scholarly journals Nutritional Status and Nutritional Support Before and After Pancreatectomy for Pancreatic Cancer and Chronic Pancreatitis

2012 ◽  
Vol 3 (4) ◽  
pp. 348-359 ◽  
Author(s):  
Vasiliki Th. Karagianni ◽  
Apostolos E. Papalois ◽  
John K. Triantafillidis
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Nutritional Status ◽  
Nutritional Support ◽  
Before And After

Clinical implication of nutrition for neoadjuvant therapy and impact of nutritional support in pancreatic cancer.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 416-416
Author(s):  
Mitsuru Tashiro ◽  
Suguru Yamada ◽  
Tsutomu Fujii ◽  
Norifumi Hattori ◽  
Hideki Takami ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Nutritional Status ◽  
Neoadjuvant Therapy ◽  
Nutritional Support ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Control Group ◽  
Lymphocyte Ratio ◽  
Rapid Turnover ◽  
Significant Difference

416 Background: Several studies have shown that nutritional support is important to reduce chemotherapy-related toxicities and improve tolerance to chemotherapy, but little is known about the nutritional influence of neoadjuvant therapy (NAT) for pancreatic cancer. The aim of this study was to assess the influence of NAT on nutritional status and the effectiveness of postoperative nutritional support in patients with NAT for pancreatic cancer. Methods: Between 2010 and 2017, 169 consecutive patients who underwent pancreatoduodenectomy of pancreatic cancer were enrolled, and divided into the neoadjuvant group (NAG, n = 70) and the control group (CG, n = 99). We assessed the change of nutritional index (body weight, albumin and rapid turnover proteins; retinol binding protein, prealbumin and transferrin), inflammatory index, and inflammation-based prognostic scores during NAT. Perioperative change of rapid turnover proteins at the point of pre-operation, postoperative day (POD) 5, POD12 and POD21, and perioperative and oncological outcomes between NAG and CG were evaluated. Finally, we divided NAG into nutrition group (n = 27) who received postoperative enteral immunonutrition from POD 1 to POD 21 and without nutrition group (n = 41), and compared perioperative change of rapid turnover proteins between two groups. Results: After NAT, the retinol binding protein, prealbumin, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and prognostic nutrition index significantly got worse in NAG (P < 0.05). The recovery of rapid turnover proteins after POD5 was significantly worse in NAG compared to CG (P < 0.05). There was no significant difference in the incidence of postoperative complications and time to adjuvant therapy between two groups. The recovery of retinol binding protein and prealbumin after POD12 was significantly better in nutrition group compared to without nutrition group (P < 0.05). Conclusions: NAT for pancreatic cancer could decrease nutritional status and its postoperative recovery. Postoperative enteral nutrition could be effective in patients with NAT for pancreatic cancer. Based on these results, we plan to perform the nutritional support at earlier stage of therapy.

scholarly journals Su1452 – Characterization of Nutritional Status Through Phase Angle and Vector Analysis of Bioelectrical Impedance in Patients with Chronic Pancreatitis and Pancreatic Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-556
Author(s):  
Carolina de Luna ◽  
Mariana Gasca Ponce ◽  
Paola Estrada Azarte ◽  
Astrid Ruiz Margáin ◽  
Mario Peláez Luna ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Nutritional Status ◽  
Phase Angle ◽  
Bioelectrical Impedance ◽  
Vector Analysis

scholarly journals Correction of Metabolic Disorders in Patients with Pancreatic Cancer

2020 ◽  
Vol 16 (24) ◽  
pp. 84-90
Author(s):  
K.A. Nikolskaya ◽  
◽  
T.N. Kuzmina ◽  
Ye.A. Dubtsova ◽  
M.A. Kiryukova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Nutritional Status ◽  
Metabolic Disorders ◽  
Clinical Case ◽  
Pancreatic Insufficiency ◽  
Resectable Pancreatic Cancer ◽  
Pancreatogenic Diabetes ◽  
Before And After

Presented the case of complex examination of a patient with pancreatic cancer using a bioimpedance method for assessing the nutritional status before and after surgical treatment. Provided the literature data related to this problem. The presented clinical case demonstrates the features of correction of the nutritional status of a patient with conditionally resectable pancreatic cancer in conditions of cholestasis, severe external pancreatic insufficiency and pancreatogenic diabetes mellitus on the background of constitutional obesity

RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH CHRONIC PANCREATITIS AND THE RISK OF CANCER AFTER SURGICAL TREATMENT

2018 ◽  
Vol 64 (2) ◽  
pp. 228-233
Author(s):  
Vladimir Lubyanskiy ◽  
Vasiliy Seroshtanov ◽  
Ye. Semenova
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Surgical Treatment ◽  
Fibrous Tissue ◽  
Pancreatic Head ◽  
Head Region ◽  
Intestinal Anastomoses ◽  
Resection Of The Pancreas ◽  
Risk Of Cancer

The aim: To analyze results of surgical treatment of patients with chronic pancreatitis (CP) and to assess the causes of pancreatic cancer after surgical treatment. Materials and methods: 137 patients had duodenum-preserving resections of the pancreas. Results: In the histological examination of the pancreas it was established that the growth of fibrous tissue was registered in patients with CP., which in 19 (13.8%) almost completely replaced the acinar tissue. In the long term after the operation from 6 months to 2 years in 8 patients (5.8%) pancreatic cancer was detected. Possible causes of tumor origin were analyzed, the value of preservation of ductal hypertension, which affects the state of the duct’s epithelium, was established. The most commonly used for treatment of chronic pancreatitis the Frey surgery removed pancreatic hypertension but in two patients during the operation an insufficient volume of the pancreatic head was reconstructed. In the case of the abandonment of a large array of fibrous tissue, local hypertension was retained in the region of the ductal structures of the head, which led to the transformation of the duct epithelium. An essential factor in the problem of the preservation of pancreatic hypertension were the stenosis of pancreatic intestinal anastomoses, they arose in the long term in 4 operated patients. With stenosis of anastomosis after duodenum-preserving resection both the hypertension factor and the regeneration factor could be realized, which under certain circumstances might be significant. Conclusion: After resection of the pancreas for CP cancer was diagnosed in 5.8% of patients. The main method of preventing the risk of cancer was performing the Frey surgery for CP eliminating pancreatic hypertension in the head region of the pancreas. Diagnosis of stenosis in the late period after resection of the pancreas was an important element in the prevention of recurrence of cancer since a timely reconstructive operation could improve the drainage of duct structures.

scholarly journals Usefulness of Imaging Response Assessment after Irreversible Electroporation of Localized Pancreatic Cancer—Results from a Prospective Cohort

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2862
Author(s):  
Rasmus V. Flak ◽  
Rune V. Fisker ◽  
Niels H. Bruun ◽  
Mogens T. Stender ◽  
Ole Thorlacius-Ussing ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Irreversible Electroporation ◽  
Response Assessment ◽  
Time Intervals ◽  
Patient Level ◽  
Positron Emission ◽  
Included Patient ◽  
Before And After ◽  
Lesion Level ◽  
Level Analysis

(1) Background: Irreversible electroporation (IRE) is a nonthermal ablation technique that is being studied in nonmetastatic pancreatic cancer (PC). Most published studies use imaging outcomes as an efficacy endpoint, but imaging interpretation can be difficult and has yet to be correlated with survival. The aim of this study was to examine the correlation of imaging endpoints with survival in a cohort of IRE-treated PC patients. (2) Methods: Several imaging endpoints were examined before and after IRE on 18F-fluorodeoxyglucose positron emission tomography (PET) with computed tomography. Separate analyses were performed at the patient and lesion levels. Mortality rate (MR) ratios for imaging endpoints after IRE were estimated. (3) Results: Forty-one patients were included. Patient-level analysis revealed that progressive disease (PD), as defined by RECIST 1.1, is correlated with a higher MR at all time intervals, but PD, as defined by EORTC PET response criteria, is only correlated with the MR in the longest interval. No correlation was found between PD, as defined by RECIST, and the MR in the lesion-level analysis. (4) Conclusions: Patient-level PD, as defined by RECIST, was correlated with poorer survival after IRE ablation, whereas no correlations were observed in the lesion-level analyses. Several promising lesion-level outcomes were identified.

Differences in the Expression of Glutathione S-Transferases in Normal Pancreas, Chronic Pancreatitis, Secondary Chronic Pancreatitis, and Pancreatic Cancer

Pancreas ◽  
2002 ◽  
Vol 24 (3) ◽  
pp. 291-297 ◽  
Author(s):  
Alexis B. Ulrich ◽  
Bruno M. Schmied ◽  
Jens Standop ◽  
Matthias B. Schneider ◽  
Terence A. Lawson ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Normal Pancreas ◽  
Glutathione S Transferases
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