A Comparative, Randomized Control Trial in Patients of Per Vaginal Bleeding Comparing Efficacy of Oral Dydrogesterone Versus Vaginal Progesterone in Successful Pregnancy Outcome for Patients with Recurrent Pregnancy Loss

2021 ◽  
Author(s):  
Ashish Ramchandra Kale ◽  
Ashwini Ashish Kale ◽  
Kanan Yelikar
Keyword(s):  
Pregnancy Outcome ◽  
Randomized Control Trial ◽  
Vaginal Bleeding ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Successful Pregnancy ◽  
Vaginal Progesterone ◽  
Randomized Control

scholarly journals Successful Pregnancy Outcome in a Patient with Antiphospholipid Syndrome : A Case Report

2013 ◽  
Vol 3 (1) ◽  
pp. 44-46
Author(s):  
Hasna Fahmima Haque ◽  
Muhammad Abdur Rahim ◽  
Mohammad Gaffar Amin ◽  
Shahana Zaman ◽  
Pratik Dewan ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Antiphospholipid Syndrome ◽  
Pregnancy Loss ◽  
Low Dose ◽  
Recurrent Pregnancy Loss ◽  
Fetal Loss ◽  
Successful Pregnancy ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
High Index Of Suspicion

Antiphospholipid syndrome (APS) manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss. Diagnosis requires a high index of suspicion during evaluation of women with recurrent pregnancy loss and vascular thrombosis. Low dose aspirin combined with heparin can reduce morbidity and improve the pregnancy outcome. Here we report a case of a 22 year old lady having APS who presented with arthritis, recurrent miscarriages and venous thrombosis. Birdem Med J 2013; 3(1): 44-46 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17126

Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss

2005 ◽  
Vol 94 (11) ◽  
pp. 980-985 ◽  
Author(s):  
Zeev Blumenfeld ◽  
Ronit Leiba ◽  
Naomi Lanir ◽  
Benjamin Brenner ◽  
Galit Sarig
Keyword(s):  
Pregnancy Outcome ◽  
Pregnancy Loss ◽  
Protein S ◽  
Study Groups ◽  
Control Group ◽  
Activity Levels ◽  
Successful Pregnancy ◽  
Free Protein ◽  
Outcome Group ◽  
D Dimer

SummaryRecurrent pregnancy loss (PL) is associated with maternal thrombophilia and prophylaxis with low molecular weight heparin (LMWH) can improve pregnancy outcome in this setting. The aim of this study was to investigate the modulation of systemic hemostatic parameters by enoxaparin in women with recurrent PL and to evaluate plasmatic parameters that would potentially enable monitoring LMWH prophylaxis effect during pregnancy. Study group included 87 women with thrombophilia and PL treated with enoxaparin 40 mg daily vs. 40 mg twice daily. The control group comprised 40 women with normal pregnancies. Blood samples have been collected throughout the period starting at 5-10 weeks of gestation until 6-10 weeks postpartum. The determined plasmatic markers included: anti-Xa activity, total and free tissue factor pathway inhibitor (TFPI), D-dimer, prothrombin fragment 1+2 (PT1+2), activated protein C resistance (APC-SR) and free protein S. Successful pregnancy outcome was recorded in 70 (80.5%) women treated with enoxaparin, with-out correlation to enoxaparin dosage. Seventeen women (19.5%) had pregnancy loss at 16±7 (6-32) weeks of gestation. Anti-Xa levels at 10-15 weeks of gestation were higher (0.39±0.38 u/ml) in the successful pregnancy outcome group compared to the abortion group (0.22±0.2 u/ml). Prophylactic anti-Xa activity levels (0.28±0.13 u/ml) were documented from 15 weeks of gestation until delivery in the successful pregnancy outcome group. Significant increase in anti-Xa, total TFPI and free TFPI levels (P<0.001) was achieved after beginning of LMWH prophylaxis in successful pregnancy outcome group but not in the abortion group. D-dimer and PT1+2 levels appeared to be significantly increased while APC-SR and free protein S levels gradually decreased during pregnancy, with no difference between study groups. These results suggest that LMWH prophylaxis during pregnancy enables modulation of systemic hemostatic parameters via inhibition of factor Xa and increase in plasmatic total and free TFPI levels.

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