increase Wnt signaling pathways that are involved in the differentiation of dermal progenitor cells into new hair follicles and maintaining the anagen phase of the hair cycle. The effects of CBD on hair growth are dose dependent and higher doses may result in premature entry into the catagen phase via a receptor known as vanilloid receptor-4 (TRPV4). Topical application of CBD reaches hair follicles where it is a CB1 negative modulator, and TRPV1, and TRPV4 agonist. A study was done of 35 subjects with AGA using a once daily topical hemp oil formulation, averaging about 3-4 mg per day of CBD and minimal amounts of other cannabinoids for six months. A hair count of the greatest area of alopecia was carried out before treatment and again after six months. The results revealed that men did slightly better than women, and the vertex area did better than the temporal areas. On average there was statistically significant 93.5% increase in hair after 6 months. All subjects had some regrowth. There were no reported adverse effects. Since the CBD works through novel mechanisms different from finasteride and minoxidil it can be used in conjunction with these current drugs and would be expected to have synergistic effects.

Culture Techniques and Potential Research Applications of Human Hair Follicle Cells In Vitro

1985 ◽  
Vol 13 (1) ◽  
pp. 8-37
Author(s):  
A.J.M. Vermorken
Keyword(s):  
Epithelial Cells ◽  
Hair Follicle ◽  
Human Hair ◽  
Follicle Cell ◽  
Follicle Cells ◽  
Human Hair Follicle ◽  
Culture Techniques ◽  
Ready Availability ◽  
Skin Biopsies

Since 1980, when human hair follicle cells were cultured in vitro for the first time, a whole series of techniques have been developed that render hair follicle keratinocytes as easy to handle in culture as fibroblasts. As a consequence, one can conclude that the need for a method providing for the routine cultivation of easily obtainable human primary epithelial cells has now been met, and it may be expected that more and more workers will use hair follicle keratinocytes for studies that specifically require human epithelial cells. The ease of culture and the ready availability of material may encourage workers to consider human hair follicle cell culture before either animal models or cultures of cells derived from invasive skin biopsies.

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